In vitro detection of Candida and Aspergillus antigen in parenteral nutrition and fixed combinations of piperacillin‐tazobactam

Mycoses ◽  
2018 ◽  
Vol 61 (12) ◽  
pp. 931-937 ◽  
Author(s):  
Wencke Walter ◽  
Martin Bornhäuser ◽  
Friedrich Stölzel ◽  
Anne Zeidler ◽  
Holger Knoth
Keyword(s):  
Parenteral Nutrition ◽  
Aspergillus Antigen

scholarly journals Co-Administration of Drugs and Parenteral Nutrition: In Vitro Compatibility Studies of Loop Diuretics for Safer Clinical Practice

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1092
Author(s):  
Szymon Tomczak ◽  
Maciej Stawny ◽  
Anna Jelińska
Keyword(s):  
Clinical Practice ◽  
Zeta Potential ◽  
Parenteral Nutrition ◽  
Lipid Emulsion ◽  
Droplet Diameter ◽  
Loop Diuretics ◽  
Compatibility Studies ◽  
Emulsion Droplet ◽  
Flow Rates

Parenteral nutrition (PN) admixtures are prone to interacting with drugs administered intravenously via a common catheter. This may cause a threat to a patient’s health and life. The literature that has been reported on the compatibility of loop diuretics with PN presents conflicting results. This work aimed to study the compatibility of furosemide and torsemide with PN used in clinical practice. Undiluted solutions of drugs were mixed with PN at various ratios determined by flow rates. In order to assess compatibility, visual control was followed by pH measurement, osmolality, mean emulsion droplet diameter (MDD), and zeta potential upon mixing and at 4 h of storage. No macroscopic changes that indicated lipid emulsion degradation were observed. After the addition of the drugs, the value of pH ranged from 6.37 ± 0.01 to 7.38 ± 0.01. The zeta potential was in reverse proportion to the drug concentration. The addition of the drugs did not affect the MDD. It may be suggested that the co-administration of furosemide or torsemide and PN caused no interaction. The absence of such signs of unwanted interactions allowed for the co-administration of the mentioned loop diuretics and PN at each of the studied ratios.

Admixture of a Multivitamin Preparation to Parenteral Nutrition: The Major Contributor to In Vitro Generation of Peroxides

PEDIATRICS ◽  
1997 ◽  
Vol 99 (3) ◽  
pp. e6-e6 ◽  
Author(s):  
J.-C. Lavoie ◽  
S. Belanger ◽  
M. Spalinger ◽  
P. Chessex
Keyword(s):  
Parenteral Nutrition ◽  
Major Contributor ◽  
Multivitamin Preparation

Coagulation Studies after Administration of a Fat Emulsion, Intralipid®

1967 ◽  
Vol 18 (03/04) ◽  
pp. 664-669 ◽  
Author(s):  
S Cronberg ◽  
Inga Marie Nilsson
Keyword(s):  
Parenteral Nutrition ◽  
Whole Blood ◽  
Clinical Relevance ◽  
Bleeding Time ◽  
Fibrinolytic System ◽  
Platelet Adhesiveness ◽  
Single Infusion ◽  
Fat Emulsion ◽  
Prolonged Bleeding Time

SummaryA single infusion of a fat emulsion, Intralipid®, used for parenteral nutrition was given to 11 healthy normals, 3 patients with von Willebrand’s disease and 3 with mild or moderately severe thrombasthenia. The infusion had no effect on coagulation or the fibrinolytic system. Platelet adhesiveness, as determined with Hellem’s whole blood method, was markedly increased but not with his plasma-ADP method or with Salzman’s method. No shortening of the bleeding time was observed in the normals or in the patients with prolonged bleeding time. The change observed in platelet adhesiveness is therefore believed to be an in vitro artefact with no clinical relevance.

