Manifestation of tranexamic acid toxicity in chronic kidney disease and kidney transplant patients: A report of four cases and review of literature

Nephrology ◽  
2017 ◽  
Vol 22 (4) ◽  
pp. 316-321 ◽  
Author(s):  
Terry King-Wing Ma ◽  
Kai Ming Chow ◽  
Bonnie Ching-Ha Kwan ◽  
Chi Bon Leung ◽  
Cheuk Chun Szeto ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Tranexamic Acid ◽  
Kidney Transplant ◽  
Review Of Literature ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Acid Toxicity

scholarly journals Reduction of functional cardiovascular reserve in the stages of chronic kidney disease

2020 ◽  
Vol 66 (4) ◽  
pp. 437-444
Author(s):  
Juliana Schneider ◽  
Paula Caitano Fontela ◽  
Matias Nunes Frizzo ◽  
Ligia Beatriz Bento Franz ◽  
Olvânia Basso de Oliveira ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Transplant ◽  
Sedentary Lifestyle ◽  
Peak Exercise ◽  
P Value ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Circulatory Power ◽  
Oxygen Uptake Efficiency Slope

SUMMARY OBJECTIVE Patients with chronic kidney disease (CKD) present reduced oxygen consumption at peak exercise (VO2 peak). No studies have evaluated objective measures of the cardiovascular reserve, besides VO2 peak and VO2 at the anaerobic threshold (VO2 AT), and compared these measures among ckd patients at different stages of the disease. METHODS Fifty-eight patients [pre-dialysis group (PD)=26, hemodialysis group (HD)=20, and post-kidney transplant group (KT)=12] were included. The following measures of cardiovascular reserve were obtained: 1) peak heart rate (HR); 2) peak systolic blood pressure (SBP); 3) VO2 peak and % predicted; 4) VO2 AT and % of predicted VO2; 5) peak circulatory power; 6) ventilatory efficiency for the production of carbon dioxide (VE/VCO2 slope); 7) oxygen uptake efficiency slope (OUES); and 8) recovery of gas exchange. RESULTS The VO2 peak and VO2 AT in the PD, HD, and KT groups were reduced to 86% and 69%, 70% and 57%, and 79% and 64% of the predicted value, respectively. Patients in the HD group had lower VO2 peak (17.5±5.9 vs. 23.2±8.2 [p-value=0.036]) and VO2 AT (14.0±5.2 vs. 18.3±4.7 [p-value=0.039]) compared to patients in the KT group. OUES was significantly lower in the HD group compared to the KT group (p-value=0.034). Age in the PD, HD, and KT groups and sedentary lifestyle in the KT group were predictors of VO2 peak. CONCLUSIONS CKD patients presented a reduction in cardiovascular reserve regardless of the stage of the disease. However, hemodialysis patients presented a greater reduction of cardiovascular reserve when compared to post-kidney transplant patients.

Furosemide test in stage III-chronic kidney disease and kidney transplant patients on tacrolimus

2012 ◽  
Vol 45 (5) ◽  
pp. 1471-1474 ◽  
Author(s):  
Carlos G. Musso ◽  
Matilde Navarro ◽  
Cesar Mombelli ◽  
Cora Giordani ◽  
Roxana Groppa ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Transplant ◽  
Stage Iii ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Furosemide Test

scholarly journals FP343HEALTHCARE COSTS OF CHRONIC KIDNEY DISEASE, DIALYSIS AND KIDNEY TRANSPLANT PATIENTS COMPARED TO MATCHED CONTROLS

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i147-i147 ◽  
Author(s):  
Manon van Oosten ◽  
Kitty Jager ◽  
Susan Logtenberg ◽  
Martijn Leegte ◽  
Marc Hemmelder ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Quality of life and spirituality of patients with chronic kidney disease: pre- and post-transplant analysis

2020 ◽  
Vol 73 (suppl 5) ◽  
Author(s):  
Letícia Meazzini de Olivera ◽  
Meiry Fernanda Pinto Okuno ◽  
Dulce Aparecida Barbosa ◽  
Ricardo de Castro Cintra Sesso ◽  
Gerson Scherrer Júnior ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Peritoneal Dialysis ◽  
Kidney Disease ◽  
Kidney Transplant ◽  
Disease Burden ◽  
Four Dimensions ◽  
Post Transplant ◽  
Transplant Patients

