Sevelamer hydrochloride suppresses proliferation of parathyroid cells during the early phase of chronic renal failure in rats

Nephrology ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 127-133
Author(s):  
Xiao Xiao ◽  
Yan Liu ◽  
Xiaoshi Zhong ◽  
Yun Liu ◽  
Daoyuan Zhou ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Early Phase ◽  
Sevelamer Hydrochloride

scholarly journals Absent 99mTc-MIBI Uptake in the Thyroid Gland during Early Phase of Parathyroid Scintigraphy in Patients with Primary and Secondary Hyperparathyroidism

2018 ◽  
Vol 6 (5) ◽  
pp. 808-813 ◽  
Author(s):  
Anamarija Jovanovska ◽  
Bojana Stoilovska ◽  
Magdalena Mileva ◽  
Daniela Miladinova ◽  
Venjamin Majstorov ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Thyroid Gland ◽  
Thyroid Disease ◽  
Early Phase ◽  
Dual Phase ◽  
Parathyroid Scintigraphy ◽  
Thyroid Uptake ◽  
Planar Images ◽  
99Mtc Mibi

BACKGROUND: Thyroid uptake of technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) during parathyroid scintigraphy can be affected by various conditions.AIM: To evaluate the frequency of absent 99mTc-MIBI uptake by the thyroid gland in the early phase of dual-phase parathyroid scintigraphy.METHODS: The early planar images of dual phase Tc99m MIBI parathyroid scintigraphy from 217 patients performed between 2014 and 2017 were retrospectively analysed. Patients were divided into two groups. The first group included 147 patients with primary hyperparathyroidism and the second group included 70 patients with chronic renal failure. Patient records, laboratory and ultrasonographic data were analysed in all patients. Descriptive statistic was used for data analysis.RESULTS: Out of all patients in the first group, 18 patients (12.24%) showed absent thyroid uptake. Thyroidectomy was performed in 44.4% of these patients, and the rest of them had some thyroid disease. Only one patient had no thyroid or another chronic disease. In the second group, 8 patients (11.42%) presented with absent thyroid uptake of MIBI. Among them, 5 patients had no history of thyroid disease and had been on hemodialysis programme, and 3 patients had hypothyroidism.CONCLUSION: Absent 99mTc-MIBI uptake in the thyroid during the early phase of parathyroid scintigraphy is most frequently related to thyroid disease. A small proportion of patients with chronic renal failure can present with absent 99mTc-MIBI uptake in the thyroid as well. The mechanism for this alteration is still unclear and needs further investigation.

scholarly journals Comparison of Highly Sensitive CRP and Serum Creatinine as an Early Marker of Renal Impairment

1970 ◽  
Vol 7 (1) ◽  
pp. 10-14
Author(s):  
Roksana Yeasmin ◽  
Md Nizamul Hoque Bhuiyan ◽  
Sultana Parveen ◽  
Shamim Ara Ferdous ◽  
Nazmun Nahar
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Early Phase ◽  
Curvilinear Relationship ◽  
Control Group ◽  
Strong Positive Correlation ◽  
Group I ◽  
Hs Crp

A case control study was done during the period of July 2004 to 2005. The study was carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka. 50 diagnosed chronic renal failure patients of both sexes not yet treated by dialysis and 50 age and sex matched healthy subjects were included in the study as case (Group-II) and control (Group-I) respectively. In this study, mean serum HS CRP concentration of CRF patients (50.938 ±38.88)mg/l found to be significantly elevated in comparison to control (1.12±.29mg/l). In CRF patients, serum HS CRP found to show a strong negative correlation with creatinine clearance and a strong positive correlation with blood urea, serum creatinine. This study shows an inverse linear relationship between HS CRP and CCRin contrast to the inverse curvilinear relationship found to exist between serum creatinine and creatinine clearance. Regression analysis between CCR and HS CRP shows a rise of HS CRP Y one unit (mg/l) is accompanied by creatinine clearance to be decreased by 0 .44ml/min. Mean serum HS CRP concentration in chronic renal failure increases significantly. Early phase of decreased CCR can not be detected by the serum creatinine because serum creatinine does not increase until there is significant fall ( 30 ml/min) of creatinine clearance. In contrast to this serum HS CRP begins to rise from the very beginning of the fall of creatinine clearance. So the early phase of decreased creatinine clearance could be detected by simultaneous rise of serum HS CRP. Key Words: HS CRP, CRF, CCR.     DOI = 10.3329/jom.v7i1.1356 J MEDICINE 2006; 7 : 10-14

scholarly journals Contribution to investigation of klinical picture and renal function in patients with endemic nephropathy

