South Asian (Clade I) Candida auris Meningitis in a Pediatric Patient in Iran with a Review of the Literature

Mycoses ◽  
2021 ◽  
Author(s):  
Hossein Mirhendi ◽  
Arezou Charsizadeh ◽  
Shima Aboutalebian ◽  
Masoud Mohammadpour ◽  
Bahram Nikmanesh ◽  
...  
Keyword(s):  
Pediatric Patient ◽  
South Asian ◽  
Review Of The Literature ◽  
Candida Auris ◽  
Asian Clade

scholarly journals Two Candida auris Cases in Germany with No Recent Contact to Foreign Healthcare—Epidemiological and Microbiological Investigations

2021 ◽  
Vol 7 (5) ◽  
pp. 380
Author(s):  
Joerg Steinmann ◽  
Thomas Schrauzer ◽  
Lisa Kirchhoff ◽  
Jacques F. Meis ◽  
Peter-Michael Rath
Keyword(s):  
South Asian ◽  
Multidrug Resistant ◽  
Health Care Facilities ◽  
Candida Auris ◽  
Contact Precautions ◽  
Asian Clade ◽  
Care Facilities ◽  
Long Time ◽  
European Health ◽  
Healthcare Associated

Candida auris has become a global fungal public health threat. This multidrug-resistant yeast is associated with nosocomial intra- and interhospital transmissions causing healthcare-associated infections. Here, we report on two C. auris cases from Germany. The two patients stayed in Germany for a long time before C. auris was detected during their hospitalization. The patients were isolated in single rooms with contact precautions. No nosocomial transmissions were detected within the hospital. Both C. auris isolates exhibited high minimum inhibitory concentrations (MICs) of fluconazole and one isolate additionally high MICs against the echinocandins. Microsatellite genotyping showed that both strains belong to the South Asian clade. These two cases are examples for appropriate in-hospital care and infection control without further nosocomial spread. Awareness for this emerging, multidrug-resistant pathogen is justified and systematic surveillance in European health care facilities should be performed.

scholarly journals Regional spread of Candida auris

2021 ◽  
Vol 23 (2) ◽  
pp. 117-125
Author(s):  
Barantsevich N.E. ◽  
Levanova V.V. ◽  
Barantsevich Elena P.
Keyword(s):  
Great Britain ◽  
South Asian ◽  
Labor Migration ◽  
Preventive Measures ◽  
Time Schedule ◽  
Eastern Asia ◽  
Candida Auris ◽  
Asian Clade ◽  
The Usa ◽  
Rapid Dissemination

The geographical routes and time schedule of spread of C. auris – the fungus first identified in 2009 are discussed. Data on the increasing frequency of C. auris infections and rapid dissemination of the fungus from the regions of origin – southern Asia, eastern Asia, southern Africa and southern America – towards different regions of all continents except Antarctica, especially after 2016, are presented. Three different clades are encountered in Great Britain, all four clades – in the USA. South Asian clade is currently present in Russia: the introduction was associated with labor migration from Middle Asia. The necessity of C. auris surveillance, essential for the establishment of sources and routes of transmission and dissemination of different clades is emphasized. A window of possibilities is still present to prevent further spread of the fungus with the ability to cause outbreaks of hospital infections including intensive care departments. Rapid implementation of preventive measures during the pandemic of COVID-19 are needed taking into account introduction of fungus in new countries and clinics, as well as increased frequency of C. auris infections in some hospitals for patients infected with SARS-CoV-2 virus.

scholarly journals Comparison of In Vitro Killing Activity of Rezafungin, Anidulafungin, Caspofungin, and Micafungin against Four Candida auris Clades in RPMI-1640 in the Absence and Presence of Human Serum

2021 ◽  
Vol 9 (4) ◽  
pp. 863
Author(s):  
Renátó Kovács ◽  
Zoltán Tóth ◽  
Jeffrey B. Locke ◽  
Lajos Forgács ◽  
Gábor Kardos ◽  
...  
Keyword(s):  
South African ◽  
South Asian ◽  
Therapeutic Option ◽  
East Asian ◽  
Multidrug Resistant ◽  
South American ◽  
The South ◽  
Candida Auris ◽  
Asian Clade

Candida auris is an emerging and frequently multidrug-resistant pathogen against which the echinocandins are the preferred therapeutic option. We compared killing activities of anidulafungin, caspofungin, micafungin, and rezafungin against 13 isolates representing four C. auris clades (South Asian n = 3; East Asian n = 3; South African n = 3; South American n = 4, of which two were of environmental origin). Minimum inhibitory concentration MICs and killing kinetics in RPMI-1640 and RPMI-1640 plus 50% serum (50% serum) were determined. The four echinocandins were never fungicidal and induced large aggregates in RPMI-1640 and, less markedly, in 50% serum. Colony forming unit CFU decreases were found more consistently in 50% serum than in RPMI-1640. Isolates from the East Asian clade were killed at ≥1–≥ 4 mg/L with all echinocandins regardless of media. Anidulafungin and micafungin produced killing at peak drug serum concentration (8 mg/L) against environmental but not clinical isolates from the South American and the South African clades. Micafungin at ≥8 mg/L but not anidulafungin produced CFU decreases against the South Asian clade as well. In 50% serum, rezafungin at ≥1–≥ 8 mg/L produced killing against all four clades. The next generation echinocandin, rezafungin, showed the same or better activity at clinically attainable trough concentration regardless of media, compared with anidulafungin, caspofungin, and micafungin against all four tested C. auris clades.

