scholarly journals Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory

2020 ◽  
Author(s):  
R. G. Valencia ◽  
E. Mihailovska ◽  
L. Winter ◽  
K. Bauer ◽  
I. Fischer ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Organelle Trafficking

Alleviation of pain and depression by specific neural transplants: Fine structural correlates

1992 ◽  
Vol 50 (2) ◽  
pp. 1066-1067
Author(s):  
George D. Pappas ◽  
Jacqueline Sagen
Keyword(s):  
Opioid Peptides ◽  
Chromaffin Cells ◽  
Pain Sensitivity ◽  
Opioid Peptide ◽  
Local Source ◽  
Pain Models ◽  
Neural Transplants ◽  
Adrenergic Antagonists ◽  
Csf Levels ◽  
Donor Source

We have been interested in the use of neural transplants mainly as a local source of neuroactive substances, rather than as a replacement for damaged neural circuities. In particular, we have been exploring the possibilities of reducing pain by transplants of opioid peptide producing cells, and reducing depression by transplants of monoamine-producing cells. For the past several years, work in our laboratory has demonstrated in both acute and chronic pain models that transplantation of adrenal medullary tissue or isolated chromaffin cells into CNS pain modulatory regions can reduce pain sensitivity in rodents. Chromaffin cells were chosen as donor source since they produce high levels of both opioid peptides and catecholamines, substances which independently, and probably synergistically, reduce pain sensitivity when injected locally into the spinal cord. The analgesia produced by these transplants most likely results from the release of both opioid peptides and catecholamines, since it can be blocked or attenuated by opiate or adrenergic antagonists, respectively. Furthermore, CSF levels of met-enkephalin and catecholamines are increased by the transplants.

Reduction in Pain Sensitivity from Pharmacological Elevation of Blood Pressure in Persons with Chronically Low Blood Pressure

2009 ◽  
Vol 23 (3) ◽  
pp. 104-112 ◽  
Author(s):  
Stefan Duschek ◽  
Heike Heiss ◽  
Boriana Buechner ◽  
Rainer Schandry
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Pain Sensitivity ◽  
Pain Threshold ◽  
Pain Perception ◽  
Drug Effects ◽  
Pressure Effects ◽  
Double Blind ◽  
Low Blood Pressure ◽  
Present Trial

Recent studies have revealed evidence for increased pain sensitivity in individuals with chronically low blood pressure. The present trial explored whether pain sensitivity can be reduced by pharmacological elevation of blood pressure. Effects of the sympathomimetic midodrine on threshold and tolerance to heat pain were examined in 52 hypotensive persons (mean blood pressure 96/61 mmHg) based on a randomized, placebo-controlled, double-blind design. Heat stimuli were applied to the forearm via a contact thermode. Confounding of drug effects on pain perception with changes in skin temperature, temperature sensitivity, and mood were statistically controlled for. Compared to placebo, higher pain threshold and tolerance, increased blood pressure, as well as reduced heart rate were observed under the sympathomimetic condition. Increases in systolic blood pressure between points of measurement correlated positively with increases in pain threshold and tolerance, and decreases in heart rate were associated with increases in pain threshold. The findings underline the causal role of hypotension in the augmented pain sensitivity related to this condition. Pain reduction as a function of heart rate decrease suggests involvement of a baroreceptor-related mechanism in the pain attrition. The increased proneness of persons with chronic hypotension toward clinical pain is discussed.

Gender Differences in Pain Sensitivity and Resting Blood Pressure

2010 ◽  
Author(s):  
Suzanne G. Helfer ◽  
Ashley D. Bugeja ◽  
Sarah E. Jackson ◽  
Elizabeth Woltja
Keyword(s):  
Blood Pressure ◽  
Gender Differences ◽  
Pain Sensitivity ◽  
Resting Blood Pressure

Pain Sensitivity Questionnaire--German Version

2009 ◽  
Author(s):  
Ruth Ruscheweyh ◽  
Martin Marziniak ◽  
Frederike Stumpenhorst ◽  
Julia Reinholz ◽  
Stefan Knecht
Keyword(s):  
Pain Sensitivity ◽  
German Version

Efficiency of 3% Non-epinephrine Mepivacaine Application During Intraligamentary Anesthesia With Positive and Negative Aspiration in Pain Sensitivity to Electric Current of Young Subject`s Upper Anterior Teeth Pulp:

2017 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Pain Sensitivity ◽  
Pain Threshold ◽  
Young Subject ◽  
Reference Level ◽  
Maximum Effect ◽  
Anterior Teeth ◽  
Randomized Controlled Studies ◽  
Group Methods ◽  
Peak Increase ◽  
Infiltration Anesthesia

Background: Separation methods of local anesthesia to diffuse and vascular must significantly affect the clinical effect of adrenaline containing local anesthetic (mepivacaine). The aim of this prospective, randomized, controlled studies µAde was to compare the degree of anesthesia of intact upper lateral incisor the cartridge ¼ 3% mepivacain without epinephrine in the group after the infiltration and after intraligamentary anesthesia (ILA) in the experimental group. Methods: Anesthesia performed computer syringe Sleeper One 86 subjects aged 20-23 years. In all cases, aspiration was performed. With pulp tester IVN-01 measured the pain threshold incisors and canines in microamperes during the anesthetic effect. Results: Reference level of all researched teeth (86 subjects) was ranged from 1 to 10 µA. Uniform pain threshold increase to 95 (±20) µA by 5 min. watched during infiltration anesthesia then this value gradually descended to reference level (by 20 min.). Peak single increase of pain threshold to 55 (±8,9) µA occurred immediately after 1st minute of ILA, then this value subsequently drops to reference level (10 µA) by 20 minutes. Difference between groups of infiltration and intraligamentary anesthesia (ILA+ red) and (ILA – green) presented on Chart 6. Conclusions: Infiltration anesthesia with mepivacaine without epinephrine smoothly diffusely increased the pain threshold of the front teeth, reaching a significant, maximum effect by 5 minutes. Intraligamentary injection immediately after administration created a peak increase in pain sensitivity at a lower level, almost without the participation of the diffuse component.

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