Substrate recognition by the bacterial type II secretion system: more than a simple interaction

2014 ◽  
Vol 94 (1) ◽  
pp. 126-140 ◽  
Author(s):  
Camille Pineau ◽  
Natalia Guschinskaya ◽  
Xavier Robert ◽  
Patrice Gouet ◽  
Lionel Ballut ◽  
...  
Keyword(s):  
Substrate Recognition ◽  
Secretion System ◽  
Type Ii Secretion ◽  
Type Ii ◽  
Type Ii Secretion System ◽  
Bacterial Type ◽  
Simple Interaction

scholarly journals In Situ Investigations of the Bacterial Type II Secretion System

2020 ◽  
Vol 26 (S2) ◽  
pp. 2734-2735
Author(s):  
Zhili Yu ◽  
Tong Huo ◽  
Muyuan Chen ◽  
Xiaodong Shi ◽  
Steven Ludtke ◽  
...  
Keyword(s):  
Secretion System ◽  
Type Ii Secretion ◽  
Type Ii ◽  
Type Ii Secretion System ◽  
Bacterial Type

scholarly journals Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lenka Horváthová ◽  
Vojtěch Žárský ◽  
Tomáš Pánek ◽  
Romain Derelle ◽  
Jan Pyrih ◽  
...  
Keyword(s):  
Functional Data ◽  
Secretion System ◽  
Type Ii Secretion ◽  
Type Ii ◽  
Type Ii Secretion System ◽  
Biochemical Assays ◽  
Functional Pathway ◽  
Bacterial Type ◽  
Different Parts

AbstractThe type 2 secretion system (T2SS) is present in some Gram-negative eubacteria and used to secrete proteins across the outer membrane. Here we report that certain representative heteroloboseans, jakobids, malawimonads and hemimastigotes unexpectedly possess homologues of core T2SS components. We show that at least some of them are present in mitochondria, and their behaviour in biochemical assays is consistent with the presence of a mitochondrial T2SS-derived system (miT2SS). We additionally identified 23 protein families co-occurring with miT2SS in eukaryotes. Seven of these proteins could be directly linked to the core miT2SS by functional data and/or sequence features, whereas others may represent different parts of a broader functional pathway, possibly also involving the peroxisome. Its distribution in eukaryotes and phylogenetic evidence together indicate that the miT2SS-centred pathway is an ancestral eukaryotic trait. Our findings thus have direct implications for the functional properties of the early mitochondrion.

scholarly journals Ancestral mitochondrial apparatus derived from the bacterial type II secretion system

2019 ◽  
Author(s):  
Lenka Horváthová ◽  
Vojtěch Žárský ◽  
Tomáš Pánek ◽  
Romain Derelle ◽  
Jan Pyrih ◽  
...  
Keyword(s):  
Functional Data ◽  
Secretion System ◽  
Type Ii Secretion ◽  
Type Ii ◽  
Type Ii Secretion System ◽  
Biochemical Assays ◽  
Protein Secretion System ◽  
Functional Pathway ◽  
Bacterial Type

AbstractThe type 2 secretion system (T2SS) is present in some Gram-negative eubacteria and used to secrete proteins across the outer membrane. Here we report that certain representative heteroloboseans, jakobids, malawimonads and hemimastigotes unexpectedly possess homologues of core T2SS components. We show that at least some of them are present in mitochondria, and their behaviour in biochemical assays is consistent with the formation of a mitochondrial T2SS-derived protein secretion system (miT2SS). We additionally identified 23 protein families co-occurring with miT2SS in eukaryotes. Seven of these proteins could be directly linked to the core miT2SS by functional data and/or sequence features, whereas others may represent different parts of a broader functional pathway, possibly also involving the peroxisome. Its distribution in eukaryotes and phylogenetic evidence together indicate that the miT2SS-centred pathway is an ancestral eukaryotic trait. Our findings thus have direct implications for the functional properties of the early mitochondrion.

scholarly journals The structure and mechanism of the bacterial type II secretion system

2020 ◽  
Author(s):  
Souvik Naskar ◽  
Michael Hohl ◽  
Matteo Tassinari ◽  
Harry H. Low
Keyword(s):  
Secretion System ◽  
Type Ii Secretion ◽  
Type Ii ◽  
Type Ii Secretion System ◽  
Bacterial Type

scholarly journals Solution Structure of Homology Region (HR) Domain of Type II Secretion System

2012 ◽  
Vol 287 (12) ◽  
pp. 9072-9080 ◽  
Author(s):  
Shuang Gu ◽  
Geoff Kelly ◽  
Xiaohui Wang ◽  
Tom Frenkiel ◽  
Vladimir E. Shevchik ◽  
...  
Keyword(s):  
Solution Structure ◽  
Secretion System ◽  
Type Ii Secretion ◽  
Type Ii ◽  
Homology Region ◽  
Type Ii Secretion System
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