Baseline characteristics of patients from ongoing post‐marketing surveillance, evaluating the real‐world efficacy and safety of edaravone, a novel, free radical scavenger, for amyotrophic lateral sclerosis patients in Japan (SUNRISE Japan)

2020 ◽  
Vol 8 (5) ◽  
pp. 261-269
Author(s):  
Satoshi Yuki ◽  
Kaoru Ishizaki ◽  
Hanami Yoshioka ◽  
Hidekazu Nakamura ◽  
Manabu Hirai ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Free Radical ◽  
Real World ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Efficacy And Safety ◽  
Post Marketing Surveillance ◽  
Post Marketing ◽  
Baseline Characteristics ◽  
Lateral Sclerosis

OPTIMASI KONDISI EKSTRAKSI SENYAWA AKTIF ANTIOKSIDAN DARI BIJI ANGGUR

2019 ◽  
Vol 3 (2) ◽  
pp. 35
Author(s):  
Kartini Kartini ◽  
Azminah Azminah
Keyword(s):  
Free Radical ◽  
Optimum Condition ◽  
Active Compound ◽  
Grape Seed ◽  
Free Radical Scavenger ◽  
Water Bath ◽  
Radical Scavenger ◽  
Optimum Conditions ◽  
Ethanolic Solution ◽  
Reduced Pressure

In order to prepare standardized extract, optimization of extraction conditions of grape seed has been done. These conditions are type of menstrum (50, 70 and 96% of ethanolic solution), length of extraction (1, 2 and 4 hours) also method of evaporation (reduced pressure and opened air). Activity on free radical scavenger used as parameters to determine optimum conditions. Based on EC50 (concentration which scavenge 50% amount of free radical) can be concluded that optimum condition for extracting antioxidant active compound from grape seed are 70% ethanolic solution as menstrum, length of extraction 1 hour and evaporation on opened air use water bath.

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