Changes in serum cystatin C, creatinine, and C-reactive protein after cardiopulmonary bypass in patients with normal preoperative kidney function

Nephrology ◽  
2016 ◽  
Vol 21 (6) ◽  
pp. 519-525 ◽  
Author(s):  
Anders S. Svensson ◽  
John-Peder Escobar Kvitting ◽  
Csaba P. Kovesdy ◽  
Ingemar Cederholm ◽  
Zoltán Szabó
Keyword(s):  
Cardiopulmonary Bypass ◽  
Kidney Function ◽  
Cystatin C ◽  
C Reactive Protein ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Reactive Protein

scholarly journals Comparison of Different Measures of Fat Mass and Their Association with Serum Cystatin C Levels

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Boon Wee Teo ◽  
Jonathan J. H. Soon ◽  
Qi Chun Toh ◽  
Hui Xu ◽  
Jialiang Li ◽  
...  
Keyword(s):  
Cystatin C ◽  
Information Criterion ◽  
C Reactive Protein ◽  
Multivariate Models ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Percentage Body Fat ◽  
Reactive Protein ◽  
Skin Fold ◽  
Triceps Skin Fold

Introduction. Cystatin C (CysC) is a glomerular filtration rate (GFR) marker affected by GFR and obesity. Because percentage body fat (%BF) distribution is affected by ethnicity, different measures of %BF may improve CysC prediction. This study aims to create multivariate models that predict serum CysC and determine which %BF metric gives the best prediction. Methods. Serum CysC was measured by nephelometric assay. We estimated %BF by considering weight, body mass index, waist-hip ratio, triceps skin fold, bioimpedance, and Deurenberg and Yap %BF equations. A base multivariate model for CysC was created with a %BF metric added in turn. The best model is considered by comparing P values, R2, Akaike information criterion (AIC), and Bayesian information criterion (BIC). Results. There were 335 participants. Mean serum CysC and creatinine were 1.27 mg/L and 1.44 mg/dL, respectively. Variables for the base model were age, gender, ethnicity, creatinine, serum urea, c-reactive protein, log GFR, and serum albumin. %BF had a positive correlation with CysC. The best model for predicting CysC included bioimpedance-derived %BF (P=0.0011), with the highest R2 (0.917) and the lowest AIC and BIC (−371, −323). Conclusion. Obesity is associated with CysC, and the best predictive model for CysC includes bioimpedance-derived %BF.

scholarly journals Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions

2018 ◽  
Vol 37 (4) ◽  
pp. 434-440 ◽  
Author(s):  
Selda Telo ◽  
Mutlu Kuluöztürk ◽  
Figen Deveci ◽  
Gamze Kırkıl ◽  
Önsel Öner ◽  
...  
Keyword(s):  
Cystatin C ◽  
Diagnostic Value ◽  
Serum Urea ◽  
C Reactive Protein ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Positive Correlation ◽  
Reactive Protein ◽  
Cell Counts ◽  
Significant Difference

SummaryBackground:The aim of this study was to determine the level of serum cystatin C (CysC) in patients with Chronic Obstructive Pulmonary Disease (COPD) during exacerbation and stable periods and to investigate its potential diagnostic value and the relationship between CysC levels and the pulmonary function test (PFT).Methods:One hundred twenty-six patients with COPD (68 in stable periods, 58 during exacerbation periods) and 50 healthy subjects were included in the study. PFT, body mass index (BMI), white blood cell counts, C-reactive protein (CRP), serum urea and creatinine levels were evaluated in both groups of patients. CysC levels were measured in all participants.Results:Serum CysC levels were statistically higher in both COPD groups than the control group (p<0.001 for both) although there was no statistically significant difference between COPD groups (p>0.05). CysC levels showed negative correlation with forced expiratory volume in 1 second (FEV1) and a positive correlation with C-reactive protein (CRP) levels in patients with stable COPD. There was a positive correlation between serum CysC levels and serum urea, creatinine, CRP levels in patients with COPD exacerbation (r=0.333, p=0.011; r=0.260, p=0.049; r=0.414, p<0.01 respectively). When stable COPD and control groups were evaluated, serum CysC had an area under the curve (AUC) in the receiver operating characteristic (ROC) curve of 0.951 (0.909–0.994 95% CI: p<0.001).Conclusions:Our results showed that CysC levels increased in both COPD groups. Increased CysC levels may be related with lung function decline and inflammation in COPD patients. In addition, CysC levels may be a potential indicator for the diagnosis of COPD.

scholarly journals Comparison of serum cystatin C and creatinine changes after cardiopulmonary bypass in patients with normal preoperative kidney function

