Majocchi’s granuloma: autoinoculation and adaption of Trichophyton rubrum with molecular evidence

Mycoses ◽  
2021 ◽  
Author(s):  
Ying Zhao ◽  
Mingyu Gan ◽  
Li Li ◽  
Huilin Su ◽  
Qiangqiang Zhang ◽  
...  
Keyword(s):  
Trichophyton Rubrum ◽  
Molecular Evidence ◽  
Majocchi’S Granuloma

Tinea corporis due to Trichophyton rubrum in a Woman and Tinea capitis in her 15-Day-Old Baby: Molecular Evidence of Vertical Transmission

2011 ◽  
Vol 173 (2-3) ◽  
pp. 135-138 ◽  
Author(s):  
E. T. M. Mapelli ◽  
E. Borghi ◽  
A. Cerri ◽  
R. Sciota ◽  
G. Morace ◽  
...  
Keyword(s):  
Vertical Transmission ◽  
Tinea Capitis ◽  
Trichophyton Rubrum ◽  
Tinea Corporis ◽  
Molecular Evidence

scholarly journals Majocchi's granuloma of the vulva: A case report

2020 ◽  
Vol 49 (4) ◽  
pp. 47-52
Author(s):  
Milan Bjekić ◽  
Danijela Pecarski
Keyword(s):  
Case Report ◽  
Potassium Hydroxide ◽  
Trichophyton Rubrum ◽  
Subcutaneous Tissue ◽  
Hair Follicles ◽  
Glucose Agar ◽  
Nodular Lesions ◽  
Sabouraud Glucose Agar ◽  
Majocchi’S Granuloma ◽  
Immunocompromised Hosts

Introduction/Aim: Majocchi's granuloma is an infrequent deep-seated fungal infection where pathogen invades hair follicles, entering the dermal and subcutaneous tissue, thus forming granulomatous dermal and/or hypodermal changes. There are two clinical types: the first one is common in healthy individuals characterized by superficial perifollicular papular infection, and the second is followed by the deep subcutaneous nodules usually reported among immunocompromised hosts. This infection is usually caused by Trichophyton rubrum. The aim of this paper is to show the rare localization of this disease in the area of the vulva. Case report: We present a 20-year-old immunocompetent woman with multiple papules, nodules, and pustules on the hairy part of the vulva. Potassium hydroxide preparations of skin scrapings were negative and culture performed on Sabouraud glucose agar revealed Trichophyton rubrum. The patient was treated with the oral systemic antifungal therapy for four weeks and all lesions resolved. Conclusion: Majocchi's granuloma should not be overlooked in patients with papular and nodular lesions in the vulvar region.

scholarly journals Majocchi’s Granuloma on the Forearm Caused by Trichophyton tonsurans in an Immunocompetent Patient

2020 ◽  
Author(s):  
Yun-yan Zheng ◽  
Yue Li ◽  
Ming-yan Chen ◽  
Qian-yun Mei ◽  
Ru-zhi Zhang
Keyword(s):  
Trichophyton Rubrum ◽  
Subcutaneous Tissue ◽  
Immunocompetent Patient ◽  
Lower Limbs ◽  
Trichophyton Tonsurans ◽  
Anterior Aspect ◽  
Majocchi’S Granuloma ◽  
Mycological Examination ◽  
Dermal Infiltrate ◽  
A Site

Abstract Majocchi's granuloma is an uncommon fungal infection of the dermis and subcutaneous tissue. The most frequently identified cause of Majocchi’s granuloma is anthropophilic Trichophyton rubrum, and it is most commonly located on the anterior aspect of the lower limbs in women. Here, we report a case of Majocchi’s granuloma on the forearm, a site that is rarely involved, in a 62-year-old woman who had been bitten by a dog. Histological examination revealed a dense dermal infiltrate composed of lymphoplasmacytic cells and neutrophils, with hyphae in the dermis. The presence of the fungus, Trichophyton tonsurans, was confirmed by mycological examination. Therefore, histological and mycological examination conformed the diagnosis of Majocchi’s granuloma. The patient was treated with local moxibustion and itraconazole, 200 mg/day, for 60 days, which facilitated a complete resolution of the lesions

scholarly journals Majocchi's granuloma caused by Trichophyton rubrum after facial injection with hyaluronic acid: A case report

2020 ◽  
Vol 8 (17) ◽  
pp. 3853-3858
Author(s):  
Jie Liu ◽  
Wen-Qiang Xin ◽  
Lan-Ting Liu ◽  
Chao-Feng Chen ◽  
Lin Wu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Case Report ◽  
Trichophyton Rubrum ◽  
Majocchi’S Granuloma

Trichophyton rubrum Infection Characterized by Majocchi’s Granuloma and Deeper Dermatophytosis: Case Report and Review of Published Literature

