Cyclic and intermittent very low-protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar fatty (fa/fa ) rats, an animal model of type 2 diabetes and obesity

Nephrology ◽  
2017 ◽  
Vol 22 (12) ◽  
pp. 1030-1034 ◽  
Author(s):  
Munehiro Kitada ◽  
Yoshio Ogura ◽  
Taeko Suzuki ◽  
Itaru Monnno ◽  
Keizo Kanasaki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Animal Model ◽  
Diabetic Nephropathy ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Beneficial Effects ◽  
Low Protein ◽  
Diabetes And Obesity ◽  
Very Low Protein Diet

scholarly journals Very Low Protein Diet for Patients with Chronic Kidney Disease: Recent Insights

2019 ◽  
Vol 8 (5) ◽  
pp. 718 ◽  
Author(s):  
Lucia Di Micco ◽  
Luca Di Lullo ◽  
Antonio Bellasi ◽  
Biagio R. Di Iorio
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Nutritional Therapy ◽  
Sodium Content ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Phosphate Binders ◽  
Beneficial Effects ◽  
Low Protein ◽  
Very Low Protein Diet

Use of nutritional therapy (NT) in chronic kidney disease (CKD) patients is still debated among nephrologists, but it represents a fundamental point in the conservative treatment of CKD. It has been used for years and it has new goals today, such as (1) the reduction of edema, diuretics, and blood pressure values with a low sodium-content diet; (2) the dose reduction of phosphate levels and phosphate binders; (3) the administration of bicarbonate with vegetables in order to correct metabolic acidosis and delay CKD progression; (4) the reduction of the number and the doses of drugs and chemical substances; and (5) the lowering of urea levels, the cure of intestinal microbioma, and the reduction of cyanates levels (such as indoxyl-sulphate and p-cresol sulphate), which are the most recent known advantages achievable with NT. In conclusion, NT and especially very low protein diet (VLPD) have several beneficial effects in CKD patients and slows the progression of CKD.

A Randomized Trial of Low-Protein Diet in Type 1 and in Type 2 Diabetes Mellitus Patients With Incipient and Overt Nephropathy

2005 ◽  
Vol 15 (4) ◽  
pp. 398-406 ◽  
Author(s):  
Bertrand Dussol ◽  
Cecilia Iovanna ◽  
Denis Raccah ◽  
Patrice Darmon ◽  
Sophie Morange ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Randomized Trial ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Overt Nephropathy ◽  
Low Protein

Taurine supplementation restored the changes in pancreatic islet mitochondria in the fetal protein-malnourished rat

2011 ◽  
Vol 106 (8) ◽  
pp. 1198-1206 ◽  
Author(s):  
Yun Yong Lee ◽  
Hwa-Jung Lee ◽  
Seung-Sook Lee ◽  
Jae Soo Koh ◽  
Cheng Ji Jin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pancreatic Islets ◽  
Pancreatic Islet ◽  
Control Diet ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Β Cells ◽  
Taurine Supplementation ◽  
Low Protein

Intra-uterine growth retardation has been linked to the development of type 2 diabetes in later life. Mitochondrial changes have been suggested as a link between fetal malnutrition and adult insulin resistance. Taurine has been implicated in this process. We investigated whether protein malnutrition in early life alters mitochondria of the pancreatic islets in adulthood, and whether taurine supplementation restores these changes. Male offspring of rats fed a control diet, a low-protein diet or a low-protein diet supplemented with taurine during pregnancy and lactation were weaned onto the control diet. In each group, at 20 weeks of age, intravenous glucose tolerance tests, euglycaemic–hyperinsulinaemic clamp studies, morphometric analysis of the pancreatic islets and ultra-structural analysis of the mitochondria of the β-cells were performed. The expressions of cytochrome c oxidase (COX) I and mitochondrial respiratory chain complex II were also measured. Fetal protein-malnourished rats showed decreased pancreatic islet mass and reduced insulin-secretory responses to a glucose load. These rats also showed reduced mitochondrial DNA-encoded COX I gene expression in the islets. Electron microscopic examination showed abnormal mitochondrial shapes in the β-cells of fetal protein-malnourished rats. Taurine supplementation to the low-protein diet restored all these changes. Our findings indicate that a maternal protein-restriction diet causes long-lasting mitochondrial changes that may contribute to the development of type 2 diabetes later in life. The lack of taurine may be a key causative factor for these dysfunctional mitochondrial changes.

scholarly journals Effect of low-protein diet on kidney function in diabetic nephropathy: meta-analysis of randomised controlled trials

BMJ Open ◽  
2013 ◽  
Vol 3 (5) ◽  
pp. e002934 ◽  
Author(s):  
Uru Nezu ◽  
Hiroshi Kamiyama ◽  
Yoshinobu Kondo ◽  
Mio Sakuma ◽  
Takeshi Morimoto ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Kidney Function ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Controlled Trials ◽  
Low Protein ◽  
Randomised Controlled
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