Denning, metabolic suppression, and the realisation of ecological opportunities in Ursidae

Mammal Review ◽  
2021 ◽  
Author(s):  
Nicholas L. Fowler ◽  
Thomas J. Spady ◽  
Guiming Wang ◽  
Bruce D. Leopold ◽  
Jerrold L. Belant
Keyword(s):  
Metabolic Suppression

scholarly journals The relationship between fasting-induced torpor, sleep and waking in laboratory mice

SLEEP ◽  
2021 ◽  
Author(s):  
Yi-Ge Huang ◽  
Sarah J Flaherty ◽  
Carina A Pothecary ◽  
Russell G Foster ◽  
Stuart N Peirson ◽  
...  
Keyword(s):  
Body Temperature ◽  
Rem Sleep ◽  
Brain Activity ◽  
Mammalian Species ◽  
Nrem Sleep ◽  
Laboratory Mice ◽  
State Classification ◽  
Metabolic Suppression ◽  
The Relationship ◽  
Electroencephalogram Eeg

Abstract Study objectives Torpor is a regulated and reversible state of metabolic suppression used by many mammalian species to conserve energy. Whereas the relationship between torpor and sleep has been well-studied in seasonal hibernators, less is known about the effects of fasting-induced torpor on states of vigilance and brain activity in laboratory mice. Methods Continuous monitoring of electroencephalogram (EEG), electromyogram (EMG) and surface body temperature was undertaken in adult, male C57BL/6 mice over consecutive days of scheduled restricted feeding. Results All animals showed bouts of hypothermia that became progressively deeper and longer as fasting progressed. EEG and EMG were markedly affected by hypothermia, although the typical electrophysiological signatures of NREM sleep, REM sleep and wakefulness enabled us to perform vigilance-state classification in all cases. Consistent with previous studies, hypothermic bouts were initiated from a state indistinguishable from NREM sleep, with EEG power decreasing gradually in parallel with decreasing surface body temperature. During deep hypothermia, REM sleep was largely abolished, and we observed shivering-associated intense bursts of muscle activity. Conclusions Our study highlights important similarities between EEG signatures of fasting-induced torpor in mice, daily torpor in Djungarian hamsters and hibernation in seasonally-hibernating species. Future studies are necessary to clarify the effects on fasting-induced torpor on subsequent sleep.

scholarly journals Cooling to Facilitate Metabolic Suppression in Healthy Individuals

2019 ◽  
Vol 90 (5) ◽  
pp. 475-479 ◽  
Author(s):  
Jon C. Rittenberger ◽  
Kathryn L. Flickinger ◽  
Alexandra Weissman ◽  
Melissa Repine ◽  
Jonathan Elmer ◽  
...  
Keyword(s):  
Healthy Individuals ◽  
Metabolic Suppression

Metabolic suppression in anoxic frog muscle

1998 ◽  
Vol 168 (4) ◽  
pp. 273-280 ◽  
Author(s):  
T. G. West ◽  
R. G. Boutilier
Keyword(s):  
Frog Muscle ◽  
Metabolic Suppression

scholarly journals Potential role for microRNA in regulating hypoxia-induced metabolic suppression in jumbo squids

2018 ◽  
Vol 1861 (6) ◽  
pp. 586-593 ◽  
Author(s):  
Hanane Hadj-Moussa ◽  
Samantha M. Logan ◽  
Brad A. Seibel ◽  
Kenneth B. Storey
Keyword(s):  
Potential Role ◽  
Metabolic Suppression

scholarly journals Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Beatris Mastelic-Gavillet ◽  
Blanca Navarro Rodrigo ◽  
Laure Décombaz ◽  
Haiping Wang ◽  
Giuseppe Ercolano ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Metabolic Suppression

Abstract LB-085: RG70099: A novel, highly potent dual IDO1/TDO inhibitor to reverse metabolic suppression of immune cells in the tumor micro-environment

2016 ◽  
Author(s):  
Gabor Gyulveszi ◽  
Christine Fischer ◽  
Massimiliano Mirolo ◽  
Martin Stern ◽  
Luke Green ◽  
...  
Keyword(s):  
Immune Cells ◽  
Metabolic Suppression
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