Treprostinil Iontophoresis Improves Digital Blood Flow during Local Cooling in Systemic Sclerosis

2016 ◽  
Vol 23 (3) ◽  
pp. 266-270 ◽  
Author(s):  
Florence Gaillard-Bigot ◽  
Matthieu Roustit ◽  
Sophie Blaise ◽  
Claire Cracowski ◽  
Christophe Seinturier ◽  
...  
Keyword(s):  
Blood Flow ◽  
Systemic Sclerosis ◽  
Local Cooling ◽  
Digital Blood Flow

scholarly journals Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis

2021 ◽  
Author(s):  
Cecilia Tito ◽  
Juliana Silvatti ◽  
Izabela N. F. Almeida ◽  
Elise V. Taniguchi ◽  
Tiago Prata ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Systemic Sclerosis ◽  
Ganglion Cell ◽  
Disease Duration ◽  
Optical Coherence ◽  
Swept Source ◽  
Rnfl Thickness ◽  
Structural Abnormalities ◽  
Digital Blood Flow

Abstract PurposeVasospasm represents an early event in systemic sclerosis (SSc). Ocular vasospasm may induce optic nerve head (ONH) damage and has been involved in the pathogenesis of glaucoma, especially normal-tension glaucoma (NTG). We aimed to investigate the presence of structural abnormalities associated with NTG using swept-source optical coherence tomography (SS-OCT) and to correlate the OCT parameters with clinical, capillaroscopy and digital blood flow measures in patients with SSc. MethodsIn this cross-sectional study, 40 patients with SSc and 23 age-matched controls were included. The following parameters were measured using SS-OCT: mean and sectoral retinal nerve fiber layer (RNFL) thickness, macular ganglion cell layer complex (GCC) thickness and ONH morphology. Nailfold capillaroscopy (NFC) and digital blood flow measurements using laser Doppler imaging (LDI) were performed in all subjects. ResultsPatients with SSc showed a thinner temporal RNFL than the controls (69.23 ± 11.74 versus 83.35 ± 20.19 µm, p=0.001). The other parameters were similar between the two groups. In SSc patients, there was an inverse correlation between the disease duration and the average, superior and inferior RNFL thickness and the GCC thickness and between Raynaud’s phenomenon duration and the average RNFL and GCC thickness (p<0.05). NFC and LDI measurements did not show correlations with OCT parameters.ConclusionA thinner temporal RNFL and the correlation between Raynaud’s phenomenon and disease duration and structural abnormalities on OCT suggest the presence of early ganglion cell damage in patients with SSc. Although mild, these findings indicate the need to monitor ocular abnormalities in SSc.

Doppler ultrasound measurement of digital blood flow in systemic sclerosis

1998 ◽  
Vol 7 ◽  
pp. S25
Author(s):  
N. Bregenzer ◽  
U. Müller-Ladner ◽  
O. Distler ◽  
T. Glück ◽  
G. Lock ◽  
...  
Keyword(s):  
Blood Flow ◽  
Systemic Sclerosis ◽  
Doppler Ultrasound ◽  
Ultrasound Measurement ◽  
Digital Blood Flow

scholarly journals Prolonged increase in digital blood flow following iloprost infusion in patients with systemic sclerosis.

1987 ◽  
Vol 63 (742) ◽  
pp. 617-620 ◽  
Author(s):  
M. Rademaker ◽  
R. H. Thomas ◽  
G. Provost ◽  
J. A. Beacham ◽  
E. D. Cooke ◽  
...  
Keyword(s):  
Blood Flow ◽  
Systemic Sclerosis ◽  
Digital Blood Flow ◽  
Iloprost Infusion

scholarly journals AB1076 COLOR DOPPLER HIGH- FREQUENCY ULTRASOUND OF DIGITAL ARTERIES IN PATIENTS WITH SYSTEMIC SCLEROSIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1827.3-1827
Author(s):  
O. Alekseeva ◽  
N. Yudkina ◽  
A. Demina ◽  
A. Volkov ◽  
E. Nasonov
Keyword(s):  
Blood Flow ◽  
Systemic Sclerosis ◽  
Color Doppler ◽  
Laboratory Data ◽  
Clinical Signs ◽  
Vascular Complications ◽  
Nailfold Capillaroscopy ◽  
Exclusion Criterion ◽  
Digital Ulcers ◽  
Linear Probe

