L‐DOPA regulates α‐synuclein accumulation in experimental parkinsonism

2020 ◽  
Author(s):  
Marc Deffains ◽  
Marie‐Hélène Canron ◽  
Margaux Teil ◽  
Qin Li ◽  
Benjamin Dehay ◽  
...  
Keyword(s):  
Experimental Parkinsonism

scholarly journals Correction: The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice

2021 ◽  
Vol 297 (1) ◽  
pp. 100864
Author(s):  
Niharika Amireddy ◽  
Srinivas N. Puttapaka ◽  
Ravali L. Vinnakota ◽  
Halley G. Ravuri ◽  
Swaroop Thonda ◽  
...  
Keyword(s):  
Mitochondrial Uncoupling ◽  
Experimental Parkinsonism

scholarly journals Subthalamic beta oscillations correlate with dopaminergic degeneration in experimental parkinsonism

2021 ◽  
Vol 335 ◽  
pp. 113513
Author(s):  
Jens K. Haumesser ◽  
Maximilian H. Beck ◽  
Franziska Pellegrini ◽  
Johanna Kühn ◽  
Wolf-Julian Neumann ◽  
...  
Keyword(s):  
Beta Oscillations ◽  
Experimental Parkinsonism ◽  
Dopaminergic Degeneration

Reversal of experimental parkinsonism by lesions of the subthalamic nucleus

Science ◽  
1990 ◽  
Vol 249 (4975) ◽  
pp. 1436-1438 ◽  
Author(s):  
H Bergman ◽  
T Wichmann ◽  
M. DeLong
Keyword(s):  
Subthalamic Nucleus ◽  
Experimental Parkinsonism

Dopamine-rich transplants in experimental parkinsonism

1983 ◽  
Vol 6 ◽  
pp. 266-270 ◽  
Author(s):  
Stephen B. Dunnett ◽  
Anders Björklund ◽  
Ulf Stenevi
Keyword(s):  
Experimental Parkinsonism

scholarly journals Bacopa monnieri Phytochemicals Mediated Synthesis of Platinum Nanoparticles and Its Neurorescue Effect on 1-Methyl 4-Phenyl 1,2,3,6 Tetrahydropyridine-Induced Experimental Parkinsonism in Zebrafish

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Jayshree Nellore ◽  
Cynthia Pauline ◽  
Kanchana Amarnath
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Platinum Nanoparticles ◽  
Complex I ◽  
Leaf Extract ◽  
Bacopa Monnieri ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Zebrafish Model ◽  
Experimental Parkinsonism

Current discovery demonstrates the rapid formation of platinum nanoparticles using leaf extract of a neurobeneficial plant, Bacopa monnieri (BmE). The nanoparticles (BmE-PtNPs) were stabilized and then coated with varied phytochemicals present within the leaf extract. These nanoparticles demonstrated the same activity of Complex I, as that of oxidizing NADH to NAD+ using a spectrophotometric method. This suggests that BmE-PtNPs are a potential medicinal substance for oxidative stress mediated disease with suppressed mitochondrial complex I, namely, Parkinson's disease (PD). Hence, the neuroprotective potentials of the phytochemical coated nanoparticle were explored in 1-methyl 4-phenyl 1,2,3,6 tetrahydropyridine- (MPTP-)induced experimental Parkinsonism in zebrafish model. BmE-PtNPs pretreatment significantly reversed toxic effects of MPTP by increasing the levels of dopamine, its metabolites, GSH and activities of GPx, catalase, SOD and complex I, and reducing levels of MDA along with enhanced locomotor activity. Taken together, these findings suggest that BmE-PtNPs have protective effect in MPTP-induced neurotoxicity in this model of Parkinson's disease via their dual functions as mitochondrial complex I and antioxidant activity.

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