Quantitative trait loci for growth and body size in the nine-spined sticklebackPungitius pungitiusL.

2013 ◽  
Vol 22 (23) ◽  
pp. 5861-5876 ◽  
Author(s):  
Veronika N. Laine ◽  
Takahito Shikano ◽  
Gábor Herczeg ◽  
Johanna Vilkki ◽  
Juha Merilä
2021 ◽  
Author(s):  
L.‐y. Li ◽  
S.‐j. Xiao ◽  
J.‐m. Tu ◽  
Z.‐k. Zhang ◽  
H. Zheng ◽  
...  

2004 ◽  
Vol 20 (5) ◽  
pp. 748-757 ◽  
Author(s):  
Dean H Lang ◽  
Neil A Sharkey ◽  
Arimantas Lionikas ◽  
Holly A Mack ◽  
Lars Larsson ◽  
...  

2011 ◽  
Vol 42 (6) ◽  
pp. 670-674 ◽  
Author(s):  
Y. Gao ◽  
C. G. Feng ◽  
C. Song ◽  
Z. Q. Du ◽  
X. M. Deng ◽  
...  

2006 ◽  
Vol 17 (6) ◽  
pp. 526-537 ◽  
Author(s):  
Jane P. Kenney-Hunt ◽  
Ty T. Vaughn ◽  
L. Susan Pletscher ◽  
Andrea Peripato ◽  
Eric Routman ◽  
...  

1999 ◽  
Vol 74 (3) ◽  
pp. 313-322 ◽  
Author(s):  
TY T. VAUGHN ◽  
L. SUSAN PLETSCHER ◽  
ANDREA PERIPATO ◽  
KELLY KING-ELLISON ◽  
EMILY ADAMS ◽  
...  

Over 20 years ago, D. S. Falconer and others launched an important avenue of research into the quantitative of body size growth in mice. This study continues in that tradition by locating quantitative trait loci (QTLs) responsible for murine growth, such as age-specific weights and growth periods, and examining the genetic architecture for body weight. We identified a large number of potential QTLs in an earlier F2 intercross (Intercross I) of the SM/J and LG/J inbred mouse strains. Many of these QTLs are replicated in a second F2 intercross (Intercross II) between the same two strains. These replicated regions provide candidate regions for future fine-mapping studies. We also examined body size and growth QTLs using the combined data set from these two intercrosses, resulting in 96 microsatellite markers being scored for 1045 individuals. An examination of the genetic architecture for age-specific weight and growth periods resulted in locating 20 separate QTLs, which were mainly additive in nature, although dominance was found to affect early growth and body size. QTLs affecting early and late growth were generally distinct, mapping to separate chromosome locations. This QTL pattern indicates largely separate genetic and physiological systems for early and later murine growth, as Falconer suggested. We also found sex-specific QTLs for body size with implications for the evolution of sexual dimorphism.


BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Tetsumi Takahashi ◽  
Atsushi J. Nagano ◽  
Teiji Sota

Abstract Background Telmatochromis temporalis is a cichlid fish endemic to Lake Tanganyika. The normal and dwarf morphs of this fish are a clear example of ongoing ecological speciation, and body size plays an important role in this speciation event as a magic trait. However, the genetic basis underlying this trait has not been studied. Results Based on double-digested restriction-site associated DNA (ddRAD) sequencing of a hybrid cross between the morphs that includes F0 male, F0 female, and 206 F2 individuals, we obtained a linkage map consisting of 708 ddRAD markers in 22 linkage groups, which corresponded to the previously reported Oreochromis niloticus chromosomes, and identified one significant and five suggestive quantitative trait loci (QTL) for body size. From the body-size distribution pattern, the significant and three of the five suggestive QTL are possibly associated with genes responsible for the difference in body size between the morphs. Conclusions The QTL analysis presented here suggests that multiple genes, rather than a single gene, control morph-specific body size. The present results provide further insights about the genes underlying the morph specific body size and evolution of the magic trait during ecological speciation.


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