Human Microvascular Pericyte Basement Membrane Remodeling Regulates Neutrophil Recruitment

2015 ◽  
Vol 22 (1) ◽  
pp. 54-67 ◽  
Author(s):  
Parid Sava ◽  
Ian O. Cook ◽  
Rajwant S. Mahal ◽  
Anjelica L. Gonzalez
Keyword(s):  
Basement Membrane ◽  
Neutrophil Recruitment ◽  
Membrane Remodeling

scholarly journals MT1-MMP-mediated basement membrane remodeling modulates renal development

2010 ◽  
Vol 316 (17) ◽  
pp. 2993-3005 ◽  
Author(s):  
Karen S. Riggins ◽  
Glenda Mernaugh ◽  
Yan Su ◽  
Vito Quaranta ◽  
Naohiko Koshikawa ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Renal Development ◽  
Membrane Remodeling

Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension

2005 ◽  
Vol 232 (2) ◽  
pp. 268-281 ◽  
Author(s):  
Kimberly A. Moore ◽  
Tom Polte ◽  
Sui Huang ◽  
Bin Shi ◽  
Eben Alsberg ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Branching Morphogenesis ◽  
Membrane Remodeling ◽  
Embryonic Lung ◽  
Cytoskeletal Tension

scholarly journals Gelatinase B–deficient Mice Are Resistant to Experimental Bullous Pemphigoid

1998 ◽  
Vol 188 (3) ◽  
pp. 475-482 ◽  
Author(s):  
Zhi Liu ◽  
J. Michael Shipley ◽  
Thiennu H. Vu ◽  
Xiaoye Zhou ◽  
Luis A. Diaz ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Neutrophil Infiltration ◽  
Basement Membrane Zone ◽  
Neutrophil Recruitment ◽  
Gelatinase B ◽  
Collagen Xvii ◽  
Blistering Disease ◽  
Novel Therapeutic Strategies ◽  
Deficient Mice

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by deposition of autoantibodies at the basement membrane zone. In an experimental BP model in mice, the subepidermal blistering is mediated by antibodies directed against the hemidesmosomal protein BP180 (collagen XVII, BPAG2), and depends on complement activation and neutrophil infiltration. Gelatinase B is present in BP blister fluid and can cleave BP180. In this study we investigated the role of gelatinase B in the immunopathogenesis of experimental BP using mice containing targeted disruption of the gelatinase B (MMP-9, 92 kD gelatinase) gene. Gelatinase B–deficient mice were resistant to the blistering effect of intracutaneous anti-mBP180 antibodies, although these mice showed deposition of autoantibodies at the basement membrane zone and neutrophil recruitment to the skin comparable to that observed in the control mice. Interleukin 8 given intradermally concomitantly with pathogenic anti-mBP180 elicited a significant neutrophil recruitment into the skin in gelatinase B–deficient mice, but blistering did not occur. However, gelatinase B–deficient mice reconstituted with neutrophils from normal mice developed blistering in response to anti-mBP180 antibodies. These results implicate neutrophil-derived gelatinase B in the pathogenesis of experimental BP and might lead to novel therapeutic strategies for BP.

scholarly journals Granzyme B Promotes Cytotoxic Lymphocyte Transmigration via Basement Membrane Remodeling

Immunity ◽  
2014 ◽  
Vol 41 (6) ◽  
pp. 960-972 ◽  
Author(s):  
Monica D. Prakash ◽  
Marcia A. Munoz ◽  
Rohit Jain ◽  
Philip L. Tong ◽  
Aulikki Koskinen ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Granzyme B ◽  
Membrane Remodeling ◽  
Cytotoxic Lymphocyte

scholarly journals Tumor Necrosis Factor-α and IL-17A Activation Induces Pericyte-Mediated Basement Membrane Remodeling in Human Neutrophilic Dermatoses

2017 ◽  
Vol 187 (8) ◽  
pp. 1893-1906 ◽  
Author(s):  
Holly M. Lauridsen ◽  
Amanda S. Pellowe ◽  
Anand Ramanathan ◽  
Rebecca Liu ◽  
Kathryn Miller-Jensen ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Basement Membrane ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Membrane Remodeling ◽  
Neutrophilic Dermatoses ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion

2007 ◽  
Vol 104 (8) ◽  
pp. 2721-2726 ◽  
Author(s):  
A. Srivastava ◽  
J. C. Pastor-Pareja ◽  
T. Igaki ◽  
R. Pagliarini ◽  
T. Xu
Keyword(s):  
Basement Membrane ◽  
Tumor Invasion ◽  
Membrane Remodeling
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