Area postrema syndrome as a debut of neuromyelitis optica spectrum disorders

2019 ◽  
Vol 7 (5) ◽  
pp. 301-302
Author(s):  
Irene Treviño‐Frenk ◽  
Rogelio Dominguez‐Moreno ◽  
Dioselina Panama Tristan‐Samaniego ◽  
David Davila‐Sosa ◽  
Gladys Vanessa Barriga‐Maldonado
Keyword(s):  
Neuromyelitis Optica ◽  
Area Postrema ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spectrum Disorders

Area postrema syndrome: Another feature of anti-GFAP encephalomyelitis

2019 ◽  
Vol 26 (2) ◽  
pp. 253-255 ◽  
Author(s):  
Jonathan Ciron ◽  
Fanny Sourdrille ◽  
Damien Biotti ◽  
Thierry Tchoumi ◽  
Anne Ruiz ◽  
...  
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Neuromyelitis Optica ◽  
Area Postrema ◽  
Acidic Protein ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spectrum Disorders

Anti–Glial fibrillary acidic protein (GFAP) encephalomyelitis is a recently described entity and while the spectrum of this disease has been explored, further research is needed to fully describe its phenotype. Area postrema syndrome (APS) is usually associated with neuromyelitis optica spectrum disorders (NMOSDs), whereas no case of APS has been previously reported with anti-GFAP encephalomyelitis. In this article, we report a case of APS in a 41-year-old woman in the context of anti-GFAP encephalomyelitis. This case was not associated with additional anti-AQP4 IgG and therefore extends the clinico-radiological spectrum of anti-GFAP encephalomyelitis.

scholarly journals Consensus of expert advices on routing, diagnosis, and management of patients with neuromyelitis optica spectrum disorders

2021 ◽  
Vol 13 (5) ◽  
pp. 140-147
Author(s):  
A. N. Boyko ◽  
K. Z. Bakhtiyarova ◽  
L. V. Brylev ◽  
M. N. Zakharova ◽  
D. S. Kasatkin ◽  
...  
Keyword(s):  
Medical Care ◽  
Neuromyelitis Optica ◽  
Russian Federation ◽  
Area Postrema ◽  
Economic Feasibility ◽  
Medical Community ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Central Nervous System Damage ◽  
The Russian Federation ◽  
Spectrum Disorders

Neuromyelitis optica spectrum disorders (NMOSDs) are autoimmune inflammatory disorders accompanied by central nervous system damage, widespread immunemediated demyelination, and axonal damage, involving mainly the optic nerves, spinal cord, and area postrema. The diagnostic capabilities, administration and routing of patients, and therapeutic approaches to this disease need to be improved. During several expert councils held in 2019–2021 in different regions of the Russian Federation, we discussed multiple issues related to various aspects of medical care for patients with NMOSDs. As a result, the experts developed further steps necessary to improve the medical care to these patients: to write and publish clinical guidelines for the diagnosis and treatment of NMOSDs; to consider the possibility of optimizing the NMOSDs diagnostic program including the aquaporin-4 antibodies (AQP4-IgG) testing; to evaluate the implementation of a set of measures aimed at including the corresponding laboratory investigations into the system of state guarantees (together with the institutions of the Ministry of Health of Russia), if there is clinical and economic feasibility; to include the issues of timely NMOSDs evaluation in educational programs initiated by the scientific medical community, in order to raise awareness of primary care neurologists in relation to the clinical and neuroimaging signs of probable NMOSDs; to assess the possibility of introducing routing schemes for patients with NMOSDs at the regional level; to work out a decision on the collection of NMOSDs epidemiological and clinical data in the Russian Federation.

scholarly journals AREA POSTREMA SYNDROME – A CHALLENGE FOR DIFFERENTIAL DIAGNOSIS BETWEEN MULTIPLE SCLEROSIS AND NEUROMYELITIS OPTICA SPECTRUM DISORDERS

2017 ◽  
Vol 16 (4) ◽  
pp. 154-157
Keyword(s):  
Neuromyelitis Optica ◽  
Area Postrema ◽  
Brain Mri ◽  
Clinical Findings ◽  
The Body ◽  
Oligoclonal Bands ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Peripheral Facial Palsy ◽  
Csf Analysis ◽  
Spectrum Disorders

Area postrema syndrome (APS) manifested with hiccups, nausea and vomiting is one of the core clinical findings in neuromyelitis optica spectrum disorders (NMOSD). We report the case of a 41-year-old woman, with no significant prior medical history, who presented with left upper limb paresthesias. The patient revealed two prior episodes, one 5 years ago, with paresthesias and mild paresis on the right side of the body and the other a few month ago, with right peripheral facial palsy, right facial anesthesia, headache, nausea and emesis. This led us to suspect area postrema syndrome and, possibly, NMOSD. Brain MRI did not show typical lesions for NMOSD, apart from a left periaqueductal lesion. Other potential diagnoses were excluded through laboratory workup. Serum anti-AQP4 antibody were negative, while CSF analysis was positive for oligoclonal bands. Based on clinical and paraclinical findings, a diagnosis of MS was made. This case illustrated that APS may also be present in MS and not only in NMOSD.

P 855. Epidemiology of Neuromyelitis Optica Spectrum Disorders in Children and Adolescents

2018 ◽  
Author(s):  
Christian Lechner ◽  
Matthias Baumann ◽  
Eva-Maria Hennes ◽  
Kathrin Schanda ◽  
Markus Reindl ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Neuromyelitis Optica ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spectrum Disorders

Olfactory dysfunction in neuromyelitis optica spectrum disorders

2015 ◽  
Vol 262 (8) ◽  
pp. 1890-1898 ◽  
Author(s):  
Lin-Jie Zhang ◽  
Ning Zhao ◽  
Ying Fu ◽  
Da-Qi Zhang ◽  
Jing Wang ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Olfactory Dysfunction ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spectrum Disorders
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