scholarly journals Successful treatment of recurrent Henoch-Schönlein purpura nephritis in a renal allograft with tonsillectomy and steroid pulse therapy

Nephrology ◽  
2016 ◽  
Vol 21 ◽  
pp. 53-56 ◽  
Author(s):  
Takafumi Yamakawa ◽  
Izumi Yamamoto ◽  
Yo Komatsuzaki ◽  
Takahito Niikura ◽  
Yusuke Okabayashi ◽  
...  
2005 ◽  
Vol 44 (6) ◽  
pp. 611-615 ◽  
Author(s):  
Hitoshi SUGIYAMA ◽  
Naomi WATANABE ◽  
Tetsuya ONODA ◽  
Yoko KIKUMOTO ◽  
Miki YAMAMOTO ◽  
...  

1997 ◽  
Vol 9 (3) ◽  
pp. 213-216 ◽  
Author(s):  
Hiromi KATAOKA ◽  
Takashi JOH ◽  
Tadayuki OHSHIMA ◽  
Nobuo TAKAHASHI ◽  
Katsushi WATANABE ◽  
...  

Nephron ◽  
2020 ◽  
pp. 1-5
Author(s):  
Mika Fujimoto ◽  
Kan Katayama ◽  
Kouhei Nishikawa ◽  
Shoko Mizoguchi ◽  
Keiko Oda ◽  
...  

There is no specific treatment for recurrent Henoch-Schönlein purpura nephritis (HSPN) in a transplanted kidney. We herein report a case of a kidney transplant recipient with recurrent HSPN that was successfully treated with steroid pulse therapy and epipharyngeal abrasive therapy (EAT). A 39-year-old Japanese man developed HSPN 4 years ago and had to start hemodialysis after 2 months despite receiving steroid pulse therapy followed by oral prednisolone, plasma exchange therapy, and cyclophosphamide pulse therapy. He had undergone tonsillectomy 3 years earlier in the hopes of achieving a better outcome of a planned kidney transplantation and received a living-donor kidney transplantation from his mother 1 year earlier. Although there were no abnormalities in the renal function or urinalysis 2 months after transplantation, a routine kidney allograft biopsy revealed evidence of mesangial proliferation and cellular crescent formation. Mesangial deposition for IgA and C3 was noted, and he was diagnosed with recurrent HSPN histologically. Since the renal function and urinalysis findings deteriorated 5 months after transplantation, 2 courses of steroid pulse therapy were performed but were ineffective. EAT using 0.5% zinc chloride solution once per day was combined with the third course of steroid pulse therapy, as there were signs of chronic epipharyngitis. His renal function recovered 3 months after daily EAT and has been stable for 1.5 years since transplantation. Daily EAT continued for >3 months might be a suitable strategy for treating recurrent HSPN in cases of kidney transplantation.


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