Regulation of toxic shock syndrome toxin‐1 by the accessory gene regulator in Staphylococcus aureus is mediated by the repressor of toxins

2019 ◽  
Vol 112 (4) ◽  
pp. 1163-1177 ◽  
Author(s):  
Stephen W. Tuffs ◽  
Christine A. Herfst ◽  
Miren L. Baroja ◽  
Vladyslav A. Podskalniy ◽  
Erica N. DeJong ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Accessory Gene ◽  
Accessory Gene Regulator ◽  
Toxic Shock Syndrome Toxin

Monoclonal Antibodies to the Enterotoxins and to the Toxic Shock Syndrome Toxin Produced by Staphylococcus aureus

1985 ◽  
pp. 23-59 ◽  
Author(s):  
NANCY E. THOMPSON ◽  
MERLIN S. BERGDOLL ◽  
RICHARD F. MEYER ◽  
REGINALD W. BENNETT ◽  
LLONAS MILLER ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Monoclonal Antibodies ◽  
Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Toxic Shock Syndrome Toxin

scholarly journals Exotoxins of Staphylococcus aureus

2000 ◽  
Vol 13 (1) ◽  
pp. 16-34 ◽  
Author(s):  
Martin M. Dinges ◽  
Paul M. Orwin ◽  
Patrick M. Schlievert
Keyword(s):  
Staphylococcus Aureus ◽  
Toxic Shock Syndrome ◽  
Molecular Basis ◽  
Molecular Mechanisms ◽  
Food Poisoning ◽  
Structure And Function ◽  
Toxic Shock ◽  
The Family ◽  
Toxic Shock Syndrome Toxin ◽  
And Function

SUMMARY This article reviews the literature regarding the structure and function of two types of exotoxins expressed by Staphylococcus aureus, pyrogenic toxin superantigens (PTSAgs) and hemolysins. The molecular basis of PTSAg toxicity is presented in the context of two diseases known to be caused by these exotoxins: toxic shock syndrome and staphylococcal food poisoning. The family of staphylococcal PTSAgs presently includes toxic shock syndrome toxin-1 (TSST-1) and most of the staphylococcal enterotoxins (SEs) (SEA, SEB, SEC, SED, SEE, SEG, and SEH). As the name implies, the PTSAgs are multifunctional proteins that invariably exhibit lethal activity, pyrogenicity, superantigenicity, and the capacity to induce lethal hypersensitivity to endotoxin. Other properties exhibited by one or more staphylococcal PTSAgs include emetic activity (SEs) and penetration across mucosal barriers (TSST-1). A detailed review of the molecular mechanisms underlying the toxicity of the staphylococcal hemolysins is also presented.

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