Tadalafil Improves Symptoms, Erectile Function and Quality of Life in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (KYU-PRO Study)

2016 ◽  
Vol 10 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Ryosuke TAKAHASHI ◽  
Minoru MIYAZATO ◽  
Hisae NISHII ◽  
Yasuhiro SUMINO ◽  
Kazuo TAKAYAMA ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Benign Prostatic Hyperplasia ◽  
Lower Urinary Tract Symptoms ◽  
Erectile Function ◽  
Lower Urinary Tract ◽  
Prostatic Hyperplasia ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

Quality of life in patients with lower urinary tract symptoms after TURP for benign prostatic hyperplasia

Urologiia ◽  
2018 ◽  
Vol 1_2018 ◽  
pp. 53-61 ◽  
Author(s):  
D.Yu. Pushkar Pushkar ◽  
A.N. Bernikov Bernikov ◽  
L.A. Khodyreva Khodyreva ◽  
A.A. Dudareva Dudareva ◽  
S.Kh. Al'-Shukri Al'-Shukri ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Benign Prostatic Hyperplasia ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Prostatic Hyperplasia ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

scholarly journals HUBUNGAN ANTARA SKOR IPSS DENGAN QUALITY OF LIFE PADA PASIEN BPH DENGAN LUTS YANG BEROBAT DI POLI BEDAH RSUP PROF. DR. R. D. KANDOU MANADO

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Cristie S. Mandang ◽  
Richard A. Monoarfa ◽  
Billy Salem
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Benign Prostatic Hyperplasia ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Prostatic Hyperplasia ◽  
Cross Sectional ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

Abstract: Benign prostatic hyperplasia (BPH) is a disease that is rarely life-threatening, but resulting in annoying complaints and decreasing the quality of life of the patients. BPH is found in older men. BPH patients who come for treatment are usually accompanied with lower urinary tract symptoms (LUTS). BPH patients with LUTS symptoms usually come to the clinic when they feel that the symptoms are bothering their daily-lives, therefore, decreasing the quality of life (QoL). BPH is caused by many factors, as follows: knowledge, economic, social, or cultural factors. To determine the severity of BPH with LUTS, we used the International Prostate Symptom Scoring Score (IPSS) and 1 question about the quality of life. Based on the results of cross-sectional study in December 2014 we obtained 37 patients as samples. Most patients belonged to the age group of 70-79 years (62.2%). The majority of respondents had severe degree of IPSS score (20 patients, 54.1%). The value of QoL scores showed that 10 patients (27%) were not happy with their quality of life. The Spearman correlation test was used to find whether there was a correlation between the IPSS score and Quality of Life (QoL) of BPH patients with LUTS symptoms. There was a significant correlation (p < 0.005) between IPSS-QoL (r = 0.481). The reason that patients with symptoms of BPH LUTS came the surgical clinic of Prof. Dr R. D. Kandou Hospital Manado with severe symptoms and decreases QoL was their lack of knowledge about BPH.Keywords: BPH, LUTS, IPSS, QoL, ManadoAbstrak: Hiperplasia prostat jinak atau Benign Prostatic Hyperplasia (BPH) merupakan penyakit yangjarang mengancamjiwa tetapi cukup memberikan keluhan yang menjengkelkan dan menurunkan kualitas hidup penderitanya dan sering ditemukan pada pria usia lanjut. Pasien BPH yang datang berobat biasanya disertai dengan LUTS (lower urinary tract symptoms). Pasien BPH dengan gejala LUTS yang mencari pengobatan medis biasanya datang pada saat dirinya merasa bahwa gejala yang dirasakan sudah cukup menggangu aktivitas sehari-hari atau dengan kata lain, mengganggu kualitas hidupnya. Keadaan seperti ini disebabkan oleh banyak faktor, antara lain faktor pengetahuan, ekonomi, atau sosial budaya. Untuk menentukan derajat berat ringannya BPH yang disertai dengan gejala LUTS, digunakan skoring International Prostate Symptom Score (IPSS) dan 1 pertanyaan mengenai kualitas hidup. Berdasarkan hasil penelitian potong lintang yang dilakukan selama bulan Desember 2014 didapatkan 37 sampel. Insiden BPH terbanyak berada pada kisaran umur 70-79 tahun sebanyak 23 pasien (62,2%). Derajat BPH yang paling sering ialah derajat berat sebanyak 20 pasien (54,1%). Nilai skor kualitas hidup yang sering dirasakan pasien menunjukkan bahwa 10 pasien (27%) merasa tidak senang dengan kualitas hidupnya. Hasil uji korelasi antara IPSS-QOL didapatkan bermakna (p<0,005), dengan nilai r = 0,481. Faktor yang menjadi alasan mengapa pasien-pasien BPH dengan gejala LUTS yang berobat di Poli Bedah RSUP Prof. Dr. 490Mandang, Monoarfa, Salem: Hubungan antara skor...R. D. Kandou Manado datang dengan gejala yang berat dan kualitas hidup tidak senang ialah kurangnya pengetahuan mengenai BPH itu sendiri.Kata kunci: BPH, LUTS, IPSS, QOL, Manado

