Urinary cystatin C levels as a diagnostic and prognostic biomarker in patients with acute kidney injury

Nephrology ◽  
2013 ◽  
Vol 18 (4) ◽  
pp. 256-262 ◽  
Author(s):  
Moo Yong Park ◽  
Soo Jeong Choi ◽  
Jin Kuk Kim ◽  
Seung Duk Hwang ◽  
Yong Wha Lee
Keyword(s):  
Acute Kidney Injury ◽  
Cystatin C ◽  
Prognostic Biomarker ◽  
Kidney Injury ◽  
Urinary Cystatin C

Myeloma progression and urinary gammaglobulin affect the urinary cystatin C to diagnose acute kidney injury in multiple myeloma

2014 ◽  
Vol 81 (05) ◽  
pp. 345-349 ◽  
Author(s):  
Jae Seok Kim ◽  
Jae Won Yang ◽  
Hyeoncheol Park ◽  
Young Sub Kim ◽  
Jun Young Lee ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Acute Kidney Injury ◽  
Cystatin C ◽  
Kidney Injury ◽  
Urinary Cystatin C

scholarly journals Cystatin C in the diagnostics of acute kidney injury after heart transplantation

2017 ◽  
Vol 19 (1) ◽  
pp. 17-21
Author(s):  
A. G. Strokov ◽  
Ya. L. Poz ◽  
V. N. Poptsov ◽  
A. O. Shevchenko ◽  
N. P. Shmerko
Keyword(s):  
Acute Kidney Injury ◽  
Heart Transplantation ◽  
Cystatin C ◽  
Kidney Injury ◽  
Circulatory Support ◽  
Tubular Necrosis ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage ◽  
Urinary Cystatin C

Aim. To examine the assumption that significant concentrations of cystatin C in urine are the manifestation of the tubular necrosis and, respectively, the severity of kidney damage after heart transplantation (HTx).Materials and methods. In this study we evaluated 33 heart recipients (6 women and 27 men, aged from 24 to 68 years old) who had risk factors of acute kidney injury: serum creatinine level >113 μmol/l and/or mechanical circulatory support requirement (20 patients, in 14 cases before HTx). Cystatin C concentration in serum and in urine was measured by DyaSis particle-enhanced immunoturbidimetric assay test «Cystatin C FS».Results. Recipients were divided into two groups according to the levels of cystatinuria. In the group with the significant (more than 0.18 mg/l) urinary cystatin C concentrations the requirement of renal replacement therapy (RRT) was 2.5-fold higher, and the mean duration of RRT was more than 10-fold longer. In 2 patients with the significant cystatinuria acute kidney injury (AKI) has transformed into end-stage renal disease (ESRD).Conclusion. Due to data obtained we may suppose that significant concentrations of cystatin C in urine are the marker of the tubular necrosis with the prolonged RRT requirement. Further studies are needed to justify this relationship.

scholarly journals Urinary Cystatin C and Acute Kidney Injury After Cardiac Surgery

2013 ◽  
Vol 61 (5) ◽  
pp. 730-738 ◽  
Author(s):  
Jay L. Koyner ◽  
Amit X. Garg ◽  
Michael G. Shlipak ◽  
Uptal D. Patel ◽  
Kyaw Sint ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cystatin C ◽  
Kidney Injury ◽  
Urinary Cystatin C

scholarly journals Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery

2008 ◽  
Vol 74 (8) ◽  
pp. 1059-1069 ◽  
Author(s):  
Jay L. Koyner ◽  
Michael R. Bennett ◽  
Elaine M. Worcester ◽  
Qing Ma ◽  
Jai Raman ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cystatin C ◽  
Kidney Injury ◽  
Cardiothoracic Surgery ◽  
Early Biomarker ◽  
Urinary Cystatin C

scholarly journals Assessment of Cell-Cycle Arrest Biomarkers to Predict Early and Delayed Acute Kidney Injury

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Max Bell ◽  
Anders Larsson ◽  
Per Venge ◽  
Rinaldo Bellomo ◽  
Johan Mårtensson
Keyword(s):  
Acute Kidney Injury ◽  
Cystatin C ◽  
Kidney Injury ◽  
Predictive Performance ◽  
Operating Characteristics ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Cycle Arrest ◽  
Neutrophil Gelatinase ◽  
Urinary Cystatin C ◽  
Urine Levels

Purpose. To assess urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor binding protein 7 ([TIMP-2]·[IGFBP7]), urinary neutrophil gelatinase-associated lipocalin (NGAL), and urinary cystatin-C as acute kidney injury predictors (AKI) exploring the association of nonrenal factors with elevated biomarker levels.Methods. We studied 94 patients with urine collected within 48 hours of ICU admission and no AKI at sampling. AKI was defined by the Kidney Disease: Improving Global Outcomes criteria. Predictive performance was assessed by the area under the receiver operating characteristics (ROC) curve. Associations between biomarkers and clinical factors were assessed by multivariate linear regression.Results. Overall, 19 patients (20%) developed AKI within 48 hours. [TIMP-2]·[IGFBP7], NGAL, or cystatin-C admission levels did not differ between patients without AKI and patients developing AKI. [TIMP-2]·[IGFBP7], NGAL, and cystatin-C were poor AKI predictors (ROC areas 0.34–0.51). Diabetes was independently associated with higher [TIMP-2]·[IGFBP7] levels (P=0.02) but AKI was not (P=0.24). Sepsis was independently associated with higher NGAL (P<0.001) and cystatin-C (P=0.003) levels.Conclusions. Urinary [TIMP-2]·[IGFBP7], NGAL, and cystatin-C should be used cautiously as AKI predictors in general ICU patients since urine levels of these biomarkers are affected by factors other than AKI and their performance can be poor.

URINARY CYSTATIN C IN PATIENTS WITH ACUTE KIDNEY INJURY FOLLOWING CARDIAC SURGERY.

2007 ◽  
Vol 55 (2) ◽  
pp. S348-S349
Author(s):  
J. Koyner ◽  
S. Trevino ◽  
D. Konczal ◽  
E. Worcester ◽  
J. Raman ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cystatin C ◽  
Kidney Injury ◽  
Urinary Cystatin C
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