Ischemic stroke associated with adenomyosis with marked elevation of serum CA125 level

2020 ◽  
Vol 8 (4) ◽  
pp. 196-198
Author(s):  
Sunao Takahashi ◽  
Zen Kobayashi ◽  
Emi Kijima ◽  
Shoichiro Ishihara ◽  
Hiroyuki Tomimitsu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Marked Elevation ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level

scholarly journals Diagnostic value of risk malignancy index (RMI) for detection of malignancies in clinically diagnosed ovarian masses and to evaluate the validity of individual constituent parameter of risk malignancy index

2019 ◽  
Vol 8 (4) ◽  
pp. 1558
Author(s):  
Jenitha B. ◽  
Subbiah M.
Keyword(s):  
Malignant Tumors ◽  
Menopausal Status ◽  
Research Centre ◽  
Ca 125 ◽  
Ovarian Mass ◽  
Individual Parameter ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level ◽  
Ovarian Masses

Background: Pre-operative knowledge regarding the nature of ovarian mass is necessary in order to plan surgery. Risk malignancy index (RMI) is a simple scoring system based on three factors serum CA 125, USG score and menopausal status. The RMI was interpreted as 1) score >250=high risk, 2) 25-250=intermediate risk, 3) score <25=low risk. The objective of the study was to evaluate risk malignancy index (RMI) in pre-operatively clinically diagnosed ovarian mass and to compare the validity of individual parameter in RMI i.e. menopausal status, serum CA 125 and USG score to differentiate the nature of clinically diagnosed ovarian masses as benign or malignant.Methods: This was an observational study conducted in the Department of obstetrics and gynaecology, Trichy SRM Medical College and Research Centre, Trichy from January 2017 to January 2018 with a sample size of 77 cases with clinical diagnosis of ovarian mass admitted for surgery. The validity of RMI and validity of individual parameters were calculated and compared.Results: A total of 77 patients with ovarian tumors were enrolled in this study. According to the histological examination of the surgical specimens of the 77 women, 27.3% (n=21) had malignant tumors and 67.7% (n=56) had benign disease. Most common benign tumour was serous cystadenoma and the most common malignant tumour was mucinous cystadenocarcinoma. Among 77 patients, 42.85% (n=33) were postmenopausal, 44.15% (n=34) had USG score of 4, 27.27% (n=21) had serum CA125 level >cut-off values and 27.27% (n=21) had RMI >250. In cases where RMI>250, 18 out of 21 were malignant. In cases where USG score was 4, 19 out of 34 were malignant. Of the cases where serum CA125 level was > cut-off values 16 out of 21 were found to be malignant. RMI showed better sensitivity of 85.71%, specificity of 94.64%, PPV of 85.71%, NPV of 94.64% and diagnostic accuracy of 92.20%.Conclusions: RMI is highly valuable and reliable in differentiating benign and malignant ovarian lesions and facilitates selection of cases for conservative management and oncology referral.

Prechemotherapy serum CA125 level as a predictor of survival outcome in epithelial carcinoma of the ovary

1991 ◽  
Vol 3 (1) ◽  
pp. 32-36 ◽  
Author(s):  
N.G.P. Davidson ◽  
S. Khanna ◽  
P.H. Kirwan ◽  
D. Bircumshaw
Keyword(s):  
Survival Outcome ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level ◽  
Carcinoma Of The Ovary

Significance of the Serum CA125 Level in Recurrent Ovarian Cancer

2010 ◽  
Vol 18 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Haruo Nishimura ◽  
Masamichi Tashiro ◽  
Kinya Hamaguchi ◽  
Yasuyuki Kiyozuka ◽  
Hiroshi Ide ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Recurrent Ovarian Cancer ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level

scholarly journals Ovarian fibroma/fibrothecoma with elevated serum CA125 level

Medicine ◽  
2018 ◽  
Vol 97 (34) ◽  
pp. e11926 ◽  
Author(s):  
Yuanming Shen ◽  
Yun Liang ◽  
Xiaodong Cheng ◽  
Weiguo Lu ◽  
Xing Xie ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Ovarian Fibroma ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level

scholarly journals Relationship Between Serum CA125 Level with Malnutrition and Functional Parameters in Peritoneal Dialysis Patients

2018 ◽  
Vol 7 (1) ◽  
pp. 1-8
Author(s):  
Nader Nori Majelan ◽  
Hamideh Shajari ◽  
Nasrollah Bashardost ◽  
Ahmad Shajari ◽  
Maryam Sadat Moddarresi ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Dialysis Patients ◽  
Functional Parameters ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level

Estimation of probability of malignancy using a logistic model combining color Doppler ultrasonography, serum CA125 level in women with a pelvic mass

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 92-98 ◽  
Author(s):  
A. S. Mousavi ◽  
S. Borna ◽  
S. Moeinoddini
Keyword(s):  
Predictive Value ◽  
Scoring System ◽  
Malignant Tumors ◽  
Color Doppler ◽  
Transvaginal Ultrasound ◽  
Resistance Index ◽  
Doppler Imaging ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level

The goal of this study was to develop a scoring system using combination of Doppler characterization of pelvic/ovarian lesions and serum CA125 level. Our purpose was to maximize the preoperative discrimination between benign and malignant entities. In a prospective study, a total of 101 patients were evaluated preoperatively using a standard transvaginal ultrasound and color Doppler imaging with pulse spectral analysis and serum CA125 level within a week prior to surgery. The variables that were analyzed by the multivariate logistic regression method are as follows: tumor structure, ascites, presence of septum, the peak systolic velocity (PSV), the resistance index (RI), and serum CA125 level. Of the 101 patients qualified for the study, 48 patients were diagnosed with benign (47.5%) and 53 (52.5%) with malignant tumors. Each criterion used alone provides statistically significant discrimination between benign and malignant tumors. Four criteria could be combined in a malignancy score which is calculated using the product of the serum CA125 level (1 if CA125 ≥40 U/mL and 0 if CA125 <40 U/mL), the result of sonography for presence of septum in tumor (1 if there was septum ≥3 mm, 0 if there was no septum or <3 mm), result of Doppler flow imaging as RI (1 if RI ≤0.5 and 0 if RI >0.5) and the PSV (1 if PSV ≥40 cm/s and 0 if PSV <40 cm/s). This scoring system devised was statistically more effective discriminator between cancer and benign lesions than formal methods. Using malignancy score cutoff level of two, the sensitivity was 98% (CI 88.62–99.9.), the specificity was 85% (CI 71.62–93.45), the positive predictive value was 87.5%, and the negative predictive value was 97.6%. Area under curve of receiver operative characteristic curves was 0.987 (CI 0.971–1.004). These values were statistically more significant than those obtained from the independent use of RI, PSV, or serum CA125 level at their optimum decision values (P < 0.05). There is a need for a prospective evaluation of this score using a larger sample of patients.

scholarly journals Serum CA125 level is a good prognostic indicator in lung cancer

1990 ◽  
Vol 62 (4) ◽  
pp. 676-678 ◽  
Author(s):  
Y Kimura ◽  
T Fujii ◽  
K Hamamoto ◽  
N Miyagawa ◽  
M Kataoka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Prognostic Indicator ◽  
Ca125 Level ◽  
Serum Ca125 ◽  
Serum Ca125 Level
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