scholarly journals Lipid alterations in human frontal cortex in ALS‐FTLD‐TDP43 proteinopathy spectrum are partly related to peroxisome impairment

2020 ◽  
Author(s):  
Pol Andrés‐Benito ◽  
Ellen Gelpi ◽  
Mariona Jové ◽  
Natalia Mota‐Martorell ◽  
Èlia Obis ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Human Frontal Cortex

Characterization of dopamine receptor of type 4 (D4) in human frontal cortex post-mortem

2001 ◽  
Vol 11 ◽  
pp. S282-S283
Author(s):  
D. Marazziti ◽  
I. Masala ◽  
G. Giannaccini ◽  
E. Di Nasso ◽  
L. Betti ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Dopamine Receptor ◽  
Post Mortem ◽  
Human Frontal Cortex

Postnatal ontogeny of GTP binding protein in the human frontal cortex

Life Sciences ◽  
1999 ◽  
Vol 65 (22) ◽  
pp. 2315-2323 ◽  
Author(s):  
Hiroki Ozawa ◽  
Wataru Ukai ◽  
Johannes Kornhuber ◽  
Takafumi Yamaguchi ◽  
Lutz Froelich ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Binding Protein ◽  
Postnatal Ontogeny ◽  
Gtp Binding Protein ◽  
Gtp Binding ◽  
Human Frontal Cortex

scholarly journals A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ellis Patrick ◽  
Marta Olah ◽  
Mariko Taga ◽  
Hans-Ulrich Klein ◽  
Jishu Xu ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Frontal Cortex ◽  
Brain Aging ◽  
Immune Network ◽  
Tau Pathology ◽  
Cellular Mechanisms ◽  
Activated Microglia ◽  
Human Frontal Cortex ◽  
Β Amyloid ◽  
The Many

AbstractMicroglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer’s disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five modules of co-expressed genes related to microglia and assess their role in the neuropathologic features of AD in 540 subjects from two cohort studies of brain aging. Two of these transcriptional programs—modules 113 and 114—relate to the accumulation of β-amyloid, while module 5 relates to tau pathology. We replicate these associations in brain epigenomic data and in two independent datasets. In terms of tau, we propose that module 5, a marker of activated microglia, may lead to tau accumulation and subsequent cognitive decline. We validate our model further by showing that three representative module 5 genes (ACADVL, TRABD, and VASP) encode proteins that are upregulated in activated microglia in AD.

scholarly journals Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome

2018 ◽  
Vol 25 (12) ◽  
pp. 3267-3277 ◽  
Author(s):  
Stephen A. Semick ◽  
Leonardo Collado-Torres ◽  
Christina A. Markunas ◽  
Joo Heon Shin ◽  
Amy Deep-Soboslay ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Developmental Effects ◽  
Human Frontal Cortex ◽  
Maternal Smoking During Pregnancy

The adaptive human frontal cortex

Science ◽  
2020 ◽  
Vol 368 (6498) ◽  
pp. 1443.12-1445
Author(s):  
Peter Stern
Keyword(s):  
Frontal Cortex ◽  
Human Frontal Cortex

Changing plans: neural correlates of executive control in monkey and human frontal cortex

2006 ◽  
Vol 174 (2) ◽  
pp. 279-291 ◽  
Author(s):  
Elisa C. Dias ◽  
Tammy McGinnis ◽  
John F. Smiley ◽  
John J. Foxe ◽  
Charles E. Schroeder ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Executive Control ◽  
Neural Correlates ◽  
Human Frontal Cortex

Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain

2007 ◽  
Vol 292 (2) ◽  
pp. C795-C806 ◽  
Author(s):  
Robert D. Huber ◽  
Bo Gao ◽  
Marguerite-Anne Sidler Pfändler ◽  
Wenting Zhang-Fu ◽  
Simone Leuthold ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Human Brain ◽  
Frontal Cortex ◽  
Choroid Plexus ◽  
Splice Variants ◽  
Organic Anion ◽  
Xenopus Laevis Oocytes ◽  
Organic Anion Transporting Polypeptide ◽  
Human Frontal Cortex ◽  
Choroid Plexus Epithelial

In the present study we isolated two splice variants of organic anion transporting polypeptide 3A1 (OATP3A1_v1 and OATP3A1_v2) from human brain. OATP3A1_v2 lacks 18 amino acids (aa) at the COOH-terminal end (692 aa) but is otherwise similar in sequence to OATP3A1_v1 (710 aa). OATP3A1_v1 exhibits a wide tissue distribution, with expression in testis, various brain regions, heart, lung, spleen, peripheral blood leukocytes, and thyroid gland, whereas OATP3A1_v2 is predominantly expressed in testis and brain. On the cellular and subcellular levels OATP3A1_v1 could be immunolocalized in testicular germ cells, the basolateral plasma membrane of choroid plexus epithelial cells, and neuroglial cells of the gray matter of human frontal cortex. Immunolocalization of OATP3A1_v2 included Sertoli cells in testis, apical and/or subapical membranes in choroid plexus epithelial cells, and neurons (cell bodies and axons) of the gray and white matter of human frontal cortex. The rodent ortholog Oatp3a1 was also widely distributed in rat brain, and its localization included somatoneurons as well as astroglial cells. Transport studies in cRNA-injected Xenopus laevis oocytes and in stably transfected Chinese hamster ovary FlpIn cells revealed a similar broad substrate specificity for both splice variants. Transported substrates include prostaglandin (PG)E1 and PGE2, thyroxine, and the cyclic oligopeptides BQ-123 (endothelin receptor antagonist) and vasopressin. These studies provide further evidence for the involvement of OATPs in oligopeptide transport. They specifically suggest that OATP3A1 variants might be involved in the regulation of extracellular vasopressin concentration in human brain and thus might influence the neuromodulation of neurotransmission by cerebral neuropeptides such as vasopressin.

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