Cell-mediated and humoral acute vascular rejection and graft loss: A registry study

Nephrology ◽  
2016 ◽  
Vol 21 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Rachel ZC Teo ◽  
Germaine Wong ◽  
Graeme R Russ ◽  
Wai H Lim
Keyword(s):  
Graft Loss ◽  
Registry Study ◽  
Vascular Rejection ◽  
Acute Vascular Rejection

scholarly journals Early Posttransplant Isolated v1 Lesion Does Not Need to Be Treated and Does Not Lead to Increased Fibrosis

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Irfan Moinuddin ◽  
Bijin Thajudeen ◽  
Amy Sussman ◽  
Machaiah Madhrira ◽  
Erika Bracamonte ◽  
...  
Keyword(s):  
Conservative Management ◽  
Graft Loss ◽  
Graft Function ◽  
Close Monitoring ◽  
Kidney Allograft ◽  
Vascular Rejection ◽  
Interstitial Inflammation ◽  
Acute Vascular Rejection ◽  
Allograft Function ◽  
Over Time

Acute vascular rejection (AVR) is characterized by intimal arteritis in addition to tubulitis and interstitial inflammation. It is associated with a poorer prognosis compared to tubulointerstitial rejection (AIR) and AVR is associated with a higher rate of graft loss than AIR. The prognosis and treatment of arteritis without tubulitis and interstitial inflammation (isolated v1 lesion) are still controversial. We report a case of a patient who had a biopsy of the kidney allograft for evaluation of slow graft function. The biopsy revealed an isolated v1 lesion. However, we chose not to augment immunosuppression. The patient’s kidney allograft function improved over time with close monitoring. Repeat biopsy a year later showed no evidence of endothelialitis and relatively unchanged fibrosis and no other abnormalities. Although it is suggested that most cases of isolated v1 lesions will respond to corticosteroids or T cell depleting therapies, some cases will improve with conservative management. Further studies are needed to determine which cases could be managed conservatively.

scholarly journals GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels

2018 ◽  
Vol 25 (5) ◽  
pp. e12391 ◽  
Author(s):  
Hironosuke Watanabe ◽  
Hisashi Sahara ◽  
Shunichiro Nomura ◽  
Tatsu Tanabe ◽  
Dilrukshi K. Ekanayake-Alper ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Transgenic Expression ◽  
Vascular Rejection ◽  
Acute Vascular Rejection ◽  
Porcine Blood

Postoperative production of anti-donor antibody and early graft loss due to vascular rejection in renal transplantation

1998 ◽  
Vol 30 (7) ◽  
pp. 2963 ◽  
Author(s):  
M Abe ◽  
A Sannomiya ◽  
T Koike ◽  
S Sato ◽  
J Sageshima ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Graft Loss ◽  
Vascular Rejection ◽  
Early Graft

Transgenic Expression of hCD47 on Vessels in Porcine GalTKO Lung Grafts in Baboons may Mitigate Acute Vascular Rejection in Baboons

2018 ◽  
Vol 102 ◽  
pp. S313
Author(s):  
Hironosuke Watanabe ◽  
Shunichiro Nomura ◽  
Hisashi Sahara ◽  
Thomas Pomposelli ◽  
Yuichi Ariyoshi ◽  
...  
Keyword(s):  
Transgenic Expression ◽  
Vascular Rejection ◽  
Acute Vascular Rejection

Patients with steroid refractory acute vascular rejection develop agonistic antibodies targeting angiotensin II type 1 receptor

2003 ◽  
Vol 35 (6) ◽  
pp. 2104-2105 ◽  
Author(s):  
D Dragun ◽  
J.H Bräsen ◽  
C Schönemann ◽  
L Fritsche ◽  
K Budde ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Vascular Rejection ◽  
Acute Vascular Rejection ◽  
Steroid Refractory
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