2016 ◽  
Vol 182 (5-6) ◽  
pp. 549-554 ◽  
Author(s):  
Huilin Su ◽  
Li Li ◽  
Benlin Cheng ◽  
Junhao Zhu ◽  
Qiangqiang Zhang ◽  
...  
Keyword(s):  
Case Report ◽  
Trichophyton Rubrum ◽  
Majocchi’S Granuloma

scholarly journals Majocchi's Granuloma of the Knee Caused by Trichophyton rubrum Presented as Tinea Incognito

2017 ◽  
Vol 22 (3) ◽  
pp. 122-128
Author(s):  
박민우 ◽  
최종수 ◽  
Ha,Kyung-Im ◽  
이종임 ◽  
서무규 ◽  
...  
Keyword(s):  
Trichophyton Rubrum ◽  
Tinea Incognito ◽  
Majocchi’S Granuloma

scholarly journals Majocchi’s Granuloma in a Healthy Adult Man – a Case Report

2015 ◽  
Vol 7 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Milan Bjekić ◽  
Jasna Gajica Basara
Keyword(s):  
World Literature ◽  
Trichophyton Rubrum ◽  
Topical Steroid ◽  
Skin Lesions ◽  
Hair Follicles ◽  
Fungal Culture ◽  
Direct Microscopy ◽  
Topical Corticosteroids ◽  
Tinea Incognito ◽  
Majocchi’S Granuloma

Abstract Majocchi’s granuloma was first described by Domenico Majocchi in 1883, as a deep chronic dermatophyte infection of hair follicles, in which dermatophytes penetrate the dermis through hair canals, forming granulomatous changes in the dermis and/or hypodermis. Majocchi’s granuloma has two different clinical variants: the first is a small perifollicular papular type, seen in otherwise healthy individuals, that occurs secondary to trauma (e.g. in women with chronic tinea pedis that extends to the legs and who shave their legs); the second is a type with deep plaques or nodular lesions in immunocompromised hosts. The diagnosis is primarily made using direct microscopy of unstained specimens and fungal cultures, while additional diagnostics (histology, PCR) are generally not necessary. It is most commonly caused by Trichophyton rubrum. We present a 26-year-old otherwise healthy man exhibiting blue erythematous patches over the skin of his abdomen on clinical examination, which agglomerated to form slightly raised plaques with irregular ovoid contours, spreading from umbilicus to the pubic region; they were covered with multiple red-blue, erythematous partly coalescing scales, eroded, firm papules and nodules. On pressure, some nodules excreted viscid and turbid sero-purulent content. The lesions were slightly itchy. The patient was previously unsuccessfully treated during at least 4 weeks with a topical steroid cream prescribed by his physician. Direct microscopy for fungi of skin scrapings and pus mounted in potassium hydroxide was negative. Cultures of the contents and scrapings were performed on Sabouraud’s glucose agar and Trichophyton rubrum was isolated. The diagnosis of Majocchi’s granuloma was made, and the patient was treated with itraconazole (200 mg daily) for eight weeks, when all lesions resolved and fungal culture was negative. Misapplication of topical corticosteroids over a long period, as in our case, can produce Majocchi’s granuloma. When assessing skin lesions of unusual appearance, especially if aggravated by corticosteroids, dermatologists and general practitioners should consider tinea incognito, which may appear in its invasive form of Majocchi’s granuloma. The available world literature shows that Majocchi’s granuloma presenting as tinea incognito caused by topical corticosteroids has been reported extremely rarely.

scholarly journals Majocchi’s Granuloma on the Forearm Caused by Trichophyton tonsurans in an Immunocompetent Patient

2020 ◽  
Author(s):  
Yun-yan Zheng ◽  
Yue Li ◽  
Ming-yan Chen ◽  
Qian-yun Mei ◽  
Ru-zhi Zhang
Keyword(s):  
Fungal Infection ◽  
Trichophyton Rubrum ◽  
Immunocompetent Patient ◽  
Complete Regression ◽  
Trichophyton Tonsurans ◽  
Anterior Aspect ◽  
Majocchi’S Granuloma ◽  
Mycological Examination ◽  
Dermal Infiltrate ◽  
A Site

Abstract Majocchi’s granuloma is a rare fungal infection of the dermis. The most frequently identified cause of Majocchi’s granuloma is anthropophilic Trichophyton rubrum , and it is frequently seen on the anterior aspect of the legs of women. Here, we report a case of Majocchi’s granuloma on the forearm, a site that is rarely involved, in a 62-year-old woman who had been bitten by a dog. Histological examination revealed hyphae in the dermis with a diffuse dermal infiltrate consisting of lymphoplasmacytic cells and neutrophils. Mycological examination confirmed the presence of the fungus, Trichophyton rubrum. Therefore, the diagnosis of Majocchi’s granuloma was confirmed by histological and mycological examination. The patient was treated with local moxibustion and itraconazole, 200 mg/day, for 60 days, which promoted a complete regression of the lesions.

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