scholarly journals Stretch-Dependent Smooth Muscle Differentiation in the Portal Vein-Role of Actin Polymerization, Calcium Signaling, and microRNAs

2014 ◽  
Vol 21 (3) ◽  
pp. 230-238 ◽  
Author(s):  
Sebastian Albinsson ◽  
Anirban Bhattachariya ◽  
Per Hellstrand
Keyword(s):  
Smooth Muscle ◽  
Portal Vein ◽  
Calcium Signaling ◽  
Actin Polymerization ◽  
Muscle Differentiation ◽  
Smooth Muscle Differentiation

Embryonic mesenchymal cells share the potential for smooth muscle differentiation: myogenesis is controlled by the cell's shape

Development ◽  
1999 ◽  
Vol 126 (13) ◽  
pp. 3027-3033 ◽  
Author(s):  
Y. Yang ◽  
N.K. Relan ◽  
D.A. Przywara ◽  
L. Schuger
Keyword(s):  
Smooth Muscle ◽  
Mesenchymal Cell ◽  
Muscle Differentiation ◽  
Mesenchymal Cells ◽  
Membrane Potentials ◽  
Main Role ◽  
Visceral Muscle ◽  
Smooth Muscle Differentiation

Undifferentiated embryonic mesenchymal cells are round/cuboidal in shape. During development, visceral myogenesis is shortly preceded by mesenchymal cell elongation. To determine the role of the cell's shape on smooth muscle development, undifferentiated embryonic mesenchymal cells from intestine (abundant visceral muscle), lung (some visceral muscle) or kidney (no visceral muscle) were plated under conditions that maintained cell rounding or promoted elongation. Regardless of their fate in vivo, all the cells differentiated into smooth muscle upon elongation as indicated by the expression of smooth muscle-specific proteins and the development of membrane potentials of −60 mV and voltage-dependent Ca2+ currents, characteristic of excitable cells. Smooth muscle differentiation occurred within 24 hours and was independent of cell proliferation. Regardless of their fate in vivo, all the round cells remained negative for smooth muscle markers, had membrane potentials of −30 mV and showed no voltage-activated current. These cells, however, differentiated into smooth muscle upon elongation. The role of the cell's shape in controlling smooth muscle differentiation was not overcome by treatment with retinoic acid, TGF-beta1, PDGF BB or epithelial-conditioned medium (all modulators of smooth muscle differentiation). These studies suggest that the mesenchymal cell shape plays a main role in visceral myogenesis.

scholarly journals Smooth Muscle Differentiation Marker Gene Expression Is Regulated by RhoA-mediated Actin Polymerization

2000 ◽  
Vol 276 (1) ◽  
pp. 341-347 ◽  
Author(s):  
Christopher P. Mack ◽  
Avril V. Somlyo ◽  
Martina Hautmann ◽  
Andrew P. Somlyo ◽  
Gary K. Owens
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Actin Polymerization ◽  
Marker Gene ◽  
Muscle Differentiation ◽  
Marker Gene Expression ◽  
Smooth Muscle Differentiation ◽  
Differentiation Marker

scholarly journals Malignant Melanoma with Probable Smooth Muscle Differentiation

2014 ◽  
Vol 6 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Aya Morimoto ◽  
Jun Asai ◽  
Yusuke Wakabayashi ◽  
Satoshi Komori ◽  
Keiji Hanada ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Malignant Melanoma ◽  
Muscle Differentiation ◽  
Smooth Muscle Differentiation

scholarly journals Urothelium-derived Sonic hedgehog promotes mesenchymal proliferation and induces bladder smooth muscle differentiation

2010 ◽  
Vol 79 (4-5) ◽  
pp. 244-250 ◽  
Author(s):  
Mei Cao ◽  
Gregory Tasian ◽  
Ming-Hsien Wang ◽  
Benchun Liu ◽  
Gerald Cunha ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Sonic Hedgehog ◽  
Muscle Differentiation ◽  
Bladder Smooth Muscle ◽  
Smooth Muscle Differentiation
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