scholarly journals Prognostic value of multiparametric magnetic resonance imaging, transient elastography and blood‐based fibrosis markers in patients with chronic liver disease

2020 ◽  
Vol 40 (12) ◽  
pp. 3071-3082 ◽  
Author(s):  
Arjun N. A. Jayaswal ◽  
Christina Levick ◽  
Emmanuel A. Selvaraj ◽  
Andrea Dennis ◽  
Jonathan C. Booth ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Liver Disease ◽  
Magnetic Resonance ◽  
Chronic Liver Disease ◽  
Prognostic Value ◽  
Transient Elastography ◽  
Chronic Liver ◽  
Resonance Imaging ◽  
Multiparametric Magnetic Resonance Imaging

scholarly journals Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease

2016 ◽  
Vol 64 (2) ◽  
pp. 308-315 ◽  
Author(s):  
Michael Pavlides ◽  
Rajarshi Banerjee ◽  
Joanne Sellwood ◽  
Catherine J. Kelly ◽  
Matthew D. Robson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Liver Disease ◽  
Magnetic Resonance ◽  
Chronic Liver Disease ◽  
Clinical Outcomes ◽  
Chronic Liver ◽  
Resonance Imaging ◽  
Multiparametric Magnetic Resonance Imaging

Double-Dose Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Patients With Chronic Liver Disease

2011 ◽  
Vol 46 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Utaroh Motosugi ◽  
Tomoaki Ichikawa ◽  
Katsuhiro Sano ◽  
Hironobu Sou ◽  
Kojiro Onohara ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Liver Disease ◽  
Magnetic Resonance ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Gadoxetic Acid ◽  
Double Dose ◽  
Resonance Imaging

Quantitative estimation of progression of chronic liver disease using gadoxetate disodium-enhanced magnetic resonance imaging

2018 ◽  
Vol 48 (9) ◽  
pp. 735-745 ◽  
Author(s):  
Akira Yamada ◽  
Yasunari Fujinaga ◽  
Takeshi Suzuki ◽  
Daisuke Komatsu ◽  
Yoshihiro Kitoh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Liver Disease ◽  
Magnetic Resonance ◽  
Chronic Liver Disease ◽  
Quantitative Estimation ◽  
Chronic Liver ◽  
Gadoxetate Disodium ◽  
Resonance Imaging

scholarly journals Blood Manganese Correlates with Brain Magnetic Resonance Imaging Changes in Patients with Liver Disease

1996 ◽  
Vol 23 (2) ◽  
pp. 95-98 ◽  
Author(s):  
Robert A. Hauser ◽  
Theresa A. Zesiewicz ◽  
Carlos Martinez ◽  
Alexander S. Rosemurgy ◽  
C.W. Olanow
Keyword(s):  
Magnetic Resonance Imaging ◽  
Liver Disease ◽  
Magnetic Resonance ◽  
Chronic Liver Disease ◽  
Brain Magnetic Resonance Imaging ◽  
Chronic Liver ◽  
Manganese Concentration ◽  
Resonance Imaging ◽  
Blood Manganese ◽  
Manganese Concentrations

ABSTRACT:Background: Chronic liver failure is associated with high signal abnormalities in the basal ganglia on Tl-weighted magnetic resonance imaging of the brain. These abnormalities are strikingly similar to those seen following manganese intoxication. As dietary manganese is normally cleared by the liver, we hypothesize that hepatic dysfunction could lead to manganese overload and account for the MR1 abnormalities seen in patients with chronic liver disease.Methods: We measured blood manganese concentrations in eleven patients with biopsy-proven hepatic cirrhosis and eleven healthy age and sex-matched controls. We also performed semi-quantitative measures of Tl signal abnormalities on MRI in the patients with chronic liver disease.Results: Patients with cirrhosis had significantly higher blood manganese concentrations (20.6 ± 10.2 mcg/L) than controls (7.2 ± 2.7, p = .0013). In addition, semi-quantitative scores of TI-weighted signal hyperintensity on MRI correlated with blood manganese concentration in patients with cirrhosis (r = .65, p = .029).Conclusions: These findings demonstrate that chronic liver disease is associated with manganese overload and suggest that manganese is responsible for the Tl-weighted signal hyperintensity seen on MRI of patients with liver disease. As manganese intoxication is known to cause parkinsonism and an encephalopathy similar to those which occur with chronic liver disease, it is possible that manganese toxicity contributes to the development of these symptoms in liver damaged patients and that therapies which prevent or reduce manganese overload may have clinical benefit.

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