Role of the major determinant of polar flagellation FlhG in the endoflagella‐containing spirochete Leptospira

2021 ◽  
Author(s):  
Lenka Fule ◽  
Ruben Halifa ◽  
Celia Fontana ◽  
Odile Sismeiro ◽  
Rachel Legendre ◽  
...  
Keyword(s):  
Major Determinant

The Familiar-Size Cue to Depth under Reduced-Cue Viewing Conditions

Perception ◽  
1994 ◽  
Vol 23 (11) ◽  
pp. 1301-1312 ◽  
Author(s):  
John Predebon ◽  
Jacob Steven Woolley
Keyword(s):  
Motion Parallax ◽  
Verbal Report ◽  
Major Determinant ◽  
Relative Distance ◽  
Head Motion ◽  
Familiar Size ◽  
Verbal Reports ◽  
Direct Reports ◽  
Visual Conditions

The familiar-size cue to perceived depth was investigated in five experiments. The stimuli were stationary familiar objects viewed monocularly under otherwise completely darkened visual conditions. Perceived depth was measured directly with the method of verbal report and indirectly with the head-motion procedure. Although the familiar-size cue influenced verbal reports of the distances of the objects, it did not determine perceived depth as assessed with the head-motion procedure. These findings support the claim that familiar size is not a major determinant of perceived depth, and that cognitive or nonperceptual factors mediate the effects of familiar size on direct reports of depth and distance. Possible reasons for the failure of familiar size to influence the head-motion-derived measures of perceived depth are discussed with particular emphasis on the role of motion parallax in determining perceptions of depth and relative distance.

The role of precision in determining the performance of a thyrotropin assay in diagnosing hyperthyroidism.

1988 ◽  
Vol 34 (7) ◽  
pp. 1464-1467 ◽  
Author(s):  
T J Wilke ◽  
D J Utley
Keyword(s):  
Lower Limit ◽  
Diagnostic Performance ◽  
Reference Interval ◽  
Major Determinant ◽  
Analytical Sensitivity ◽  
Diagnostic Efficiency ◽  
Immunometric Assay ◽  
Coefficients Of Variations ◽  
The Relationship

Abstract We examined the relationship between analytical sensitivity, precision at the lower limit of the reference interval, and diagnostic performance in hyperthyroidism for one radioimmunoassay and five immunometric assay kits for thyrotropin. The analytical sensitivity of these kits extended from 0.05 to 1.56 milli-int. units/L. Diagnostic efficiencies of the immunometric assays, in discriminating between euthyroidism and hyperthyroidism, ranged between 93% and 98%. There was a highly significant correlation (r = 0.99, P less than 0.001) between analytical sensitivity and diagnostic efficiency. The between-assay coefficients of variations, at the lower limit of the reference interval, ranged from 26% to 87%. There was no correlation (r = 0.36) between precision, at this concentration, and diagnostic efficiency. We conclude that analytical sensitivity and not precision is the major determinant in controlling the diagnostic performance of a thyrotropin assay in hyperthyroidism.

Difficulty matters: Unspecific attentional demands as a major determinant of performance highlighted by clinical studies

2013 ◽  
Vol 36 (6) ◽  
pp. 680-681 ◽  
Author(s):  
Mario Bonato ◽  
Marco Zorzi ◽  
Carlo Umiltà
Keyword(s):  
Clinical Studies ◽  
Task Difficulty ◽  
Right Hemisphere ◽  
Cognitive Impairments ◽  
Major Determinant ◽  
Dual Tasks ◽  
Attentional Demands

AbstractThe cognitive impairments shown by brain-damaged patients emphasize the role of task difficulty as a major determinant for performance. We discuss the proposal of Kurzban et al. in light of our findings on right-hemisphere–damaged patients, who show increasing awareness deficits for the contralesional hemispace when engaged with resource-consuming dual tasks. This phenomenon is readily explained by the assumption of unspecific depletable resources.

The interaction between phosphoryl transferase and submitochondrial particles

1968 ◽  
Vol 46 (7) ◽  
pp. 677-683 ◽  
Author(s):  
Robert E. Beyer
Keyword(s):  
Adenine Nucleotide ◽  
Major Determinant ◽  
Phosphoryl Group ◽  
Antimycin A ◽  
Submitochondrial Particles ◽  
Phosphorylated Form ◽  
Mitochondrial Transfer ◽  
Probable Role ◽  
Phosphoryl Groups

The interaction between purified phosphoryl transferase and submitochondrial particles has been studied. In the presence of submitochondrial particles the transferase is phosphorylated and the phosphorylated form of the transferase is dephosphorylated. Both of these interactions require that the particle be actively carrying out oxidation of succinate or NADH. Both antimycin A and oligomycin suppress the phosphorylation and dephosphorylation reactions. The uncoupler p-trifluoromethoxy-carbonylcyanide phenylhydrazone prevents the particle-mediated phosphorylation of the transferase but stimulates the dephosphorylation of the phosphorylated transferase to a slight extent. The concentration of bound adenine nucleotide in the particles appears to be a major determinant of the rate of phosphorylation of the transferase, and this dependence is consistent with the fact that the transfer of a phosphoryl group from the phosphorylated transferase to ADP proceeds rapidly and spontaneously. The probable role of the transferase in the mitochondrial transfer of phosphoryl groups from endogenous ATP to exogenous ADP is evaluated.

