Lies and deception in bacterial gene regulation: the roles of nucleic acid decoys

2014 ◽  
Vol 92 (4) ◽  
pp. 641-647 ◽  
Author(s):  
Yvonne Göpel ◽  
Boris Görke
Keyword(s):  
Gene Regulation ◽  
Nucleic Acid ◽  
Bacterial Gene

A GATA3 Targeting Nucleic Acid Nanocapsule for In Vivo Gene Regulation in Asthma

ACS Nano ◽  
2021 ◽  
Author(s):  
Tyler D. Gavitt ◽  
Alyssa K. Hartmann ◽  
Shraddha S. Sawant ◽  
Arlind B. Mara ◽  
Steven M. Szczepanek ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Nucleic Acid

scholarly journals In planta bacterial multi-omics analysis illuminates regulatory principles underlying plant-pathogen interactions

2019 ◽  
Author(s):  
Tatsuya Nobori ◽  
Yiming Wang ◽  
Jingni Wu ◽  
Sara Christina Stolze ◽  
Yayoi Tsuda ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Pseudomonas Syringae ◽  
Protein Level ◽  
Plant Pathogens ◽  
Plant Immunity ◽  
Bacterial Pathogen ◽  
Bacterial Virulence ◽  
In Planta ◽  
Bacterial Gene ◽  
Global Food Security

AbstractUnderstanding how gene expression is regulated in plant pathogens is crucial for pest control and thus global food security. An integrated understanding of bacterial gene regulation in the host is dependent on multi-omic datasets, but these are largely lacking. Here, we simultaneously characterized the transcriptome and proteome of a foliar bacterial pathogen, Pseudomonas syringae, in Arabidopsis thaliana and identified a number of bacterial processes influenced by plant immunity at the mRNA and the protein level. We found instances of both concordant and discordant regulation of bacterial mRNAs and proteins. Notably, the tip component of bacterial type III secretion system was selectively suppressed by the plant salicylic acid pathway at the protein level, suggesting protein-level targeting of the bacterial virulence system by plant immunity. Furthermore, gene co-expression analysis illuminated previously unknown gene regulatory modules underlying bacterial virulence and their regulatory hierarchy. Collectively, the integrated in planta bacterial omics approach provides molecular insights into multiple layers of bacterial gene regulation that contribute to bacterial growth in planta and elucidate the role of plant immunity in controlling pathogens.

Biophysical Approaches to Bacterial Gene Regulation by Riboswitches

2016 ◽  
pp. 157-191 ◽  
Author(s):  
Cibran Perez-Gonzalez ◽  
Jonathan P. Grondin ◽  
Daniel A. Lafontaine ◽  
J. Carlos Penedo
Keyword(s):  
Gene Regulation ◽  
Bacterial Gene

scholarly journals Who turned on the lights?: What the regulation of bacterial bioluminescence tells us about this and other bacterial group behaviours

2013 ◽  
Vol 35 (5) ◽  
pp. 18-23 ◽  
Author(s):  
Eric V. Stabb ◽  
Zomary Flores-Cruz
Keyword(s):  
Gene Regulation ◽  
Group Activity ◽  
Bacterial Group ◽  
Bacterial Gene ◽  
Bioluminescent Bacteria ◽  
Regulatory Decision ◽  
Bacterial Bioluminescence ◽  
Regulatory Circuits ◽  
Pheromone Signalling

Luminescence produced by organisms, or ‘bioluminescence’, holds a distinct fascination for humankind, and the study of bacterial bioluminescence has a long history in the field of microbiology. Advances in our understanding of bacterial bioluminescence have in many ways paralleled advances in the field as a whole. Intriguingly, studies of bioluminescent bacteria led to a seminal discovery in bacterial gene regulation and behaviour, because for bacteria, bioluminescence is a group activity. Bioluminescent bacteria communicate using pheromones, and as a result the regulatory decision to induce bioluminescence is only made if a group of bacteria has achieved a dense enough population to allow the build-up of pheromone. More recently, it has become clear that there are complex regulatory circuits governing not only luminescence, but also pheromone signalling itself. These additional layers of regulation pose new questions such as what are bacteria really saying to each other? Understanding regulation may also help answer ancient questions including, what use is luminescence?

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