scholarly journals Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit

2021 ◽  
Vol 7 (3) ◽  
pp. 220
Author(s):  
João N. de Almeida ◽  
Elaine C. Francisco ◽  
Ferry Hagen ◽  
Igor Brandão ◽  
Felicidade M. Pereira ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Antifungal Susceptibility ◽  
Candida Auris ◽  
Minimal Inhibitory Concentrations ◽  
First Case ◽  
Asian Clade ◽  
Travel Restrictions ◽  
Clade C ◽  
The City

In December 2020, Candida auris emerged in Brazil in the city of Salvador. The first two C. auris colonized patients were in the same COVID-19 intensive care unit. Antifungal susceptibility testing showed low minimal inhibitory concentrations of 1 µg/mL, 2 µg/mL, 0.03 µg/L, and 0.06 µg/mL for amphotericin B, fluconazole, voriconazole, and anidulafungin, respectively. Microsatellite typing revealed that the strains are clonal and belong to the South Asian clade C. auris. The travel restrictions during the COVID-19 pandemic and the absence of travel history among the colonized patients lead to the hypothesis that this species was introduced several months before the recognition of the first case and/or emerged locally in the coastline Salvador area.

scholarly journals Vemurafenib in Langerhans cell histiocytosis: report of a pediatric patient and review of the literature

Oncotarget ◽  
2018 ◽  
Vol 9 (31) ◽  
pp. 22236-22240 ◽  
Author(s):  
Anne Heisig ◽  
Jan Sörensen ◽  
Stefanie-Yvonne Zimmermann ◽  
Stefan Schöning ◽  
Dirk Schwabe ◽  
...  
Keyword(s):  
Pediatric Patient ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Review Of The Literature

scholarly journals Ecthyma Gangrenosum in a Pediatric Patient and Review of the Literature

2016 ◽  
Vol 3 (4) ◽  
pp. 200
Author(s):  
Sevgi Buyukbese Sarsu ◽  
Mehmet Ergun Parmaksız ◽  
Ayhan Yaman
Keyword(s):  
Pediatric Patient ◽  
Review Of The Literature ◽  
Ecthyma Gangrenosum

Whole genome sequence of first Candida auris strain, isolated in Russia

2019 ◽  
Vol 58 (3) ◽  
pp. 414-416 ◽  
Author(s):  
Ivan M Pchelin ◽  
Daniil V Azarov ◽  
Maria A Churina ◽  
Igor A Ryabinin ◽  
Irina V Vibornova ◽  
...  
Keyword(s):  
South Asian ◽  
Genome Sequence ◽  
Draft Genome ◽  
Multidrug Resistant ◽  
Whole Genome Sequence ◽  
Candida Auris ◽  
Fluconazole Resistance ◽  
Russian Strain ◽  
Resistant Strains ◽  
Original Species

Abstract Candida auris is an emergent yeast pathogen, easily transmissible between patients and with high percent of multidrug resistant strains. Here we present a draft genome sequence of the first known Russian strain of C. auris, isolated from a case of candidemia. The strain clustered within South Asian C. auris clade and seemingly represented an independent event of dissemination from the original species range. Observed fluconazole resistance was probably due to F105L and K143R mutations in ERG11.

scholarly journals Insights into the Unique Nature of the East Asian Clade of the Emerging Pathogenic Yeast Candida auris

2019 ◽  
Vol 57 (4) ◽  
Author(s):  
Rory M. Welsh ◽  
D. Joseph Sexton ◽  
Kaitlin Forsberg ◽  
Snigdha Vallabhaneni ◽  
Anastasia Litvintseva
Keyword(s):  
Large Scale ◽  
East Asian ◽  
Candida Auris ◽  
Pathogenic Yeast ◽  
Content Type ◽  
New Information ◽  
Asian Clade ◽  
Single Region ◽  
Invasive Infections ◽  
Unique Nature

ABSTRACT The emerging yeast Candida auris can be highly drug resistant, causing invasive infections, and large outbreaks. C. auris went from an unknown pathogen a decade ago to being reported in over thirty countries on six continents. C. auris consists of four discrete clades, based on where the first isolates of the clade were reported, South Asian (clade I), East Asian (clade II), African (clade III), and South American (clade IV). These clades have unique genetic and biochemical characteristics that are important to understand and inform the global response to C. auris. Clade II has been underrepresented in the literature despite being the first one discovered. In this issue of the Journal of Clinical Microbiology, Y. J. Kwon et al. (J Clin Microbiol 57:e01624-18, 2019, https://doi.org/10.1128/JCM.01624-18) describe the largest collection of clinical isolates from Clade II, which is also the longest-running span of clinical cases, 20 years, from any single region to date. Clade II appears to have a propensity for the ear that is uncharacteristic of the other clades, which typically cause invasive infections and large-scale outbreaks. This study provides new information on an understudied lineage of C. auris and has important implications for future surveillance.

HydroCoil embolization of a ruptured infectious aneurysm in a pediatric patient: case report and review of the literature

2006 ◽  
Vol 23 (6) ◽  
pp. 707-712 ◽  
Author(s):  
Christopher Eddleman ◽  
Dimitrios Nikas ◽  
Ali Shaibani ◽  
Pervez Khan ◽  
Arthur J. DiPatri ◽  
...  
Keyword(s):  
Case Report ◽  
Pediatric Patient ◽  
Review Of The Literature ◽  
Patient Case ◽  
Infectious Aneurysm

scholarly journals NSRG-01. PRIMARY GLIOBLASTOMA IN THE PINEAL REGION OF A PEDIATRIC PATIENT: A CASE REPORT AND REVIEW OF THE LITERATURE

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i145-i146
Author(s):  
Lee Hwang ◽  
Gabrielle Yeaney ◽  
Tanya Tekautz ◽  
Kaine Onwuzulike ◽  
Violette Recinos
Keyword(s):  
Case Report ◽  
Pediatric Patient ◽  
Pineal Region ◽  
Review Of The Literature ◽  
Primary Glioblastoma
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