In Vitro Assessment of Interaction Between Amino Acids and Copper in Neonatal Parenteral Nutrition

2016 ◽  
Vol 40 (6) ◽  
pp. 827-834 ◽  
Author(s):  
Aurélie Foinard ◽  
Maxime Perez ◽  
Christine Barthélémy ◽  
Damien Lannoy ◽  
Florence Flamein ◽  
...  
Keyword(s):  
Amino Acids ◽  
Parenteral Nutrition ◽  
In Vitro Assessment

scholarly journals Toward Safe Pharmacotherapy: The Interplay between Meropenem and Parenteral Nutrition Admixtures

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 217
Author(s):  
Aleksandra Gostyńska ◽  
Ludwika Piwowarczyk ◽  
Malwina Nadolna ◽  
Anna Jelińska ◽  
Katarzyna Dettlaff ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Parenteral Nutrition ◽  
Lipid Droplets ◽  
Droplet Diameter ◽  
Clinical Problem ◽  
Intravenous Antibiotics ◽  
Lipid Droplet Size ◽  
The Mean ◽  
Common Clinical Problem

Simultaneous administration of parenteral nutrition (PN) admixtures with intravenous antibiotics is a common clinical problem. Coadministration of drugs incompatible with PN admixture may affect its stability, especially in the context of lipid droplet size, which is a crucial parameter for patient safety. In the present study, we investigate the in vitro compatibility of meropenem (Meropenem 1000, MPM) with five commercial PN admixtures used worldwide: Kabiven, Olimel N9E, Nutriflex Lipid Special, Nutriflex Omega Special, and SmofKabiven. The appropriate volumetric ratios, reflecting their clinical practice ratios, were used to prepare the MPM–PN admixture samples. Physicochemical properties of MPM–PN admixtures samples were determined upon preparation and after four hours of storage. The pH changes for all MPM–PN admixtures samples did not exceed the assumed level of acceptability and ranged from 6.41 to 7.42. After four hours of storage, the osmolarity changes were ±3%, except MPM–Olimel N9E samples, for which differences from 7% to 11% were observed. The adopted level of acceptability of changes in zeta potential after four hours of storage (±3 mV) was met for MPM–Kabiven, MPM–Nutriflex Lipid Special, and MPM–Nutriflex Omega Special. The mean droplet diameter for all samples was below 500 nm. However, only in the case of Nutriflex Lipid Special and Nutriflex Omega Special, the addition of MPM did not cause the formation of the second fraction of lipid droplets. The coadministration of MPM via Y-site with Kabiven, Olimel N9E, and Smofkabiven should be avoided due to osmolarity fluctuations (MPM–Olimel), significant differences in zeta potential (MPM–Olimel, MPM–Smofkabiven), and the presence of the second fraction of lipid droplets >1000 nm (MPM–Kabiven, MPM–Olimel, and MPM–Smofkabiven). The assumed acceptance criteria for MPM compatibility of MPM with PN admixtures were met only for Nutriflex Lipid Special and Nutriflex Omega Special in 1:1, 2:1, and 4:1 volume ratios.

scholarly journals Aminophylline Compatibility with Neonatal Total Parenteral Nutrition

2008 ◽  
Vol 13 (2) ◽  
pp. 76-79
Author(s):  
Rachel Sykes ◽  
Christopher McPherson ◽  
Kristi Foulks ◽  
Joni Wade ◽  
Peter Gal
Keyword(s):  
Renal Failure ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Preterm Infants ◽  
Glass Vial ◽  
Minute Interval

OBJECTIVES Aminophylline has proven useful for treating renal failure in preterm infants. Previous reports state that aminophylline is incompatible with some neonatal total parenteral nutrition (TPN) solutions. If this is correct, administration of aminophylline doses would be complicated by the need to hold TPN and provide flush solution after each aminophylline dose. Our experience with administering aminophylline over 30 minutes concurrently with TPN was that this was not problematic. We therefore examined the in vitro compatibility of aminophylline and TPN solutions used in our neonates over a 30-minute interval to see if our policy of allowing concurrent mixing of these products was appropriate. METHODS TPN solutions (2.5 mL) were mixed with 1 mL of intravenous aminophylline 2.5 mg/mL in a glass vial. Three different TPN solutions used in our NICU were collected for the study, and five samples of each combination were prepared. Samples were watched for 60 minutes to see if precipitation occurred. RESULTS Although the aminophylline and TPN solutions were not miscible, no turbidity or precipitation was observed. CONCLUSIONS This study supports that aminophylline is physically compatible with neonatal TPN for 60 minutes.

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