The anticonvulsant and neuroprotective effects of the Tanacetum Polycephalum hydroalcoholic extract against the experimental pentylenetetrazol‐induced model of the seizures in the male Wistar rats

2019 ◽  
Vol 7 (4) ◽  
pp. 186-192 ◽  
Author(s):  
Farzin Allahyari ◽  
Abdolkarim Hosseini ◽  
Vahid Azizi
Keyword(s):  
Wistar Rats ◽  
Neuroprotective Effects ◽  
Hydroalcoholic Extract ◽  
Male Wistar Rats

PARKINSONIA ACULEATA AS A POTENTIAL PHYTOTHERAPIC FACTOR IN THE INFLAMMATORY AND DYSLIPIDEMIC CONTROL OF WISTAR RATS

2021 ◽  
pp. 8
Author(s):  
◽  
◽  
◽  
Keyword(s):  
Inflammatory Cytokines ◽  
Wistar Rats ◽  
Serum Triglycerides ◽  
Hydroalcoholic Extract ◽  
Parkinsonia Aculeata ◽  
Commercial Diet ◽  
Aerial Parts ◽  
Westernized Diet ◽  
Male Wistar Rats ◽  
Pro Inflammatory Cytokines

Objective: The study evaluated the hypolipidemic and anti-inflammatory potential of the hydroalcoholic extract of P. Aculeata (HEPa/EtOAC) in Wistar rats fed with Westernized diet. Methods: The experiment was approved by the Ethics Committee (Federal University of Pernambuco-23076.027165 / 2010-21). The hydroalcoholic extract (HEPa/EtOAc) was obtained from the aerial parts of P. Aculeata and portioned by acetate/ethanol in different concentrations. 36 male Wistar rats were initially divided into two groups: Control (C, n = 6), fed a commercial diet (26g / 100g of protein; 63g / 100g of carbohydrates; 11g / 100g of lipids) and Westernized (W; n = 30) – fed an experimental diet (15g / 100g of protein; 51g / 100g of carbohydrates; 34 g/100g of lipids) receving water ad libitum. After 4 months of diet, W group was arbitrarily redistributed into six subgroups according to water supplementation, or different extracts concentrations: (n = 6 animals/group): W- distilled water (1mL/kg; po); WG – genfibrozil (140 mg/kg; p.o.); W35- 35 mg/kg; W70 – 70 mg /kg; p.o. and W140- 140 mg/kg; p.o for 30 days. The lipid profile and pro-inflammatory cytokines were analyzed. Results: The westernized diet caused dyslipidemia and the treatment with HEPa-EtOAc (140mg / kg), promoted a significant reduction in the concentration of pro-inflammatory cytokines, in total cholesterol, in the LDLc and serum triglycerides. Conclusion: The reduction of dyslipidemia and pro-inflammatory cytokines from the of P. Aculeata extract corroborate the ethnopharmacological potential of the plant, already used by the population for hypoglycemic purposes.

scholarly journals Protective Effect of Terminalia arjuna Against DBTC Induced Pancreatic Cancer in Male Wistar Rats

2021 ◽  
pp. 248-256
Author(s):  
Kadiyala Harshitha ◽  
Uma Sankar Gorla
Keyword(s):  
Pancreatic Cancer ◽  
Body Weight ◽  
Protective Effect ◽  
Wistar Rats ◽  
Negative Control ◽  
Terminalia Arjuna ◽  
Hydroalcoholic Extract ◽  
Group I ◽  
Male Wistar Rats ◽  
Per Oral

Aims: To study the protective effect of hydroalcoholic bark extract of Terminalia arjuna against DBTC induced pancreatic cancer in male wistar rats. Study design: Healthy male Wistar Albino rats weighing 150-200 g were segregated into four groups (n=6). Group I was considered as normal control, received normal saline (0.9%w/v, 1 ml/kg body weight, orally). Group II rats were treated with DBTC (6 mg/kg body weight, i.p.) which served as negative control. Group III and IV received Terminalia arjuna Linn bark hydroalcoholic extract at doses of 250 mg/kg body weight, per oral and 500 mg/kg body weight, per oral respectively. Place and Duration of Study: University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India, between May 2020 and July 2020. Methodology: The experimental animals were segregated into four groups of six rats each. According to acute toxicity data, 250 mg/kg as low dose and 500 mg/kg as high dose of the test compound have been chosen for administration. All the drugs were given for 28 consecutive days to all the respective groups with standard pellet diet and water ad libitum. The assessment of serum parameters such as α-Amylase, Lipase and blood glucose levels were carried out on 1st day, 14th day and 28th day to the respective groups. Results: Pretreated groups of Terminalia arjuna Linn bark hydroalcoholic extract (250 mg/kg and 500 mg/kg body weight, orally) showed significant (‘#’p<0.001) decrease in the levels of α-Amylase, Lipase and glucose in the blood when compared to DBTC (6 mg/kg body weight, i.p.) induced group which served as negative control. Conclusion: This study suggests that Terminalia arjuna may have a protective role against DBTC induced pancreatic cancer in male wistar rats and further investigation may be required to confirm its therapeutic potentials clinically.

