Manganese impairs the QoxABCD terminal oxidase leading to respiration‐associated toxicity

2021 ◽  
Author(s):  
Ankita J. Sachla ◽  
Yuanchan Luo ◽  
John D. Helmann
Keyword(s):  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amer H. Asseri ◽  
Albert Godoy-Hernandez ◽  
Hojjat Ghasemi Goojani ◽  
Holger Lill ◽  
Junshi Sakamoto ◽  
...  

AbstractCardiolipin (CL) is a lipid that is found in the membranes of bacteria and the inner membranes of mitochondria. CL can increase the activity of integral membrane proteins, in particular components of respiratory pathways. We here report that CL activated detergent-solubilized cytochrome bd, a terminal oxidase from Escherichia coli. CL enhanced the oxygen consumption activity ~ twofold and decreased the apparent KM value for ubiquinol-1 as substrate from 95 µM to 35 µM. Activation by CL was also observed for cytochrome bd from two Gram-positive species, Geobacillus thermodenitrificans and Corynebacterium glutamicum, and for cytochrome bo3 from E. coli. Taken together, CL can enhance the activity of detergent-solubilized cytochrome bd and cytochrome bo3.


1989 ◽  
Vol 165 (3) ◽  
pp. 1110-1114 ◽  
Author(s):  
Takayoshi Wakagi ◽  
Tatsuo Yamauchi ◽  
Tairo Oshima ◽  
Michele Müller ◽  
Angello Azzi ◽  
...  

2003 ◽  
Vol 270 (18) ◽  
pp. 3787-3794 ◽  
Author(s):  
Eve-Marie Josse ◽  
Jean-Pierre Alcaraz ◽  
Anne-Marie Laboure ◽  
Marcel Kuntz

Sign in / Sign up

Export Citation Format

Share Document