Background:Systemic sclerosis (SSc) can lead to vascular complications such as digital ulcers or pitting scars (DU/PS). These changes develop in most patients with SSc and exacerbate their condition. However, there are no methods for dynamic assessment of the vascular involvement. The dynamics of capillaroscopic changes is very slow.Objectives:The aim of the study was to compare blood flow parameters of digital arteries in SSc patients and healthy individuals and to compare with nailfold capillaroscopy and clinical signs of ischemia (DU/PS).Methods:32 SSc patients, mean age 49,5 [42,0; 59,0] yrs and 26 ‘healthy’, mean age 43,5 [33,0; 57,0], were included. Groups of patients differed by gender and age. The exclusion criterion was the presence of obliterating vascular disease of the upper extremities. An Esaote MyLab Twice US system with 22 MHz linear probe was used. A total of SSc patients and controls underwent Color Doppler ultrasonography (CDUS) of 376 (256 + 208) digital arteries to compare blood flow velocity, resistive indices (RIs) and presence of occlusion. Nailfold capillaroscopy, clinical and laboratory data were also evaluated.Results:In digital arteries, pulsatility index (PI), peak systolic velocity (PSV) and end-diastolic velocity (EDV) were significantly lower and RI higher in SSc patients compared with controls (PSV: 13,28 [9,88; 16,7] vs17,45 [12,65; 22,5] cm/s, p=0,008; EDV: 2,68 [1,78, 4,05] vs 6,37 [4,75; 8,5] cm/s, p=0,000; RI: 0,78 [0,69; 0,81] vs 0,68 [0,59; 0,74], p=0,005; PI: 1,73 [1,32; 2,19] vs 1,22 [0,99; 1,55], p=0,002).We did not find any correlation between two methods. Also, we did not reveal any correlation between DU/PS, clinical, laboratory data and CDUS, but we found relationship between DU/PS and avascular areas or capillaroscopic findings (r= 0,37, p=0,045 and r= 0,40, p=0,03 correspondingly).Conclusion:Blood flow is significantly decreased in digital arteries in SSc, but clinical features of vasculopathy depend on microcirculatory disorders. It is important to continue research to find methods for dynamic evaluation of microcirculatory changes.References:noDisclosure of Interests:None declared

The Effect of Caffeine on Digital Haemodynamics

1994 ◽  
Vol 19 (3) ◽  
pp. 301-302 ◽  
Author(s):  
B. BARTON ◽  
J. M. KLEINERT
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Room Temperature ◽  
Systolic Pressure ◽  
Middle Finger ◽  
Distal Phalanx ◽  
Normal Volunteers ◽  
Pulse Volume ◽  
Digital Pressure ◽  
Digital Blood Flow

Caffeine has been shown to increase mean blood pressure, but studies documenting the effect of caffeine on digits are lacking. We evaluated the effect of caffeine on digital blood pressure and pulse volume in normal volunteers. In the first part of the study, 24 subjects were given water containing either 200 mg of caffeine or placebo. Bilateral brachial and middle finger digital pressures were measured at room temperature before ingestion and at 30 and 60 minutes after ingestion. In the second part of the study, pulse volume recordings (PVRs) were obtained in 24 subjects at the level of the distal phalanx of the middle finger of one hand immediately prior to beverage ingestion and at 10 minute intervals for 90 minutes. Differences in mean digital systolic pressure, digital/brachial index, or PVR amplitude between the control and caffeine groups were not statistically significant. The administration of caffeine was found not to alter the haemodynamics of digital blood flow or digital pressure in this population.

