Interaction between PLA2R1 and HLA‐DQA1 variants contributes to the increased genetic susceptibility to membranous nephropathy in Western China

Nephrology ◽  
2019 ◽  
Author(s):  
Wei Wang ◽  
Shulei Fan ◽  
Guisen Li ◽  
Amanda Y Wang ◽  
Daqing Hong ◽  
...  
Keyword(s):  
Genetic Susceptibility ◽  
Membranous Nephropathy ◽  
Western China ◽  
Hla Dqa1

scholarly journals The association between variants in PLA2R and HLA-DQA1 and renal outcomes in patients with primary membranous nephropathy in Western China

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Shulei Fan ◽  
Qiuxia Wang ◽  
Amanda Y. Wang ◽  
Ping Zhang ◽  
Xiang Zhong ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Clinical Manifestations ◽  
Human Leukocyte ◽  
Western China ◽  
Renal Outcome ◽  
Nucleotide Polymorphisms ◽  
Renal Outcomes ◽  
Phospholipase A2 Receptor ◽  
Hla Dqa1

Abstract Background Both Genome-wide associations and our previous study have shown that single nucleotide polymorphisms (SNPs) of M-type phospholipase A2 receptor (PLA2R) and human leukocyte antigen complex class II HLA-DQα-chain 1 (HLA-DQA1) gene were identified to be associated with primary membranous nephropathy (PMN). However, whether these SNPs affect clinical manifestation and renal outcome for PMN patients is poorly defined. Here, we evaluated whether there is an association between these SNPs and clinical manifestations and renal outcomes of PMN in a western Chinese cohort. Methods Seven SNPs within PLA2R and one SNP in HLA-DQA1 were selected in our study. Clinical data from 314 patients with PMN were collected and the relationship between the genotype and phenotype was evaluated. A total of 186 patients had follow-up data. We assessed the treatment responses and renal outcomes between patients with these gene polymorphisms after a median follow-up of 18.6 months. Results Eight SNPs were not associated with clinical manifestations of PMN patients (Pc < 0.05). rs3828323 T allele was marginally significantly associated with hypertension (P = 0.008, Pc = 0.064, OR = 1.821). After treatment for PMN, the SR group (including CR and PR) had lower serum creatinine level (68.4 ± 18.8 μmol/L vs. 122.8 ± 126.6 μmol/L, P < 0.001), urea (5.5 ± 1.9 mmol/L vs. 8.0 ± 4.0 mmol/L, P < 0.001), uric acid (358.5 ± 95.1 μmol/L vs. 392.8 ± 118.1 μmol/L, P = 0.037) and urinary protein (0.23 (0.76,1.05) g/d vs. 3.01 (2.06,7.95) g/d, P < 0.001), higher eGFR (100.0 ± 20.1 ml/min/1.73m2 vs. 77.1 ± 35.3 ml/min/1.73m2, P < 0.001) and albumin (41.1 ± 5.1 g/L vs.30.4 ± 8.2 g/L, P < 0.001). We also identified that PMN patients with CT/TT genotype for rs3828323 achieved higher cumulative survival rate than patients with CC genotype. Conclusions Rs3828323 may influence hypertension and renal outcome in patients with PMN. Further research is needed to explore the mechanism for this genotype-disease phenotype association.

scholarly journals The Association Between Variants in PLA2R and HLA-DQA1 and Renal Outcomes in Patients With Primary Membranous Nephropathy in Western China

2020 ◽  
Author(s):  
Shulei Fan ◽  
Qiuxia Wang ◽  
Amanda Y Wang ◽  
Ping Zhang ◽  
Xiang Zhong ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Clinical Manifestations ◽  
Human Leukocyte ◽  
Western China ◽  
Renal Outcome ◽  
Nucleotide Polymorphisms ◽  
Renal Outcomes ◽  
Phospholipase A2 Receptor ◽  
Hla Dqa1

