Review: The role of vitamin D in nervous system health and disease

2013 ◽  
Vol 39 (5) ◽  
pp. 458-484 ◽  
Author(s):  
G. C. DeLuca ◽  
S. M. Kimball ◽  
J. Kolasinski ◽  
S. V. Ramagopalan ◽  
G. C. Ebers
Keyword(s):  
Vitamin D ◽  
Nervous System ◽  
Health And Disease

scholarly journals Role of 5-HT7 receptors in the immune system in health and disease

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
Alejandro Quintero-Villegas ◽  
Sergio Iván Valdés-Ferrer
Keyword(s):  
Central Nervous System ◽  
Immune Response ◽  
Nervous System ◽  
Immune System ◽  
Blood Platelets ◽  
Pain Tolerance ◽  
Immune Mediated ◽  
The Central Nervous System ◽  
Health And Disease

AbstractIn mammalians, serotonin (5-HT) has critical roles in the central nervous system (CNS), including mood stability, pain tolerance, or sleep patterns. However, the vast majority of serotonin is produced by intestinal enterochromaffin cells of the gastrointestinal tract and circulating blood platelets, also acting outside of the CNS. Serotonin effects are mediated through its interaction with 5-HT receptors (5-HTRs), a superfamily with a repertoire of at least fourteen well-characterized members. 5-HT7 receptors are the last 5-HTR member to be identified, with well-defined functions in the nervous, gastrointestinal, and vascular systems. The effects of serotonin on the immune response are less well understood. Mast cells are known to produce serotonin, while T cells, dendritic cells, monocytes, macrophages and microglia express 5-HT7 receptor. Here, we review the known roles of 5-HT7 receptors in the immune system, as well as their potential therapeutic implication in inflammatory and immune-mediated disorders.

The Role of the Sympathetic Nervous System in the Thymus in Health and Disease

2011 ◽  
Vol 18 (5) ◽  
pp. 339-349 ◽  
Author(s):  
Eduardo Roggero ◽  
Hugo O. Besedovsky ◽  
Adriana del Rey
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Health And Disease ◽  
Sympathetic Nervous

The Role of the Vitamin D Endocrine System in Health and Disease

1989 ◽  
Vol 320 (15) ◽  
pp. 980-991 ◽  
Author(s):  
Helmut Reichel ◽  
H. Phillip Koeffler ◽  
Anthony W. Norman
Keyword(s):  
Vitamin D ◽  
Endocrine System ◽  
Health And Disease

scholarly journals The Role of Vitamin D in Neurodegeneration and Other Pathological Processes of the Central Nervous System

2021 ◽  
Author(s):  
Carl Nikolaus Homann
Keyword(s):  
Central Nervous System ◽  
Vitamin D ◽  
Nervous System ◽  
Human Body ◽  
Serum Levels ◽  
Nerve Cells ◽  
Pivotal Role ◽  
The Central Nervous System ◽  
Measured Response

The nervous system is the most complex organ in the human body, and it is the most essential. However nerve cells are particularly precious as, only like muscle cells, once formed, they do not replicate. This means that neural injuries cannot easily be replaced or repaired. Vitamin D seems to play a pivotal role in protecting these vulnerable and most important structures, but exactly how and to what extend is still subject to debate. Systematically reviewing the vast body of research on the influence of Vitamin D in various neuropathological processes, we found that Vitamin D particularly plays a mitigating role in the development of chronic neurodegeneration and the measured response to acutely acquired traumatic and non-traumatic nerve cells incidents. Adequate serum levels of Vitamin D before the initiation of these processes is increasingly viewed as being neuroprotective. However, comprehensive data on using it as a treatment during the ongoing process or after the injury to neurons is completed are much more ambiguous. A recommendation for testing and supplementation of insufficiencies seems to be well-founded.

scholarly journals Role of TREK-1 in Health and Disease, Focus on the Central Nervous System

2019 ◽  
Vol 10 ◽  
Author(s):  
Alaeddine Djillani ◽  
Jean Mazella ◽  
Catherine Heurteaux ◽  
Marc Borsotto
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
The Central Nervous System ◽  
Health And Disease ◽  
Disease Focus

Role of glutamatergic neurotransmission in the enteric nervous system and brain-gut axis in health and disease

2016 ◽  
Vol 111 ◽  
pp. 14-33 ◽  
Author(s):  
Viviana Filpa ◽  
Elisabetta Moro ◽  
Marina Protasoni ◽  
Francesca Crema ◽  
Gianmario Frigo ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Glutamatergic Neurotransmission ◽  
Health And Disease

Regulatory role of NGFs in neurocognitive functions

2017 ◽  
Vol 28 (6) ◽  
pp. 649-673 ◽  
Author(s):  
Ashutosh Kumar ◽  
Vikas Pareek ◽  
Muneeb A. Faiq ◽  
Pavan Kumar ◽  
Khursheed Raza ◽  
...  
Keyword(s):  
Nervous System ◽  
Molecular Mechanisms ◽  
Adult Brain ◽  
Current Evidence ◽  
Future Research ◽  
Neurocognitive Dysfunction ◽  
Neurocognitive Functions ◽  
The Central Nervous System ◽  
Health And Disease

AbstractNerve growth factors (NGFs), especially the prototype NGF and brain-derived neurotrophic factor (BDNF), have a diverse array of functions in the central nervous system through their peculiar set of receptors and intricate signaling. They are implicated not only in the development of the nervous system but also in regulation of neurocognitive functions like learning, memory, synaptic transmission, and plasticity. Evidence even suggests their role in continued neurogenesis and experience-dependent neural network remodeling in adult brain. They have also been associated extensively with brain disorders characterized by neurocognitive dysfunction. In the present article, we aimed to make an exhaustive review of literature to get a comprehensive view on the role of NGFs in neurocognitive functions in health and disease. Starting with historical perspective, distribution in adult brain, implied molecular mechanisms, and developmental basis, this article further provides a detailed account of NGFs’ role in specified neurocognitive functions. Furthermore, it discusses plausible NGF-based homeostatic and adaptation mechanisms operating in the pathogenesis of neurocognitive disorders and has presents a survey of such disorders. Finally, it elaborates on current evidence and future possibilities in therapeutic applications of NGFs with an emphasis on recent research updates in drug delivery mechanisms. Conclusive remarks of the article make a strong case for plausible role of NGFs in comprehensive regulation of the neurocognitive functions and pathogenesis of related disorders and advocate that future research should be directed to explore use of NGF-based mechanisms in the prevention of implicated diseases as well as to target these molecules pharmacologically.

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