scholarly journals Deciphering the Che2 chemosensory pathway and the roles of individual Che2 proteins from Pseudomonas aeruginosa

2020 ◽  
Author(s):  
Emilie Orillard ◽  
Kylie J. Watts
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Chemosensory Pathway

scholarly journals Autolysis and Autoaggregation in Pseudomonas aeruginosa Colony Morphology Mutants

2002 ◽  
Vol 184 (23) ◽  
pp. 6481-6489 ◽  
Author(s):  
David A. D'Argenio ◽  
M. Worth Calfee ◽  
Paul B. Rainey ◽  
Everett C. Pesci
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Natural Populations ◽  
Transposon Insertion ◽  
Extracellular Signal ◽  
Chemosensory Pathway ◽  
Ggdef Domain ◽  
The Many ◽  
Suppressor Analysis ◽  
Fimbrial Adhesin ◽  
Insertion Mutants

ABSTRACT Two distinctive colony morphologies were noted in a collection of Pseudomonas aeruginosa transposon insertion mutants. One set of mutants formed wrinkled colonies of autoaggregating cells. Suppressor analysis of a subset of these mutants showed that this was due to the action of the regulator WspR and linked this regulator (and the chemosensory pathway to which it belongs) to genes that encode a putative fimbrial adhesin required for biofilm formation. WspR homologs, related in part by a shared GGDEF domain, regulate cell surface factors, including aggregative fimbriae and exopolysaccharides, in diverse bacteria. The second set of distinctive insertion mutants formed colonies that lysed at their center. Strains with the most pronounced lysis overproduced the Pseudomonas quinolone signal (PQS), an extracellular signal that interacts with quorum sensing. Autolysis was suppressed by mutation of genes required for PQS biosynthesis, and in one suppressed mutant, autolysis was restored by addition of synthetic PQS. The mechanism of autolysis may involve activation of the endogenous prophage and phage-related pyocins in the genome of strain PAO1. The fact that PQS levels correlated with autolysis suggests a fine balance in natural populations of P. aeruginosa between survival of the many and persistence of the few.

scholarly journals Pseudomonas aeruginosa as a Model To Study Chemosensory Pathway Signaling

2021 ◽  
Vol 85 (1) ◽  
Author(s):  
Miguel A. Matilla ◽  
David Martín-Mora ◽  
Jose A. Gavira ◽  
Tino Krell
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Model Organism ◽  
Diverse Range ◽  
Content Type ◽  
Physiological Relevance ◽  
Primary Model ◽  
Chemosensory Pathway ◽  
Transduction Mechanisms ◽  
Pathway Function ◽  
Chemosensory Pathways

SUMMARY Bacteria have evolved a variety of signal transduction mechanisms that generate different outputs in response to external stimuli. Chemosensory pathways are widespread in bacteria and are among the most complex signaling mechanisms, requiring the participation of at least six proteins. These pathways mediate flagellar chemotaxis, in addition to controlling alternative functions such as second messenger levels or twitching motility. The human pathogen Pseudomonas aeruginosa has four different chemosensory pathways that carry out different functions and are stimulated by signal binding to 26 chemoreceptors. Recent research employing a diverse range of experimental approaches has advanced enormously our knowledge on these four pathways, establishing P. aeruginosa as a primary model organism in this field. In the first part of this article, we review data on the function and physiological relevance of chemosensory pathways as well as their involvement in virulence, whereas the different transcriptional and posttranscriptional regulatory mechanisms that govern pathway function are summarized in the second part. The information presented will be of help to advance the understanding of pathway function in other organisms.

Effekt von Acetylcystein auf die Pseudomonas aeruginosa-induzierte Mukusexpression

Pneumologie ◽  
2010 ◽  
Vol 64 (01) ◽  
Author(s):  
L Sprenger ◽  
T Goldmann ◽  
E Vollmer ◽  
B Wollenberg ◽  
P Zabel ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa

Effekt von Dexamethason auf die Pseudomonas aeruginosa-induzierte Mukusexpression in humaner Atemwegsmukosa

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
L Spenger ◽  
T Goldmann ◽  
E Vollmer ◽  
B Wollenberg ◽  
HP Hauber ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa
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