HCV RNA Genomic sequences and HCV-E2 glycoprotein in sural nerve biopsies from HCV-infected patients with peripheral neuropathy

2017 ◽  
Vol 44 (4) ◽  
pp. 427-438
Author(s):  
S. Russi ◽  
D. Sansonno ◽  
S. Monaco ◽  
S. Mariotto ◽  
S. Ferrari ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Sural Nerve ◽  
Genomic Sequences ◽  
Hcv Rna ◽  
E2 Glycoprotein ◽  
Hcv E2 Glycoprotein

HCV‐RNA In Sural Nerve From Hcv Infected Patients With Peripheral Neuropathy

2001 ◽  
Vol 6 (1) ◽  
pp. 46-47
Author(s):  
L De Martino ◽  
S Sampaolo ◽  
S Migliaresi ◽  
L Ambrosone ◽  
C Tucci ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Sural Nerve ◽  
Hcv Rna

scholarly journals High-resolution ultrasonography of the sural nerve in diabetic peripheral neuropathy

2020 ◽  
Vol 20 (81) ◽  
pp. e83-e89
Author(s):  
Kunwar Pal Singh ◽  
◽  
Kamlesh Gupta ◽  
Nilanshu Kataria ◽  
Vijinder Arora ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
High Resolution ◽  
Diabetic Peripheral Neuropathy ◽  
Sural Nerve ◽  
High Resolution Ultrasonography

Sialylation of HCV E2 Glycoprotein-Specific and Natural Anti-Glycan (TF, αGal) Antibodies as Signatures of Liver Damage

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Kurtenkov O ◽  
◽  
Jakovleva J ◽  
Sergejev B ◽  
Geller J ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
Liver Damage ◽  
Hepatic Damage ◽  
High Rate ◽  
Specific Antibodies ◽  
Non Invasive ◽  
E2 Glycoprotein ◽  
Invasive Evaluation ◽  
Hcv E2 Glycoprotein

The E2 glycoprotein is the target of broadly neutralizing antibodies against Hepatitis C Virus (HCV). There is evidence that the HCV E2-specific antibody glycosylation profile is associated with hepatic fibrosis progression. The main aim of this study was to compare the sialylation of E2-specific and naturally occurring antiglycan Abs to determine whether their combination could be beneficial for the non-invasive evaluation of hepatic damage. Fifty-eight patients with various stages of hepatic fibrosis or without were tested. The sialylation of HCV E2 glycoprotein-specific antibodies (E2-Abs), the Thomsen-Friedenreich antigen- and αGal glycotope-specific antibodies (TF-Abs, αGal-Abs) was analysed using the ELISA platform. The level of IgG Abs and their reactivity to Sialospecific Sambucus Nigra Lectin (SNA) were determined and changes in Abs sialylation were analysed based on the stage of liver fibrosis, HCV genotype and antiviral therapy efficacy. The late stage of liver Fibrosis (F4) was characterized by dramatically decreased E2-Ab SNA reactivity unlike stages with no fibrosis (P=0.003) and stages F1–F3 (P=0.0007). In contrast, antiglycan Abs showed an increased sialylation. In multiple regression analysis, the combination of E2 and TF-Abs sialylation patterns gave a significant advantage in assessing liver damage. A high rate of discrimination between F0 and F4 stages of fibrosis as well as between F1–F3 and F4 was obtained (ACC=0.948 and ACC=0.90, respectively). Thus, the combined analysis of disease-specific and natural Abs sialylation can remarkably enhance the clinical value of the approach in the non-invasive evaluation of hepatic damage.

scholarly journals A PRPH splice-donor variant associates with reduced sural nerve amplitude and risk of peripheral neuropathy

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Gyda Bjornsdottir ◽  
Erna V. Ivarsdottir ◽  
Kristbjorg Bjarnadottir ◽  
Stefania Benonisdottir ◽  
Sandra Sif Gylfadottir ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Sural Nerve ◽  
Splice Donor

Sural Nerve Blood Flow and Oxygenation is Increased in Painful Compared to Painless Diabetic Peripheral Neuropathy

2000 ◽  
Vol 98 (s42) ◽  
pp. 13P-13P
Author(s):  
SEM Eaton ◽  
S Ibrahim ◽  
ND Harris ◽  
F Selmi ◽  
KA Patel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Sural Nerve ◽  
Nerve Blood Flow

Molecular study and epitope mapping of the human antibody response against HCV/E2 glycoprotein by generation of monoclonal recombinant Fabs

2000 ◽  
Vol 118 (4) ◽  
pp. A1016
Author(s):  
Crsitiana Di Campli ◽  
Roberto Burioni ◽  
Francesca Bugli ◽  
Alessandra Desogus ◽  
Alessandro Vannini ◽  
...  
Keyword(s):  
Antibody Response ◽  
Epitope Mapping ◽  
Molecular Study ◽  
Human Antibody ◽  
E2 Glycoprotein ◽  
Hcv E2 Glycoprotein

scholarly journals Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis

1993 ◽  
Vol 120 (1) ◽  
pp. 60-63 ◽  
Author(s):  
Zachary Simmons ◽  
Mila Blaivas ◽  
Arnold J. Aguilera ◽  
Eva L. Feldman ◽  
Mark B. Bromberg ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Sural Nerve ◽  
Diagnostic Yield ◽  
Nerve Biopsy ◽  
Sural Nerve Biopsy ◽  
Primary Amyloidosis
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