ABSTRACT Objective: to compare the quality of life (QoL) of patients under dialysis and after kidney transplant; correlate the QoL of transplant patients to sociodemographic, morbid and spirituality/religiosity variables. Method: prospective study with a quantitative approach, with a sample of 27 patients who underwent peritoneal dialysis or dialysis undergoing kidney transplant. QoL and spirituality were assessed by the KDQOL-SF and WHOQOL-SRPB tools, being correlated with sociodemographic and economic variables. Results: the dimensions of total mental component, kidney disease effects and kidney disease burden showed significant improvement in the post-transplant period, with p <0.0004. There was a significant correlation between four dimensions of spirituality and seven dimensions of QoL; p ranged from 0.04 to 0.006. Conclusion: there was a significant improvement in QoL in the post-transplant period. The dimensions of spirituality: wholeness and integration, spiritual connection, wonder and inner peace were positively correlated with seven dimensions of QoL.

MO889COST OF ILLNESS OF CHRONIC KIDNEY DISEASE IN LEBANON: FROM THE SOCIETAL PERSPECTIVE

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Mabel Aoun ◽  
Elie Helou ◽  
Ghassan Sleilaty ◽  
Dania Nehme Chelala
Keyword(s):  
Chronic Kidney Disease ◽  
Peritoneal Dialysis ◽  
Kidney Disease ◽  
Kidney Transplant ◽  
Cost Of Illness ◽  
Medical Costs ◽  
Health Policies ◽  
Dialysis Patients ◽  
Transplant Patients ◽  
The Mean

Abstract Background and Aims Chronic Kidney Disease (CKD) is the 12th leading cause of death worldwide and a high societal burden. Cost-of-illness studies of CKD are scarce in developing countries. Identifying factors associated with the highest cost can help decision makers adapt health policies and sustain kidney health services, especially in limited resources' settings. This study aims to estimate the cost of illness of CKD in Lebanon, from the early stages of CKD until dialysis and kidney transplant and identify cost components related to the highest financial burden. Method This is a cross-sectional study of all CKD patients who presented to two nephrology clinics during the first two weeks of November 2020. The sample size required for the study to be representative was 154 patients. The medical and administrative records were reviewed to collect the demographics and CKD characteristics of patients as well as the direct medical costs (medications, diagnostic tests, hospitalizations, inpatient care, outpatient care), direct non-medical costs (transportation) and indirect costs (productivity losses) for one year between 1st June 2019 and 1st June 2020. Kruskal Wallis test was used to compare the costs between different CKD stages and categories. The study got the approval of the ethics committee of Saint-Joseph University. Results The sample included a total of 160 patients: 102 non-dialysis CKD patients, 40 hemodialysis, 8 peritoneal dialysis and 10 kidney transplant patients. Their mean age was 66.74 ±15.36 years, 57.5% were males and 42.5% diabetics. The mean number of daily medications was 8.75 ±3.38, mean frequency of blood tests per year 6.86 ±6.4 and mean number of hospital admissions per year 0.79 ±1.43. The mean total annual cost of CKD per patient across all categories was assessed at 19,900,164 ±27,893,591 Lebanese Pounds (1 $USD= 1515 LP in 2019). Statistical analysis showed a higher total cost among dialysis patients compared to other categories of CKD (p&lt;0.001), higher cost of medications in transplant patients (p&lt;0.001) and higher cost of technique modality in peritoneal dialysis patients (p&lt;0.001). These differences are summarized in Figure 1. Conclusion Similar to previous studies from other countries, this cost of illness analysis showed a high burden of dialysis annual costs compared to non-dialysis CKD and transplant patients. It revealed as well a great burden of medications' costs at the level of dialysis and transplantation. It is thus crucial that governments and health policies in low- and middle-income countries target interventions that prevent end-stage kidney disease, reduce medications' costs and most of all create programs that encourage kidney transplantation.

Validation of the Kidney Disease Quality of Life-Short Form questionnaire in kidney transplant patients

2006 ◽  
Vol 60 (5) ◽  
pp. 495-504 ◽  
Author(s):  
Szabolcs Barotfi ◽  
Miklos Zs. Molnar ◽  
Csilla Almasi ◽  
Agnes Zs. Kovacs ◽  
Adam Remport ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Kidney Transplant ◽  
Short Form ◽  
Transplant Patients ◽  
Kidney Transplant Patients
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