2013 ◽  
Vol 45 (6) ◽  
pp. 1597-1603 ◽  
Author(s):  
Anders S. Svensson ◽  
Csaba P. Kovesdy ◽  
John-Peder Escobar Kvitting ◽  
Magnus Rosén ◽  
Ingemar Cederholm ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Kidney Function ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Moses Temidayo Abiodun ◽  
Nosakhare J. Iduoriyekemwen ◽  
Phillip O. Abiodun
Keyword(s):  
Kidney Disease ◽  
Hiv Infection ◽  
Kidney Function ◽  
Cystatin C ◽  
Mean Value ◽  
Control Group ◽  
Healthy Children ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
The Mean

Background. Human immunodeficiency virus (HIV) is now a confirmed risk factor for kidney disease with an increased burden in persons of African descent.Method. We measured the serum cystatin C levels of 205 ART-naive, HIV-infected children by an ELISA technique and compared them with the levels of apparently healthy children.Result. The mean ± SD serum cystatin C level of children with HIV infection was 1.01 ± 0.44 mg/L, significantly higher than the mean value in the control group, that is, 0.72 ± 0.20 mg/L (P=0.000). The mean ± SD cystatin C-based estimated GFR of children with HIV infection was 102.7 ± 31.0 mL/min/1.73 m2, significantly lower than 126.9 ± 28.5 mL/min/1.73 m2in the control group, (P=0.014). A significantly higher proportion of HIV-infected children compared to controls had eGFR < 90 mL/min/1.73 m2(21.5% versus 5.4%;P=0.00). The prevalence of chronic kidney disease (CKD) among the HIV-infected children was 10.7%. The cystatin C-based eGFR of the HIV-infected children ≥5 years old correlated positively with their CD4 count (r=0.23;  P=0.022).Conclusion. There is a high prevalence of CKD among HIV-infected children, requiring regular monitoring of their kidney function using a cystatin C-based method.

UP-01.164 Serum Cystatin C: A Marker of Early Kidney Function Damage After Tumor Nephrectomy?

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S241
Author(s):  
M. Schmid ◽  
W. Tenschert ◽  
B. Schwaiger ◽  
F. Chun ◽  
M. Fisch
Keyword(s):  
Kidney Function ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Tumor Nephrectomy

scholarly journals Serum Cystatin C Is an Early Predictive Biomarker of Acute Kidney Injury after Pediatric Cardiopulmonary Bypass

2010 ◽  
Vol 5 (9) ◽  
pp. 1552-1557 ◽  
Author(s):  
Catherine D. Krawczeski ◽  
Rene G. Vandevoorde ◽  
Thelma Kathman ◽  
Michael R. Bennett ◽  
Jessica G. Woo ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiopulmonary Bypass ◽  
Cystatin C ◽  
Kidney Injury ◽  
Predictive Biomarker ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Serum Creatinine and Serum Cystatin C are Both Relevant Renal Markers to Estimate Vancomycin Clearance in Critically Ill Neonates

2021 ◽  
Vol 12 ◽  
Author(s):  
Stéphanie Leroux ◽  
Valérie Biran ◽  
John van den Anker ◽  
Verena Gotta ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Intensive Care ◽  
Serum Creatinine ◽  
Kidney Function ◽  
Cystatin C ◽  
Therapeutic Drug ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Final Model ◽  
Model Based

Purpose: Serum creatinine (SCr) is used as a marker of kidney function to guide dosing of renally eliminated drugs. Serum Cystatin C (S-CysC) has been suggested as a more reliable kidney marker than SCr in adults and children. Purpose of this study was to investigate S-CysC as alternative renal marker to SCr for estimating vancomycin clearance in neonates undergoing intensive care.Methods: Vancomycin pharmacokinetics (PK), SCr and S-CysC data were collected in patients undergoing vancomycin treatment in the neonatal intensive care unit of Robert Debré Hospital - Paris. A population PK analysis was performed utilizing routine therapeutic drug monitoring samples. S-CysC and SCr were compared as covariates on vancomycin clearance using stepwise covariate modeling (forward inclusion [p &lt; 0.05] and backward elimination [p &lt; 0.01]). Model performance was evaluated by graphical and statistical criteria.Results: A total of 108 vancomycin concentrations from 66 patients (postmenstrual age [PMA] of 26–46 weeks) were modeled with an allometric one-compartment model. The median (range) values for SCr and S-CysC were 41 (12–153) µmol/l and 1.43 (0.95–2.83) mg/l, respectively. Following stepwise covariate model building, SCr was retained as single marker of kidney function (after accounting for weight and PMA) in the final model. Compared to the final model based on SCr, the alternative model based on S-CysC showed very similar performance (e.g. BIC of 578.3 vs. 576.4) but included one additional covariate: impact of mechanical ventilation on vancomycin clearance, in addition to the effects of size and maturation.Conclusion: ill neonates. However, if using S-CysC for this purpose mechanical ventilation needs to be taken into account.

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