Isolation, Purification, and Cultivation of Primary Retinal Microvascular Pericytes: A Novel Model Using Rats

2014 ◽  
Vol 21 (6) ◽  
pp. 478-489 ◽  
Author(s):  
Guanghui Liu ◽  
Chun Meng ◽  
Mingdong Pan ◽  
Meng Chen ◽  
Ruzhi Deng ◽  
...  
Keyword(s):  
Retinal Microvascular Pericytes ◽  
Novel Model

630: A Novel Model System for the Treatment of Renal Cancer by Nonmyeloablative Allogeneic Hemopoietic Cell Transplantation Using Cyclophosphamide in Mice

2005 ◽  
Vol 173 (4S) ◽  
pp. 172-172
Author(s):  
Masatoshi Eto ◽  
Masahiko Harano ◽  
Katsunori Tatsugami ◽  
Hirofumi Koga ◽  
Seiji Naito
Keyword(s):  
Cell Transplantation ◽  
Renal Cancer ◽  
Model System ◽  
Hemopoietic Cell ◽  
Novel Model

A Novel Model for Separate Estimates for Explicit and Implicit Memory

2012 ◽  
Author(s):  
Richard A. Chechile ◽  
Lara N. Sloboda ◽  
Erin L. Warren ◽  
Daniel H. Barch ◽  
Jessica R. Chamberland
Keyword(s):  
Implicit Memory ◽  
Novel Model

Metoclopramide Restores the Sympathoadrenal Response to Hypoglycemia in a Novel Model of HAAF

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 104-OR
Author(s):  
ADRIANA VIEIRA DE ABREU ◽  
RAHUL AGRAWAL ◽  
PARKER HOWE ◽  
SIMON J. FISHER
Keyword(s):  
Novel Model

A Possible Modulation Mechanism of Intramolecular and Intermolecular Interactions for NCAM Polysialylation and Cell Migration

2019 ◽  
Vol 19 (25) ◽  
pp. 2271-2282 ◽  
Author(s):  
Bo Lu ◽  
Xue-Hui Liu ◽  
Si-Ming Liao ◽  
Zhi-Long Lu ◽  
Dong Chen ◽  
...  
Keyword(s):  
Cell Migration ◽  
Intermolecular Interactions ◽  
Mammalian Cells ◽  
Molecular Mechanisms ◽  
Intramolecular Interaction ◽  
Polysialic Acid ◽  
Tumor Cell Migration ◽  
Neural Cell Adhesion ◽  
Polybasic Domains ◽  
Novel Model

Polysialic acid (polySia) is a novel glycan that posttranslationally modifies neural cell adhesion molecules (NCAMs) in mammalian cells. Up-regulation of polySia-NCAM expression or NCAM polysialylation is associated with tumor cell migration and progression in many metastatic cancers and neurocognition. It has been known that two highly homologous mammalian polysialyltransferases (polySTs), ST8Sia II (STX) and ST8Sia IV (PST), can catalyze polysialylation of NCAM, and two polybasic domains, polybasic region (PBR) and polysialyltransferase domain (PSTD) in polySTs play key roles in affecting polyST activity or NCAM polysialylation. However, the molecular mechanisms of NCAM polysialylation and cell migration are still not entirely clear. In this minireview, the recent research results about the intermolecular interactions between the PBR and NCAM, the PSTD and cytidine monophosphate-sialic acid (CMP-Sia), the PSTD and polySia, and as well as the intramolecular interaction between the PBR and the PSTD within the polyST, are summarized. Based on these cooperative interactions, we have built a novel model of NCAM polysialylation and cell migration mechanisms, which may be helpful to design and develop new polysialyltransferase inhibitors.

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