2003 ◽  
Vol 131 (1-2) ◽  
pp. 10-16 ◽  
Author(s):  
Danica Bukvic ◽  
Ljubica Djukanovic ◽  
Slavenka Jankovic
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Creatinine Clearance ◽  
Early Phase ◽  
Early Stage ◽  
Number Of Patients ◽  
Endemic Nephropathy ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Up to now, detailed investigation of tubular function in patients with endemic nephropathy have been performed in the relatively small number of patients who have already been in chronic renal failure /3,4,5,9,15/. That is why we started this work with the aim to determine renal function of the patients suffering by endemic nephropathy in different stages of the disease, especially in the early stage of the disease. The study included 119 patients with endemic nephropathy who were grouped according to creatinine clearance values into four groups (Table 1). The first group covered the patients with normal crearinine clearance values, and other three covered the patients who were in the different stages of renal failure. The diagnosis of endemic nephropathy was established according to criteria given by Danilovic /7/ and Velimirovic /8/ after ruling out the known renal diseases. The results of clinical and laboratory examinations were processed by appropriate epidemiological and statistical techniques. The results proved that there was no significant difference between sexes of our patients (p>0,05). Objective examination reveals characteristic tan pale yellow with copperish glow on the cheeks, in 15,48% of our patients in the early stage of the disease, which is in accordance with the results of Velimirovic/8/. Among nephropathy patients 13% of them had kidney smaller than normal measured by sonography, and even 51% measured by static scintigraphy, in the early phase of the disease (Table 4, Table 5). The earlier works /11,12/ mainly supported that kidneys get smaller during renal insufficiency, and in the early phase of the disease kidneys have a normal size, whereas the later works indicated that even the patients with normal glomerular filtration have smaller kidneys/13,14,15,16/. The laboratory findings and urine analysis of this disease suggested absens of biochemical indicators of inflammation in endemic nephropathy patients (Table 2, Table 3), which is in accordance with the previous in investigations. We noticed correlation between ceatinine clearance values and values of serum beta 2 microglobulin (r==,56; p==,0002; Figure 1). It has been documented that with decreased of creatinine clearance values serum values of beta 2 microglobulin increased, in chronic renal failure /22/. Quantitative measuring of proteinuria shows values less than 1,0g/l in all examined patients. Proteinuria of tubular type has been described in endemic nephropathy/5,8,13,16/. Beta 2 microglobulinuria have been registered at 10,97% patients with normal creatinine clearance values (Table 7). Increased urinry contrecation of beta 2 microglobulin is generally accepted as an important feature of endemic nephropathy /19,20,21/. Glicosuria increased with the progression of the disease. Urine osmolallity of endemic nephropathy patients decreased with the progression of chronic renal failure (Table 6). 65,46% of the investigated patients of the first group, who were in the clinically early phase of the disease, had decreased urine osmolallity (measuring by coefficient of osmolallity U osm/Posm). The tubular reabsorbtion of the phosphate decreased with the progression of chronic renal failure and that correlation was statistically significant r<0,69; p<0,05; Figure 2). Fractional tubular excretion of sodium increased with the progression of endemic nephropathy (Table7). The obteined results of the function of proximal tubul are comparabile with the results of the other authors, but in the smaller number of patients /4,13,15,16/. Our results of functional investigations of kidney et patients with endemic nephropathy suggests primary tubular dysfunction, and reduced kidney size and that was registered in the early phase of the disease.

scholarly journals Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats

2003 ◽  
Vol 64 (2) ◽  
pp. 441-450 ◽  
Author(s):  
Kyoko Katsumata ◽  
Kenichiro Kusano ◽  
Michinori Hirata ◽  
Kunihiko Tsunemi ◽  
Nobuo Nagano ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Osteodystrophy ◽  
Ectopic Calcification ◽  
Sevelamer Hydrochloride
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