NOS3 tagSNPs does not modify the chronic kidney disease progression in autosomal dominant polycystic kidney disease

Nephrology ◽  
2014 ◽  
Vol 19 (9) ◽  
pp. 537-541 ◽  
Author(s):  
Gnanasambandan Ramanathan ◽  
Soundararajan Periyasamy ◽  
Bhaskar VKS Lakkakula
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Progression ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Chronic Kidney Disease Progression ◽  
Kidney Disease Progression ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals Predictors of Autosomal Dominant Polycystic Kidney Disease Progression

2014 ◽  
Vol 25 (11) ◽  
pp. 2399-2418 ◽  
Author(s):  
Robert W. Schrier ◽  
Godela Brosnahan ◽  
Melissa A. Cadnapaphornchai ◽  
Michel Chonchol ◽  
Keith Friend ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Disease Progression ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Kidney Disease Progression ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals P0037POPULATION CHARACTERISTICS ACROSS AN EXPANDED POOLED DATABASE OF MULTIPLE AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE CLINICAL STUDIES

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Xiaolei Zhou ◽  
Eric Davenport ◽  
John Ouyang ◽  
Molly Hoke ◽  
Diana Garbinsky ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Progression ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Extension Study ◽  
Polycystic Kidney ◽  
History Of ◽  
Baseline Characteristics ◽  
Autosomal Dominant Polycystic Kidney

Abstract Background and Aims Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and the fourth-leading cause of kidney failure. Over the past two decades, various studies have been conducted to characterize the natural history of ADPKD and investigate impacts of potential treatments on disease progression. Previously, we created a pooled longitudinal database of unique subjects from nine studies to evaluate and analyze outcomes. The database was expanded to include data from two recent tolvaptan (TOL) trials (156-13-210 and 156-13-211). Here, we describe the baseline characteristics of the expanded pooled population. Method Data from 11 ADPKD studies (from 2001 to 2018, sponsored by Otsuka or National Institutes of Health) were combined and divided into two groups: TOL and standard of care (SOC). TOL consisted of trial subjects initiating treatment in one of seven trials (156-04-250, 156-04-251, 156-06-260, 156-09-284, 156-09-290, 156-08-271, and 156-13-210); SOC included subjects from placebo arms of two TOL randomized trials (156-04-251 and 156-09-290), all standard blood pressure control arms in the HALT-PKD trials, and subjects from two observational studies (156-10-291 and CRISP). Subjects in the placebo arm of study 156-13-210 received TOL for 5 weeks before randomization and were therefore included in the TOL group. Eligible subjects who completed an early TOL study continued TOL treatment in the extension study 156-08-271 and/or in a second extension study 156-13-211. Estimated glomerular filtration rate (eGFR) was calculated in all studies using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Total kidney volume (TKV) was measured by magnetic resonance imaging and available in all studies except 156-13-210, 156-13-211, and HALT-PKD study B. Results The pooled analysis included 7,117 eligible subjects (TOL: 2,928; SOC: 4,189) from the United States (47.5%) and other countries. The two cohorts had similar age (mean age, 43.6 vs. 44.1 years) and sex distribution (50.5% male vs. 45.2% male). The TOL group had more white subjects (90.5% vs. 80.7%) and fewer Hispanic subjects (4.0% vs. 12.6%), a lower baseline mean eGFR (60 vs. 70 mL/min/1.73 m2), more in chronic kidney disease (CKD) stage 3 or above (58.1% vs. 41.0%), and more frequent history of signs of rapid disease progression (e.g., nephrolithiasis, hematuria, urinary tract infection). Among 4,917 subjects with TKV assessments, mean baseline TKV was higher in the TOL group (1,817 mL) compared with SOC (1,627 mL). Conclusion In this large, longitudinal database of unique subjects with ADPKD, distinct differences exist in some baseline characteristics of the TOL and SOC groups. Compared with the previous database, the expanded database doubled the size of the TOL group and included more subjects who were older and with advanced chronic kidney disease stage. This database provides a diverse ADPKD population to assess outcomes.

scholarly journals FP047URINARY PROTEOMIC BIOMARKERS, A POWERFUL TOOL FOR PROGNOSIS OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE PROGRESSION

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii80-iii80
Author(s):  
Martin Pejchinovski ◽  
Justyna Siwy ◽  
Jochen Metzger ◽  
Harald Mischak ◽  
Vera Jankowski ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Disease Progression ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Kidney Disease Progression ◽  
Autosomal Dominant Polycystic Kidney
Sign in / Sign up

Export Citation Format

Share Document