Coordinated regulation of anthranilate metabolism and bacterial virulence by the GntR family regulator MpaR in Pseudomonas aeruginosa

2020 ◽  
Vol 114 (5) ◽  
pp. 857-869
Author(s):  
Tietao Wang ◽  
Yihang Qi ◽  
Zhihan Wang ◽  
Jingru Zhao ◽  
Linxuan Ji ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Bacterial Virulence ◽  
Coordinated Regulation ◽  
Gntr Family

scholarly journals Black sea cucumber (Holothuria atra Jaeger, 1833) rescues Pseudomonas aeruginosa-infected Caenorhabditis elegans via reduction of pathogen virulence factors and enhancement of host immunity

2019 ◽  
Vol 10 (9) ◽  
pp. 5759-5767
Author(s):  
Wan-Ting Lee ◽  
Boon-Khai Tan ◽  
Su-Anne Eng ◽  
Gan Chee Yuen ◽  
Kit Lam Chan ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Virulence Factors ◽  
Black Sea ◽  
Sea Cucumber ◽  
Multidrug Resistant ◽  
Host Immunity ◽  
Bacterial Virulence ◽  
Pathogen Virulence ◽  
Multidrug Resistant Pathogens ◽  
Holothuria Atra

A strategy to circumvent the problem of multidrug resistant pathogens is the discovery of anti-infectives targeting bacterial virulence or host immunity.

scholarly journals Molecular insights into the master regulator CysB‐mediated bacterial virulence in Pseudomonas aeruginosa

2019 ◽  
Vol 111 (5) ◽  
pp. 1195-1210 ◽  
Author(s):  
Yaqin Song ◽  
Chun Yang ◽  
Gukui Chen ◽  
Yixi Zhang ◽  
Zijing Seng ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Bacterial Virulence ◽  
Master Regulator

scholarly journals Daphnia magna, a Host for Evaluation of Bacterial Virulence

2011 ◽  
Vol 78 (2) ◽  
pp. 593-595 ◽  
Author(s):  
Marion Le Coadic ◽  
Marianne Simon ◽  
Anna Marchetti ◽  
Dieter Ebert ◽  
Pierre Cosson
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Content Analysis ◽  
Human Health ◽  
Daphnia Magna ◽  
Bacterial Virulence ◽  
Content Type ◽  
Bacterial Mutants

ABSTRACTWe show thatDaphnia magnacan be used to assess acute virulence of pathogens relevant to human health, such asPseudomonas aeruginosaorPhotorhabdus asymbiotica. Analysis of bacterial mutants suggests thatP. aeruginosauses similar mechanisms to infectDaphniaand other hosts.

scholarly journals High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents

mBio ◽  
2021 ◽  
Vol 12 (3) ◽  
Author(s):  
Donghoon Kang ◽  
Liyang Zhang ◽  
Natalia V. Kirienko
Keyword(s):  
Pseudomonas Aeruginosa ◽  
High Throughput ◽  
Bacterial Virulence ◽  
Special Focus ◽  
Content Type ◽  
Opportunistic Human Pathogen ◽  
New Treatments ◽  
High Throughput Screens ◽  
Synthetic Small Molecule ◽  
New Strategies

ABSTRACT Antimicrobial resistance is a serious medical threat, particularly given the decreasing rate of discovery of new treatments. Although attempts to find new treatments continue, it has become clear that merely discovering new antimicrobials, even if they are new classes, will be insufficient. It is essential that new strategies be aggressively pursued. Toward that end, the search for treatments that can mitigate bacterial virulence and tilt the balance of host-pathogen interactions in favor of the host has become increasingly popular. In this review, we will discuss recent progress in this field, with a special focus on synthetic small molecule antivirulents that have been identified from high-throughput screens and on treatments that are effective against the opportunistic human pathogen Pseudomonas aeruginosa.

scholarly journals Pseudomonas aeruginosa nfuA: Gene regulation and its physiological roles in sustaining growth under stress and anaerobic conditions and maintaining bacterial virulence

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202151 ◽  
Author(s):  
Adisak Romsang ◽  
Jintana Duang-nkern ◽  
Kritsakorn Saninjuk ◽  
Paiboon Vattanaviboon ◽  
Skorn Mongkolsuk
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Gene Regulation ◽  
Bacterial Virulence ◽  
Anaerobic Conditions

scholarly journals Cinnamide Derivatives of d -Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa

ChemistryOpen ◽  
2015 ◽  
Vol 4 (6) ◽  
pp. 756-767 ◽  
Author(s):  
Roman Sommer ◽  
Dirk Hauck ◽  
Annabelle Varrot ◽  
Stefanie Wagner ◽  
Aymeric Audfray ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Virulence Factor ◽  
Bacterial Virulence ◽  
Bacterial Virulence Factor ◽  
Derivatives Of
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