Abstract Background：Both Genome-wide associations and our previous study have shown that single nucleotide polymorphisms (SNPs) of M-type phospholipase A2 receptor (PLA2R) and human leukocyte antigen complex class II HLA-DQα-chain 1 (HLA-DQA1) gene were identified to be associated with primary membranous nephropathy (PMN). However, whether these SNPs affect clinical manifestation and renal outcome for PMN patients is poorly defined. Here, we evaluated whether there is an association between these SNPs and clinical manifestations and renal outcomes of PMN in a western Chinese cohort.Methods: Seven SNPs within PLA2R and one SNP in HLA-DQA1 were selected in our study. Clinical data from 314 patients with PMN were collected and the relationship between the genotype and phenotype was evaluated. A total of 186 patients had follow-up data. We assessed the treatment responses and renal outcomes between patients with these gene polymorphisms after a median follow-up of 18.6 months. Results: Eight SNPs were not associated clinical manifestations of PMN patients (Pc<0.05). rs3828323 T allele was marginally significantly associated with hypertension (P=0.008, Pc=0.064, OR=1.821). After treatment for PMN, urea (OR=1.184, 95%CI:1.030-1.361, P=0.017) was a risk factor for non-remission of the disease, eGFR (OR=0.984, 95%CI:0.970-0.998, P=0.028) and albumin (OR=0.922, 95%CI:0.880-0.966, P=0.001) were protective factors for non-remission of the disease. We also identified that PMN patients with CT/TT genotype for rs3828323 achieved higher cumulative survival rate than patients with CC genotype.Conclusions：Rs3828323 may influence hypertension and renal outcome in patients with PMN. Further research is needed to explore the mechanism for this genotype-disease phenotype association.

scholarly journals Correction to: The association between variants in PLA2R and HLA-DQA1 and renal outcomes in patients with primary membranous nephropathy in Western China

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Shulei Fan ◽  
Qiuxia Wang ◽  
Amanda Y. Wang ◽  
Ping Zhang ◽  
Xiang Zhong ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Western China ◽  
Renal Outcomes ◽  
Hla Dqa1

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals HLA-DQA1 and PLA2R1 Polymorphisms and Risk of Idiopathic Membranous Nephropathy

2013 ◽  
Vol 9 (2) ◽  
pp. 335-343 ◽  
Author(s):  
Gemma Bullich ◽  
José Ballarín ◽  
Artur Oliver ◽  
Nadia Ayasreh ◽  
Irene Silva ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy ◽  
Hla Dqa1

Familial Membranous Nephropathy: An X-Linked Genetic Susceptibility?

2007 ◽  
Vol 108 (1) ◽  
pp. c10-c15 ◽  
Author(s):  
Detlef Bockenhauer ◽  
Hanna Debiec ◽  
Neil Sebire ◽  
Martin Barratt ◽  
Paul Warwicker ◽  
...  
Keyword(s):  
Genetic Susceptibility ◽  
Membranous Nephropathy

scholarly journals Interaction between PLA2R1 and HLA-DQA1 Variants Associates with Anti-PLA2R Antibodies and Membranous Nephropathy

2013 ◽  
Vol 24 (8) ◽  
pp. 1323-1329 ◽  
Author(s):  
Jicheng Lv ◽  
Wanyin Hou ◽  
Xujie Zhou ◽  
Gang Liu ◽  
Fude Zhou ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Hla Dqa1

HLA-DQA1 and -DQB1 Alleles Associated With Genetic Susceptibility to IDDM in a Black Population

Diabetes ◽  
1991 ◽  
Vol 40 (6) ◽  
pp. 748-753 ◽  
Author(s):  
C. H. Mijovic ◽  
D. Jenkins ◽  
K. H. Jacobs ◽  
M. A. Penny ◽  
J. A. Fletcher ◽  
...  
Keyword(s):  
Genetic Susceptibility ◽  
Black Population ◽  
Hla Dqa1

HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han

2004 ◽  
Vol 43 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Xuejun Zhang ◽  
Shengcai Wei ◽  
Sen Yang ◽  
Zaixing Wang ◽  
Anping Zhang ◽  
...  
Keyword(s):  
Genetic Susceptibility ◽  
Psoriasis Vulgaris ◽  
Chinese Han ◽  
Hla Dqa1
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