Host genetic factors associated with the range limit of a European hantavirus

2021 ◽  
Author(s):  
Moritz Saxenhofer ◽  
Anton Labutin ◽  
Thomas A. White ◽  
Gerald Heckel
Keyword(s):  
Genetic Factors ◽  
Range Limit ◽  
Factors Associated ◽  
Host Genetic ◽  
Host Genetic Factors

scholarly journals Host/genetic factors associated with COVID-19 call for precision medicine

2020 ◽  
Vol 3 (3) ◽  
pp. 228-234
Author(s):  
Alain R Thierry
Keyword(s):  
Precision Medicine ◽  
Genetic Factors ◽  
Inflammatory Responses ◽  
Risk Groups ◽  
Daily Basis ◽  
Severe Illness ◽  
Factors Associated ◽  
Clinical Complications ◽  
Host Genetic ◽  
Host Genetic Factors

Abstract If the current rate of infection are to be better managed, and future waves of infection kept at bay, it is absolutely necessary that the conditions and mechanisms of exposure to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) be better understood, as well as the downstream severe or lethal clinical complications. While the identification of notable comorbidities has now helped to define broad risk groups, the idiosyncratic responses of individual patients can generate unexpected clinical deterioration that is difficult to predict from initial clinical features. Thus, physicians caring for patients with COVID-19 face clinical dilemmas on a daily basis. The ability to decipher individual predispositions to SARS-CoV-2 infection or severe illness, in light of variations in host immunological and inflammatory responses, in particular as a result of genetic variations, would be of great benefit in infection management. To this end, this work associates the description of COVID-19 clinical complications, comorbidities, sequelae, and environmental and genetic factors. We also give examples of underlying genomic susceptibility to COVID-19, especially with regard to the newly reported link between the disease and the unbalanced formation of neutrophil extracellular traps. As a consequence, we propose that the host/genetic factors associated with COVID-19 call for precision medicine in its treatment. This is to our knowledge the first article describing elements towards precision medicine for patients with COVID-19.

scholarly journals Genome‐wide association study for host genetic factors associated with equine herpesvirus type‐1 induced myeloencephalopathy

2020 ◽  
Vol 52 (6) ◽  
pp. 794-798
Author(s):  
Wangisa M. B. Dunuwille ◽  
Navid YousefiMashouf ◽  
Udeni B. R. Balasuriya ◽  
Nicola Pusterla ◽  
Ernest Bailey
Keyword(s):  
Genetic Factors ◽  
Genome Wide Association Study ◽  
Equine Herpesvirus ◽  
Herpesvirus Type ◽  
Factors Associated ◽  
Genome Wide ◽  
Equine Herpesvirus Type 1 ◽  
Host Genetic ◽  
Host Genetic Factors

scholarly journals Host genetic factors associated to proviral load in Peruvian HTLV-1 infected

Retrovirology ◽  
2011 ◽  
Vol 8 (S1) ◽  
Author(s):  
Michael Talledo ◽  
Giovanni López ◽  
Jeroen R Huyghe ◽  
Kristien Verdonck ◽  
Elsa González ◽  
...  
Keyword(s):  
Proviral Load ◽  
Genetic Factors ◽  
Factors Associated ◽  
Host Genetic ◽  
Host Genetic Factors

scholarly journals Host Genetic Factors Associated with Symptomatic Primary HIV Infection and Disease Progression among Argentinean Seroconverters

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e113146 ◽  
Author(s):  
Romina Soledad Coloccini ◽  
Dario Dilernia ◽  
Yanina Ghiglione ◽  
Gabriela Turk ◽  
Natalia Laufer ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Disease Progression ◽  
Genetic Factors ◽  
Primary Hiv Infection ◽  
Factors Associated ◽  
Host Genetic ◽  
Host Genetic Factors

scholarly journals Vaginal microbiome Lactobacillus crispatus is heritable among European American women

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Michelle L. Wright ◽  
Jennifer M. Fettweis ◽  
Lindon J. Eaves ◽  
Judy L. Silberg ◽  
Michael C. Neale ◽  
...  
Keyword(s):  
Genetic Factors ◽  
European Ancestry ◽  
P Value ◽  
European American ◽  
Extrinsic Factors ◽  
American Women ◽  
Lactobacillus Crispatus ◽  
Host Genetic ◽  
Host Genetic Factors ◽  
European American Women

AbstractThe diversity and dominant bacterial taxa in the vagina are reported to be influenced by multiple intrinsic and extrinsic factors, including but not limited to pregnancy, contraceptive use, pathogenic states, socioeconomic status, and ancestry. However, the extent to which host genetic factors influence variation in the vaginal microbiota is unclear. We used a biometrical genetic approach to determine whether host genetic factors contribute to inter-individual differences in taxa from a sample of 332 twins who self-identified as being of African (44 pairs) or European ancestry (122 pairs). Lactobacillus crispatus, a major determinant of vaginal health, was identified as heritable among European American women (narrow-sense heritability = 34.7%, P-value = 0.018). Heritability of L. crispatus is consistent with the reduced prevalence of adverse reproductive disorders, including bacterial vaginosis and preterm birth, among women of European ancestry.

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