scholarly journals Role of Nitrogen Limitation in Transformation of RDX (Hexahydro-1,3,5-Trinitro-1,3,5-Triazine) by Gordonia sp. Strain KTR9

2012 ◽  
Vol 79 (5) ◽  
pp. 1746-1750 ◽  
Author(s):  
Karl J. Indest ◽  
Dawn E. Hancock ◽  
Carina M. Jung ◽  
Jed O. Eberly ◽  
William W. Mohn ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitrogen Limitation ◽  
Nitrogen Availability ◽  
Major Determinant ◽  
Content Type

ABSTRACTThe transcriptome of RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine)-degrading strainGordoniasp. strain KTR9 and itsglnRmutant were studied as a function of nitrogen availability to further investigate the observed ammonium-mediated inhibition of RDX degradation. The results indicate that nitrogen availability is a major determinant of RDX degradation andxplAgene expression in KTR9.

scholarly journals Pathogenesis of Chimeric MHV4/MHV-A59 Recombinant Viruses: the Murine Coronavirus Spike Protein Is a Major Determinant of Neurovirulence

1999 ◽  
Vol 73 (9) ◽  
pp. 7752-7760 ◽  
Author(s):  
Joanna J. Phillips ◽  
Ming Ming Chua ◽  
Ehud Lavi ◽  
Susan R. Weiss
Keyword(s):  
Hepatitis Virus ◽  
Major Determinant ◽  
Rna Recombination ◽  
Wild Type ◽  
Recombinant Viruses ◽  
S Gene ◽  
The Central Nervous System ◽  
Plaque Phenotype ◽  
The Brain

ABSTRACT The mouse hepatitis virus (MHV) spike glycoprotein, S, has been implicated as a major determinant of viral pathogenesis. In the absence of a full-length molecular clone, however, it has been difficult to address the role of individual viral genes in pathogenesis. By using targeted RNA recombination to introduce the S gene of MHV4, a highly neurovirulent strain, into the genome of MHV-A59, a mildly neurovirulent strain, we have been able to directly address the role of the S gene in neurovirulence. In cell culture, the recombinants containing the MHV4 S gene, S4R22 and S4R21, exhibited a small-plaque phenotype and replicated to low levels, similar to wild-type MHV4. Intracranial inoculation of C57BL/6 mice with S4R22 and S4R21 revealed a marked alteration in pathogenesis. Relative to wild-type control recombinant viruses (wtR13 and wtR9), containing the MHV-A59 S gene, the MHV4 S gene recombinants exhibited a dramatic increase in virulence and an increase in both viral antigen staining and inflammation in the central nervous system. There was not, however, an increase in the level of viral replication in the brain. These studies demonstrate that the MHV4 S gene alone is sufficient to confer a highly neurovirulent phenotype to a recombinant virus deriving the remainder of its genome from a mildly neurovirulent virus, MHV-A59. This definitively confirms previous findings, suggesting that the spike is a major determinant of pathogenesis.

scholarly journals MEIS1 in Hematopoiesis and Cancer. How MEIS1-PBX Interaction Can Be Used in Therapy

2021 ◽  
Vol 9 (4) ◽  
pp. 44
Author(s):  
Francesco Blasi ◽  
Chiara Bruckmann
Keyword(s):  
Cancer Cells ◽  
Major Determinant ◽  
Profound Knowledge ◽  
Effective Drugs

Recently MEIS1 emerged as a major determinant of the MLL-r leukemic phenotype. The latest and most efficient drugs effectively decrease the levels of MEIS1 in cancer cells. Together with an overview of the latest drugs developed to target MEIS1 in MLL-r leukemia, we review, in detail, the role of MEIS1 in embryonic and adult hematopoiesis and suggest how a more profound knowledge of MEIS1 biochemistry can be used to design potent and effective drugs against MLL-r leukemia. In addition, we present data showing that the interaction between MEIS1 and PBX1 can be blocked efficiently and might represent a new avenue in anti-MLL-r and anti-leukemic therapy.

scholarly journals Hyperglycemia Is a Major Determinant of Albumin Permeability in Diabetic Microcirculation: The Role of  -Calpain

Diabetes ◽  
2007 ◽  
Vol 56 (7) ◽  
pp. 1842-1849 ◽  
Author(s):  
R. Scalia ◽  
Y. Gong ◽  
B. Berzins ◽  
L. J. Zhao ◽  
K. Sharma
Keyword(s):  
Major Determinant

Conditioned feeding responses in sheep towards flavoured foods associated with casein administration: the role of long delay learning

1999 ◽  
Vol 1999 ◽  
pp. 210-210
Author(s):  
G. Arsenos ◽  
J. Hills ◽  
I. Kyriazakis
Keyword(s):  
Major Determinant ◽  
Temporal Contiguity ◽  
Novel Food ◽  
Conditioned Responses

Various studies in animals have shown conditioned responses toward food flavours created through their associations with positive or negative post-ingestive consequences (PIC). Essentially these studies presume a temporal contiguity, as necessary in permitting associations, and that flavours are a major determinant of such responses. It has been shown that associations between a novel food flavour and subsequent negative PIC can also be formed even when they are disassociated in time (long delay learning); no such evidence exists for this type of learning from positive PIC (Capaldi, 1992). In this study two objectives were tested: (i) whether such associations could be established with delays between consumption of a flavoured food and positive or negative PIC resulting from casein administration, and (ii) how these associations are affected by initial responses towards food flavours.

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