A pilot study of clinical results of Odyliresin (Iresine celosia) in symptomatic benign prostatic hyperplasia

2017 ◽  
Vol 10 (5) ◽  
pp. 464-470 ◽  
Author(s):  
D Porru ◽  
C Di Franco ◽  
V Bobbi ◽  
C Tinelli ◽  
B Rovereto
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Benign Prostatic Hyperplasia ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Prostatic Hyperplasia ◽  
Residual Volume ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

Aim: The aim of this pilot clinical trial was to determine if Odyliresin ( Iresine celosia), a cytochrome-flavoprotein with a powerful anti-oxidant action on cells, has a therapeutic effect on benign prostatic hyperplasia-related lower urinary tract symptoms, reducing symptoms and prostate volume, improving the patient’s quality of life and eventually limiting the number of patients who require surgery or endoscopy after medical treatment. Methods: Thirty patients with benign prostatic hyperplasia-related lower urinary tract symptoms were recruited and followed up. Primary outcomes were assessed using International Prostate Symptom Score symptom questionnaires, quality of life score, examination, prostate-specific antigen, transrectal ultrasound, uroflowmetry with post-void residual volume. Once recruited, patients were assigned for treatment: alpha-antagonist (alfuzosin 10 mg)+Odyliresin ( Iresine celosia) 2 ml, 20 drops once daily. Results: The results for quantitative variables were expressed as mean values and standard deviation as they were all normally distributed (Shapiro–Wilk test). The study included 30 patients with an average age of 68 years (range 56–80 years). The statistical analysis of data reports significant improvement of mean values of maximum urinary flow rate (+1.2, p=0.050), average flow rate (+0.47, p>0.002), International Prostate Symptom Score (–4.8, p=0.000), quality of life (–1.4, p=0.000), total prostatic volume (–1.7, p=0.000), prostatic adenoma (–6.9, p=0.000) and post-void residual volume (–17.8, p>0.004) between baseline and 12 months after treatment. No patient had acute urinary retention during treatment or need for benign prostatic hyperplasia-related surgery at the end of the 12-month treatment. Conclusions: All patients with benign prostatic hyperplasia-related lower urinary tract symptoms received both alphalitic and Odyliresin treatment. Clinical parameters and uroflowmetry parameters significantly improved, adenoma volume and post-void residual volume were significantly reduced at 12 months. This is the first clinical experience with Iresine celosia, a phytotherapeutic agent with no scientifically proven clinical efficacy so far in benign prostatic hyperplasia.

scholarly journals Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed, Isoflavonoids, and Cranberry Mix in Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Pilot Study

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Elie Nemr ◽  
Elie El Helou ◽  
Georges Mjaess ◽  
Albert Semaan ◽  
Josselin Abi Chebel
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Erectile Function ◽  
Lower Urinary Tract ◽  
Pumpkin Seed ◽  
Prostate Hyperplasia ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

Phytotherapy for lower urinary tract symptoms (LUTSs) due to benign prostate hyperplasia (BPH) is progressively demanded by patients and trusted by physicians. The aim was to assess the efficacy of a mix of pumpkin seed extract, soy germ isoflavonoids, and cranberry (Novex®) in the management of mild to moderate LUTS in BPH patients. Male patients aged ≥40 years, who had had mild to moderate LUTS for >6 months at screening, with no previous therapy or who are still symptomatic despite current use of alpha-blockers, were recruited. Exclusion criteria were an IPSS >19 and an age >80 years. The mixed compound was administered orally, daily, for 3 months. Patients were evaluated by means of IPSS, urological quality of life (uQoL) index, and International Index of Erectile Function (IIEF-5) at 3 visits: baseline (visit 1), 30 days (visit 2), and 90 days after treatment (visit 3). Among 163 screened patients, 128 patients (61.8 ± 9.9 years) were recruited. IPSS improved from 15 (Q1 : 12–Q3 : 17) in visit 1, to 11 (Q1 : 8–Q3 : 14) in visit 2, and to 9 (Q1 : 6–Q3 : 12) in visit 3 (p<0.001). uQoL improved from 4 (3–4) in visit 1, to 3 (2–3) in visit 2, and to 2 (1–2) in visit 3 (p<0.001). The patients had an IIEF-5 score of 15 (12–18.7) in visit 1, 15 (12–18) in visit 2, and 17 (13–19) in visit 3 (p=0.99 visits 1 vs. 2, p=0.004 visits 2 vs. 3, and p=0.001 visits 1 vs. 3). Treating mild to moderate LUTS/BPH patients with Novex® might therefore relieve symptoms, improve the quality of life, and have a mild beneficial effect on erectile function.

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