Sustained off therapy response after peglyated interferon favours functional cure and no disease progression in chronic hepatitis B

2020 ◽  
Author(s):  
Soon Kyu Lee ◽  
Jung Hyun Kwon ◽  
Sung Won Lee ◽  
Jeong Won Jang ◽  
Heechul Nam ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Disease Progression ◽  
Chronic Hepatitis B ◽  
Therapy Response ◽  
Functional Cure

scholarly journals Targeting Host Innate and Adaptive Immunity to Achieve the Functional Cure of Chronic Hepatitis B

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 216 ◽  
Author(s):  
Sayeh Ezzikouri ◽  
Mohammad Enamul Hoque Kayesh ◽  
Soumaya Benjelloun ◽  
Michinori Kohara ◽  
Kyoko Tsukiyama-Kohara
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Adaptive Immunity ◽  
Chronic Hepatitis B ◽  
Immune Modulation ◽  
Therapeutic Strategies ◽  
Functional Cure ◽  
Innate And Adaptive Immunity ◽  
Promising Target ◽  
Current Therapies

Despite the availability of an effective preventive vaccine for hepatitis B virus (HBV) for over 38 years, chronic HBV (CHB) infection remains a global health burden with around 257 million patients. The ideal treatment goal for CHB infection would be to achieve complete cure; however, current therapies such as peg-interferon and nucleos(t)ide analogs are unable to achieve the functional cure, the newly set target for HBV chronic infection. Considering the fact functional cure has been accepted as an endpoint in the treatment of chronic hepatitis B by scientific committee, the development of alternative therapeutic strategies is urgently needed to functionally cure CHB infection. A promising target for future therapeutic strategies is immune modulation to restore dysfunctional HBV-specific immunity. In this review, we provide an overview of the progress in alternative therapeutic strategies, including immune-based therapeutic approaches that enhance host innate and adaptive immunity to achieve and increase the functional cure from CHB infection.

scholarly journals Aiming for Functional Cure With Established and Novel Therapies for Chronic Hepatitis B

2021 ◽  
Author(s):  
Hannah S.J. Choi ◽  
Alexander Tonthat ◽  
Harry L.A. Janssen ◽  
Norah A. Terrault
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Novel Therapies ◽  
Functional Cure
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