EP2 and EP3 receptors as therapeutic targets for underactive bladder/detrusor underactivity due to diabetic cystopathy in a type 1 diabetic rat model

2020 ◽  
Vol 12 (3) ◽  
pp. 285-291
Author(s):  
Noritoshi Sekido ◽  
Takeya Otsuki ◽  
Jun Kida ◽  
Hiroko Mashimo ◽  
Daisuke Wakamatsu ◽  
...  
Keyword(s):  
Rat Model ◽  
Therapeutic Targets ◽  
Diabetic Rat ◽  
Detrusor Underactivity ◽  
Underactive Bladder ◽  
Diabetic Cystopathy ◽  
Bladder Detrusor ◽  
Diabetic Rat Model

scholarly journals Nicotine Exposure Exacerbates Development of Cataracts in a Type 1 Diabetic Rat Model

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Nima Tirgan ◽  
Gabriela A. Kulp ◽  
Praveena Gupta ◽  
Adam Boretsky ◽  
Tomasz A. Wiraszka ◽  
...  
Keyword(s):  
Rat Model ◽  
Serum Levels ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Positive Trend ◽  
Sprague Dawley ◽  
Nicotine Treatment ◽  
Sprague Dawley Rats ◽  
Diabetic Rat Model

Diabetes and smoking are known risk factors for cataract development. In this study, we evaluated the effect of nicotine on the progression of cataracts in a type 1 diabetic rat model. Diabetes was induced in Sprague-Dawley rats by a single injection of 65 mg/kg streptozotocin. Daily nicotine injections were administered subcutaneously. Forty-five rats were divided into groups of diabetics with and without nicotine treatment and controls with and without nicotine treatment. Progression of lens opacity was monitored using a slit lamp biomicroscope and scores were assigned. To assess whether systemic inflammation played a role in mediating cataractogenesis, we studied serum levels of eotaxin, IL-6, and IL-4. The levels of the measured cytokines increased significantly in nicotine-treated and untreated diabetic animals versus controls and demonstrated a positive trend in the nicotine-treated diabetic rats. Our data suggest the presence of a synergistic relationship between nicotine and diabetes that accelerated cataract formation via inflammatory mediators.

scholarly journals Improved  -Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a  -Cell-Selective KATP Channel Opener

Diabetes ◽  
2004 ◽  
Vol 53 (4) ◽  
pp. 1089-1095 ◽  
Author(s):  
K. Skak ◽  
C. F. Gotfredsen ◽  
D. Lundsgaard ◽  
J. B. Hansen ◽  
J. Sturis ◽  
...  
Keyword(s):  
Cell Survival ◽  
Rat Model ◽  
Katp Channel ◽  
Diabetic Rat ◽  
Channel Opener ◽  
A Cell ◽  
Katp Channel Opener ◽  
Diabetic Rat Model

L-serine supplementation suppresses the formaiton of neurotoxic deoxysphingolipids and improves neuropathy in a type 1 diabetic rat model

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
T Hornemann ◽  
A Othman ◽  
A von Eckardstein ◽  
C Porretta-Serapiglia ◽  
G Lauria ◽  
...  
Keyword(s):  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model

scholarly journals Effects of endothelin antagonism on VEGF and NO levels in penile tissues in type 1 diabetic rat model

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Subrina Jesmin ◽  
Chishimba Mowa ◽  
Sohel Zaedi ◽  
Sayeeda Nusrat Sultana ◽  
Naoto Yamaguchi
Keyword(s):  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model

Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model

2017 ◽  
Vol 58 (3) ◽  
pp. 150-161 ◽  
Author(s):  
Paula Voabil ◽  
Joana Liberal ◽  
Ermelindo C. Leal ◽  
Jacques Bauer ◽  
José Cunha-Vaz ◽  
...  
Keyword(s):  
Rat Model ◽  
Nitrosative Stress ◽  
Diabetic Rat ◽  
Calcium Dobesilate ◽  
Diabetic Rat Model
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