Abstract 519: Therapeutic Angiogenesis by Peripheral Blood Mononuclear Cells and its Rationale for Designing a New Trial

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Kaoru Tateno ◽  
Yoshihide Fujimoto ◽  
Hiroshi Hasegawa ◽  
Toshio Nagai ◽  
Yoshio Kobayashi
Keyword(s):  
Blood Flow ◽  
Systemic Sclerosis ◽  
Therapeutic Angiogenesis ◽  
Arterial Blood Flow ◽  
Limb Amputation ◽  
Active Infection ◽  
Peripheral Blood Mononuclear ◽  
Anatomical Distribution ◽  
Arterial Blood ◽  
Selection Of

Background: Clinical trials of therapeutic angiogenesis that treat chronic critical limb ischemia (CLI) are revealing mixed results. This may partly be due to unapt patient selection or suboptimal study protocols. Here, from our registry, we report demographic and procedural characteristics of patients who underwent major limb amputation despite therapeutic angiogenesis. Methods: Registry of CLI patients who were treated by peripheral blood mononuclear cell (PBMNC) implantation was retrospectively analyzed. Cases that underwent major limb amputation within 6 months of the therapy were further investigated to clarify any features that might have affected their limb outcomes. Results and Discussions: Among total of 112 patients in the registry, eight cases lost to follow up and were excluded from this study. Sixteen patients (16/104, 15.4%) underwent major limb amputation within 6 months after therapeutic angiogenesis. Six amputees had active infection in the treated limb. Unlike excellent outcome by bone marrow derived cells, any patients with systemic sclerosis treated by PBMNC had poor limb salvage. However, half (8/16) of the amputees had experienced blood flow recovery, at least for transient period of two weeks. Among these patients, five limbs showed significant recovery of crural blood flow, while in the ipsilateral foot, distal blood flow deteriorated, indicating the flow steal phenomenon induced by cell therapy, which induces strong vasodilatation. Excluding patients with active infection or systemic sclerosis halved the limb amputation rate. Careful selection of sites to implant cells according to anatomical distribution of arterial blood flow could even have improved the limb salvage rate. Conclusion: When designing a clinical trial of therapeutic angiogenesis, (1) excluding patients with active infections, (2) proper treatment site considering anatomical distribution of arterial blood flow to avoid steal phenomenon, and (3) selection of cell source according to etiology of CLI, may clarify the efficacy of therapeutic angiogenesis.

scholarly journals Female sexual dysfunction in systemic sclerosis: The role of endothelial growth factor and endostatin

2018 ◽  
Vol 4 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Antonietta Gigante ◽  
Luca Navarini ◽  
Domenico Margiotta ◽  
Biagio Barbano ◽  
Antonella Afeltra ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Blood Flow ◽  
Systemic Sclerosis ◽  
Growth Factor ◽  
Sexual Dysfunction ◽  
Resistive Index ◽  
Serum Levels ◽  
Vascular Endothelial ◽  
Healthy Controls ◽  
Endothelial Growth Factor

Introduction: Since female sexual dysfunction in systemic sclerosis women is multifactorial, we can assume that vascular damage may play a role in pathogenesis. The aim of the study was to evaluate the clitoral blood flow, by Echo color Doppler, and to correlate it whit serum levels of vascular endothelial growth factor and endostatin. Methods: A total of 15 systemic sclerosis women and 10 healthy controls matched for sex and age were enrolled in this study. Serum VEGF165 and endostatin levels were determined in systemic sclerosis patients by commercial enzyme-linked immunosorbent assay kit. Clitoral blood flow was measured by Doppler indices of clitoral artery: pulsatile index, resistive index, and systolic/diastolic ratio were measured. Sexual dysfunction was assessed by Female Sexual Function Index. Results: Vascular endothelial growth factor (pg/mL) and endostatin (ng/mL) median values were significantly higher in systemic sclerosis women than healthy controls. Resistive index and systolic/diastolic ratio median values were significantly higher in systemic sclerosis women than healthy controls. Negative correlation exists between serum levels of vascular endothelial growth factor and resistive index (r = −0.55, p < 0.05). Positive correlation was observed between serum levels of endostatin and resistive index (r = 0.70, p < 0.01) and systolic/diastolic ratio (r = 0.77, p < 0.01). Discussion: We can suppose that clitoral blood flow in systemic sclerosis women is reduced not only for macro- and microvascular damage but also for impaired angiogenesis.

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