scholarly journals The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue

2017 ◽  
Vol 24 (3) ◽  
pp. e12337 ◽  
Author(s):  
Adrien Lücker ◽  
Timothy W. Secomb ◽  
Bruno Weber ◽  
Patrick Jenny
Keyword(s):  
Blood Cell ◽  
Oxygen Transport ◽  
Red Blood Cell ◽  
Relative Influence ◽  
Cell Velocity ◽  
Red Blood Cell Velocity

Influence of hemoconcentration on arteriolar oxygen transport in hamster striated muscle

1990 ◽  
Vol 259 (6) ◽  
pp. H1694-H1702 ◽  
Author(s):  
L. Kuo ◽  
R. N. Pittman
Keyword(s):  
Blood Cell ◽  
Oxygen Transport ◽  
Red Blood Cell ◽  
Oxygen Flow ◽  
Cheek Pouch ◽  
Surrounding Tissue ◽  
Segment Length ◽  
Retractor Muscle ◽  
Cell Velocity ◽  
Red Blood Cell Velocity

We investigated the influence of isovolemic hemoconcentration on microcirculatory hemodynamics and oxygen transport in the hamster cheek pouch retractor muscle. In 17 hamsters, measurements of red blood cell velocity, hematocrit, vessel diameter, segment length (L), hemoglobin oxygen saturation (SO2), and longitudinal SO2 gradient (delta SO2/L) were made in four branching orders of arterioles before and after isovolemic exchange with packed red blood cells. Hemoconcentration increased systemic hematocrit from 50 to 65%; systemic blood gases were unchanged, but mean arterial blood pressure increased approximately 10 mmHg. Accompanying this change in systemic hematocrit the microcirculatory hematocrit increased from 40 to 50%, and red blood cell velocity and computed blood flow decreased approximately 40 and 30%, respectively. In addition, delta SO2/L was significantly increased in the four arteriolar branching orders compared with control values. We estimated that approximately 10% of the oxygen that diffused across the arteriolar network was consumed by the surrounding tissue with the remainder assumed to have diffused to venules and capillaries. After hemoconcentration, the proportion of this diffusional transfer increased by approximately 80%. Convective oxygen flow remained at its control level in the first-order arterioles and progressively decreased below control in the more distal branching orders. Our analysis of arteriolar oxygen diffusion indicated that tissue oxygenation was unchanged after hemoconcentration, a result that can be attributed to a combined effect of decreased red blood cell velocity, arteriolar vasodilation, increased precapillary oxygen loss, and a relatively modest reduction in convective oxygen flow to the capillaries.

Effect of hemodilution on oxygen transport in arteriolar networks of hamster striated muscle

1988 ◽  
Vol 254 (2) ◽  
pp. H331-H339 ◽  
Author(s):  
L. Kuo ◽  
R. N. Pittman
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Fourth Order ◽  
Oxygen Transport ◽  
Red Blood Cell ◽  
Striated Muscle ◽  
Cheek Pouch ◽  
Surrounding Tissue ◽  
Cell Velocity ◽  
Red Blood Cell Velocity

Experiments were performed on the hamster cheek pouch retractor muscle to investigate the influence of isovolemic hemodilution on microcirculatory hemodynamics and the rate of oxygen transport to striated muscle. In 23 hamsters, measurements of red blood cell velocity, hematocrit, vessel diameter, segment length (L), hemoglobin oxygen saturation (SO2), and longitudinal SO2 gradient (delta SO2/L) were made in four branching orders of arterioles before and after isovolemic exchange with plasma. Hemodilution decreased systemic hematocrit from 52 to 33%. In first- through fourth-order arterioles, this degree of hemodilution resulted in an average decrease in microcirculatory hematocrit from 42 to 28% and average increases in red blood cell velocity, computed blood flow, and systemic arterial PO2 of 50, 30, and 10%, respectively. In addition, delta SO2/L was significantly smaller in second-, third-, and fourth order arterioles compared with control values. It was estimated that approximately 84% of the oxygen that diffused across the arteriolar network was transferred by diffusion to nearby venules and capillaries; the remaining oxygen was consumed by the surrounding tissue. Following hemodilution, the magnitude of diffusional transfer declined to 73%. Oxygen flow remained at its control level in the first-order arterioles and progressively increased above control with increasing branching order. The increased oxygen delivery to the capillary network after limited hemodilution can be attributed to a compensatory increase in blood flow, an increase in systemic arterial blood oxygenation, and a decrease in precapillary oxygen loss.

scholarly journals Absence of high red blood cell velocity in the sublingual microcirculation of patients with hyerdynamic septic shock

2015 ◽  
Vol 3 (S1) ◽  
Author(s):  
VS Kanoore Edul ◽  
C Ince ◽  
A Risso Vazquez ◽  
PN Rubatto ◽  
ED Valenzuela Espinoza ◽  
...  
Keyword(s):  
Septic Shock ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Sublingual Microcirculation ◽  
Cell Velocity ◽  
Red Blood Cell Velocity

Ischemia/reperfusion injury in rat mesenteric venules: Red blood cell velocity and leukocyte rolling

1996 ◽  
Vol 31 (4) ◽  
pp. 512-515 ◽  
Author(s):  
Roland J. Beuk ◽  
Mirjam G.A. oude Egbrink ◽  
Harrie A.J.M. Kurvers ◽  
Harm-Jan Bonke ◽  
Geert-Jan Tangelder ◽  
...  
Keyword(s):  
Blood Cell ◽  
Reperfusion Injury ◽  
Red Blood Cell ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Leukocyte Rolling ◽  
Cell Velocity ◽  
Red Blood Cell Velocity
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