scholarly journals Two Phytophthora parasitica cysteine protease genes, PpCys44 and PpCys45 , trigger cell death in various Nicotiana spp. and act as virulence factors

2020 ◽  
Vol 21 (4) ◽  
pp. 541-554 ◽  
Author(s):  
Qiang Zhang ◽  
Weiwei Li ◽  
Jiapeng Yang ◽  
Junjie Xu ◽  
Yuling Meng ◽  
...  
Keyword(s):  
Cell Death ◽  
Virulence Factors ◽  
Cysteine Protease ◽  
Phytophthora Parasitica ◽  
Trigger Cell Death

Inhibition of Autophagy Potentiated Hippocampal Cell Death Induced by Endoplasmic Reticulum Stress and its Activation by Trehalose Failed to be Neuroprotective

2019 ◽  
Vol 16 (1) ◽  
pp. 3-11
Author(s):  
Luisa Halbe ◽  
Abdelhaq Rami
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Er Stress ◽  
Cell Damage ◽  
Protective Mechanism ◽  
Unfolded Proteins ◽  
Neuronal Viability ◽  
Hippocampal Cell ◽  
Trigger Cell Death ◽  
Autophagy Inhibition

Introduction: Endoplasmic reticulum (ER) stress induced the mobilization of two protein breakdown routes, the proteasomal- and autophagy-associated degradation. During ERassociated degradation, unfolded ER proteins are translocated to the cytosol where they are cleaved by the proteasome. When the accumulation of misfolded or unfolded proteins excels the ER capacity, autophagy can be activated in order to undertake the degradative machinery and to attenuate the ER stress. Autophagy is a mechanism by which macromolecules and defective organelles are included in autophagosomes and delivered to lysosomes for degradation and recycling of bioenergetics substrate. Materials and Methods: Autophagy upon ER stress serves initially as a protective mechanism, however when the stress is more pronounced the autophagic response will trigger cell death. Because autophagy could function as a double edged sword in cell viability, we examined the effects autophagy modulation on ER stress-induced cell death in HT22 murine hippocampal neuronal cells. We investigated the effects of both autophagy-inhibition by 3-methyladenine (3-MA) and autophagy-activation by trehalose on ER-stress induced damage in hippocampal HT22 neurons. We evaluated the expression of ER stress- and autophagy-sensors as well as the neuronal viability. Results and Conclusion: Based on our findings, we conclude that under ER-stress conditions, inhibition of autophagy exacerbates cell damage and induction of autophagy by trehalose failed to be neuroprotective.

scholarly journals The Cysteine Protease CEP1, a Key Executor Involved in Tapetal Programmed Cell Death, Regulates Pollen Development in Arabidopsis

2014 ◽  
Vol 26 (7) ◽  
pp. 2939-2961 ◽  
Author(s):  
Dandan Zhang ◽  
Di Liu ◽  
Xiaomeng Lv ◽  
Ying Wang ◽  
Zhili Xun ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Cysteine Protease ◽  
Pollen Development

scholarly journals Short-term intense Bcr–Abl kinase inhibition with nilotinib is adequate to trigger cell death in BCR-ABL+ cells

Leukemia ◽  
2009 ◽  
Vol 23 (6) ◽  
pp. 1205-1206 ◽  
Author(s):  
D K Hiwase ◽  
D L White ◽  
V A Saunders ◽  
S Kumar ◽  
J V Melo ◽  
...  
Keyword(s):  
Cell Death ◽  
Short Term ◽  
Kinase Inhibition ◽  
Abl Kinase ◽  
Trigger Cell Death

Stilbene–Chalcone Hybrids: Design, Synthesis, and Evaluation as a New Class of Antimalarial Scaffolds That Trigger Cell Death through Stage Specific Apoptosis

2011 ◽  
Vol 55 (1) ◽  
pp. 297-311 ◽  
Author(s):  
Naina Sharma ◽  
Dinesh Mohanakrishnan ◽  
Amit Shard ◽  
Abhishek Sharma ◽  
Saima ◽  
...  
Keyword(s):  
Cell Death ◽  
Design Synthesis ◽  
New Class ◽  
Trigger Cell Death

PPE11 of Mycobacterium tuberculosis can alter host inflammatory response and trigger cell death

2019 ◽  
Vol 126 ◽  
pp. 45-55 ◽  
Author(s):  
Xuan Peng ◽  
Tao Luo ◽  
Xiaoqian Zhai ◽  
Chunxi Zhang ◽  
Jing Suo ◽  
...  
Keyword(s):  
Cell Death ◽  
Mycobacterium Tuberculosis ◽  
Inflammatory Response ◽  
Trigger Cell Death ◽  
Host Inflammatory Response

scholarly journals ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

2017 ◽  
Vol 214 (8) ◽  
pp. 2217-2229 ◽  
Author(s):  
Sannula Kesavardhana ◽  
Teneema Kuriakose ◽  
Clifford S. Guy ◽  
Parimal Samir ◽  
R.K. Subbarao Malireddi ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Posttranslational Modifications ◽  
Influenza A ◽  
Influenza Virus Infection ◽  
Dna Binding Protein ◽  
Cell Death Pathways ◽  
Signaling Axis ◽  
Trigger Cell Death ◽  
Inducible Gene

Innate sensing of influenza virus infection induces activation of programmed cell death pathways. We have recently identified Z-DNA–binding protein 1 (ZBP1) as an innate sensor of influenza A virus (IAV). ZBP1-mediated IAV sensing is critical for triggering programmed cell death in the infected lungs. Surprisingly, little is known about the mechanisms regulating ZBP1 activation to induce programmed cell death. Here, we report that the sensing of IAV RNA by retinoic acid inducible gene I (RIG-I) initiates ZBP1-mediated cell death via the RIG-I–MAVS–IFN-β signaling axis. IAV infection induces ubiquitination of ZBP1, suggesting potential regulation of ZBP1 function through posttranslational modifications. We further demonstrate that ZBP1 senses viral ribonucleoprotein (vRNP) complexes of IAV to trigger cell death. These findings collectively indicate that ZBP1 activation requires RIG-I signaling, ubiquitination, and vRNP sensing to trigger activation of programmed cell death pathways during IAV infection. The mechanism of ZBP1 activation described here may have broader implications in the context of virus-induced cell death.

scholarly journals Plant-induced cell death in the oomycete pathogen Phytophthora parasitica

2005 ◽  
Vol 7 (9) ◽  
pp. 1365-1378 ◽  
Author(s):  
Eric Galiana ◽  
Marie-Pierre Rivière ◽  
Sophie Pagnotta ◽  
Emmanuel Baudouin ◽  
Franck Panabières ◽  
...  
Keyword(s):  
Cell Death ◽  
Phytophthora Parasitica ◽  
Oomycete Pathogen

scholarly journals Alpha-Synuclein Modulates [Ca2+]c of Neurons and Astrocytes that Trigger Cell Death

2014 ◽  
Vol 106 (2) ◽  
pp. 529a
Author(s):  
Plamena R. Stroh ◽  
Marthe H.R. Ludtmann ◽  
Nicholas W. Wood ◽  
David Klenerman ◽  
Sonia Gandhi ◽  
...  
Keyword(s):  
Cell Death ◽  
Alpha Synuclein ◽  
Trigger Cell Death
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