scholarly journals Molecular determinants of beta-adrenergic signaling to voltage-gated K+channels in the cerebral circulation

2018 ◽  
Vol 25 (1) ◽  
pp. e12425 ◽  
Author(s):  
Sung W. Rhee ◽  
Nancy J. Rusch
Keyword(s):  
Cerebral Circulation ◽  
Beta Adrenergic ◽  
Adrenergic Signaling ◽  
K Channels ◽  
Voltage Gated ◽  
Molecular Determinants

scholarly journals Localization and Molecular Determinants of the Hanatoxin Receptors on the Voltage-Sensing Domains of a K+ Channel

2000 ◽  
Vol 115 (6) ◽  
pp. 673-684 ◽  
Author(s):  
Yingying Li-Smerin ◽  
Kenton J. Swartz
Keyword(s):  
K Channel ◽  
Alanine Scanning Mutagenesis ◽  
Voltage Sensing ◽  
Alanine Scanning ◽  
K Channels ◽  
Voltage Gated ◽  
Physical Location ◽  
Molecular Determinants ◽  
Central Pore ◽  
Pore Domain

Hanatoxin inhibits voltage-gated K+ channels by modifying the energetics of activation. We studied the molecular determinants and physical location of the Hanatoxin receptors on the drk1 voltage-gated K+ channel. First, we made multiple substitutions at three previously identified positions in the COOH terminus of S3 to examine whether these residues interact intimately with the toxin. We also examined a region encompassing S1–S3 using alanine-scanning mutagenesis to identify additional determinants of the toxin receptors. Finally, guided by the structure of the KcsA K+ channel, we explored whether the toxin interacts with the peripheral extracellular surface of the pore domain in the drk1 K+ channel. Our results argue for an intimate interaction between the toxin and the COOH terminus of S3 and suggest that the Hanatoxin receptors are confined within the voltage-sensing domains of the channel, at least 20–25 Å away from the central pore axis.

Challenging the Adipocyte Color Barrier—TR Activation Elicits White to Beige Transdifferentiation Independent of Beta-Adrenergic Signaling

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2039-P
Author(s):  
YAN XIA ◽  
XIAOFEI LIANG ◽  
MARK E. LEE ◽  
KEVIN PHILLIPS
Keyword(s):  
Beta Adrenergic ◽  
Adrenergic Signaling

scholarly journals Regulation of voltage-gated K+channels by glucose metabolism in pancreatic β-cells

FEBS Letters ◽  
2009 ◽  
Vol 583 (13) ◽  
pp. 2225-2230 ◽  
Author(s):  
Masashi Yoshida ◽  
Katsuya Dezaki ◽  
Shiho Yamato ◽  
Atsushi Aoki ◽  
Hitoshi Sugawara ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
K Channels ◽  
Voltage Gated

scholarly journals Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Nina E Ottosson ◽  
Xiongyu Wu ◽  
Andreas Nolting ◽  
Urban Karlsson ◽  
Per-Eric Lund ◽  
...  
Keyword(s):  
Neuronal Excitability ◽  
Resin Acid ◽  
K Channels ◽  
Voltage Gated

scholarly journals Voltage‐gated K+ Channels as Potential Therapeutic Targets for Lung Adenocarcinoma Therapy

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
SO YEONG LEE ◽  
SOO HWA JANG ◽  
SUN YOUNG CHOI ◽  
PAN DONG RYU
Keyword(s):  
Lung Adenocarcinoma ◽  
Therapeutic Targets ◽  
K Channels ◽  
Voltage Gated

scholarly journals Charybdotoxin blocks both Ca-activated K channels and Ca-independent voltage-gated K channels in rat brain synaptosomes

FEBS Letters ◽  
1989 ◽  
Vol 250 (2) ◽  
pp. 433-436 ◽  
Author(s):  
M.J. Schneider ◽  
R.S. Rogowski ◽  
B.K. Krueger ◽  
M.P. Blaustein
Keyword(s):  
Rat Brain ◽  
K Channels ◽  
Voltage Gated ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

Molecular Determinants of Inactivation and Dofetilide Block inether a-go-go (EAG) Channels and EAG-Related K+ Channels

2001 ◽  
Vol 60 (6) ◽  
pp. 1343-1348 ◽  
Author(s):  
Eckhard Ficker ◽  
Wolfgang Jarolimek ◽  
Arthur M. Brown
Keyword(s):  
K Channels ◽  
Molecular Determinants ◽  
Eag Channels
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