scholarly journals Effect of Hydroalcoholic Extract ofCydonia oblongaMiller (Quince) on Sexual Behaviour of Wistar Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Muhammad Aslam ◽  
Ali Akbar Sial
Keyword(s):  
Body Weight ◽  
Single Dose ◽  
Sexual Behaviour ◽  
Wistar Rats ◽  
Sexually Active ◽  
Cydonia Oblonga ◽  
Hydroalcoholic Extract ◽  
Male Wistar Rats ◽  
Mating Performance ◽  
Remarkable Manner

Cydonia oblongaMiller (quince) is regarded as a potent libido invigorator in Tib-e-Nabvi and Unani System of Medicine. This study was carried out to evaluate the aphrodisiac activity of the hydroalcoholic extract of the fruits ofCydonia oblongaMiller (quince) in Wistar rats. The extract was administered orally by gavage in the dose of 500 mg/kg and 800 mg/kg body weight per day as a single dose for 28 days. The observed parameters were mounting frequency, assessment of mating performance, and orientation activities towards females, towards the environment, and towards self. The results showed that after administration of the extract mounting frequency and the mating performance of the rats increased highly significantlyP<0.01. The extract also influenced the behaviour of treated animals in comparison to nontreated rats in a remarkable manner, making them more attracted to females. These effects were observed in sexually active male Wistar rats.

scholarly journals Garcina Kola Neuroprotective effects on the Prefrontal Cortex Cyto-architecture of MDMA-induced Neuroinflammation in male Wistar Rats Model

2021 ◽  
pp. 100174
Author(s):  
John Afees Olanrewaju ◽  
Okoro Iheanyichukwu ◽  
Owolabi Joshua Oladele ◽  
Olatunji Sunday Yinka ◽  
Adelodun Stephen Taiye ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Wistar Rats ◽  
Neuroprotective Effects ◽  
Male Wistar Rats

Effects of 2600 MHz Radiofrequency Radiation in Brain Tissue of Male Wistar Rats and Neuroprotective Effects of Melatonin

2021 ◽  
Vol 42 (2) ◽  
pp. 159-172
Author(s):  
Kevser Delen ◽  
Bahriye Sırav ◽  
Sinem Oruç ◽  
Cemile M. Seymen ◽  
Dilek Kuzay ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Wistar Rats ◽  
Neuroprotective Effects ◽  
Radiofrequency Radiation ◽  
Male Wistar Rats

scholarly journals Neuroprotective Effect of Oxyresveratrol in Rotenone-Induced Parkinsonism Rats

2020 ◽  
Vol 15 (10) ◽  
pp. 1934578X2096619
Author(s):  
Ratchanee Rodsiri ◽  
Hattaya Benya-aphikul ◽  
Narudol Teerapattarakan ◽  
Oraphan Wanakhachornkrai ◽  
Weerawan Boonlert ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
Wistar Rats ◽  
Neuroprotective Effect ◽  
Antioxidant Properties ◽  
Motor Impairment ◽  
Polyphenolic Compound ◽  
Rotarod Test ◽  
Sod Activity ◽  
Neuroprotective Effects ◽  
Male Wistar Rats

Oxyresveratrol, a polyphenolic compound, has been reported as having antioxidant and anti-inflammatory effects. This study determined the neuroprotective effects of oxyresveratrol, extracted from the heartwood of Artocarpus lakoocha Roxburgh (Moraceae), on parkinsonism induced by rotenone. Male Wistar rats were divided into control, rotenone (PD), and rotenone plus oxyresveratrol (OXY) groups. The OXY rats received oxyresveratrol (300 mg/kg orally) on days 1-20. Rotenone (3 mg/kg subcutaneously) was given to PD and OXY rats on days 15, 16, 18, and 20. Motor function was determined by the rotarod test. Brains were collected to analyze dopaminergic neurons, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) and catalase activities. OXY rats exhibited a longer latency to fall than PD rats in the rotarod test ( P < 0.01) on day 16. The number of dopaminergic neurons in PD rats was lower than that in controls ( P < 0.01), while that of OXY rats was not different from controls. OXY rats showed a reduction in MDA levels ( P < 0.01) and increased catalase activity ( P < 0.05), while SOD activity was unaltered. The results suggest that oxyresveratrol pretreatment ameliorates motor impairment induced by rotenone and preserves dopaminergic neurons. The neuroprotective mechanism of oxyresveratrol is involved with its antioxidant properties.

scholarly journals Effect of the hydroalcoholic extract of pistachio on avoidance learning in male Wistar rats

2014 ◽  
Vol 3 (4) ◽  
pp. 180-187
Author(s):  
E Salari ◽  
M Baloochi ◽  
A Shamsizadeh ◽  
F Ayoobi ◽  
M Allahtavakoli ◽  
...  
Keyword(s):  
Avoidance Learning ◽  
Wistar Rats ◽  
Hydroalcoholic Extract ◽  
Male Wistar Rats

scholarly journals Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats

2019 ◽  
Vol 7 (9) ◽  
pp. 2875-2887
Author(s):  
Ali Parvin ◽  
Parichehreh Yaghmaei ◽  
Mehdi Noureddini ◽  
Sayyed Ali Haeri Roohani ◽  
Saeed Aminzadeh
Keyword(s):  
Wistar Rats ◽  
Hydroalcoholic Extract ◽  
Male Wistar Rats ◽  
Otostegia Persica
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