scholarly journals Clinical utility of hepatocellular carcinoma risk scores in chronic hepatitis B

2020 ◽  
Vol 40 (3) ◽  
pp. 484-495 ◽  
Author(s):  
Thodoris Voulgaris ◽  
Margarita Papatheodoridi ◽  
Pietro Lampertico ◽  
George V. Papatheodoridis
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Clinical Utility ◽  
Risk Scores ◽  
Carcinoma Risk

scholarly journals Prediction models of long-term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles

Hepatology ◽  
2013 ◽  
Vol 58 (2) ◽  
pp. 546-554 ◽  
Author(s):  
Mei-Hsuan Lee ◽  
Hwai-I. Yang ◽  
Jessica Liu ◽  
Richard Batrla-Utermann ◽  
Chin-Lan Jen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Prediction Models ◽  
Risk Scores ◽  
Carcinoma Risk

Validation of hepatocellular carcinoma risk scores in Japanese chronic hepatitis B cohort receiving nucleot(s)ide analog

2020 ◽  
Vol 35 (9) ◽  
pp. 1595-1601 ◽  
Author(s):  
Sakura Kirino ◽  
Nobuharu Tamaki ◽  
Shun Kaneko ◽  
Masayuki Kurosaki ◽  
Kento Inada ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Risk Scores ◽  
Carcinoma Risk

Nomograms for Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B Virus Infection

2010 ◽  
Vol 28 (14) ◽  
pp. 2437-2444 ◽  
Author(s):  
Hwai-I Yang ◽  
Morris Sherman ◽  
Jun Su ◽  
Pei-Jer Chen ◽  
Yun-Fan Liaw ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Risk Scores ◽  
Chronic Hepatitis B Virus ◽  
B Virus ◽  
Model Derivation ◽  
Carcinoma Risk

Purpose Counseling patients with chronic hepatitis B virus (HBV) on their individual risk of liver disease progression is challenging. This study aimed to develop nomograms for predicting hepatocellular carcinoma risk in patients with chronic hepatitis B. Patients and Methods Two thirds of the Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer–Hepatitis B Virus (REVEAL-HBV) study cohort was allocated for model derivation (n = 2,435), and the remaining third was allocated for model validation (n = 1,218). Previously confirmed independent risk predictors included in three Cox proportional hazards regression models were sex, age, family history of hepatocellular carcinoma, alcohol consumption habit, serum ALT level, hepatitis B envelope antigen (HBeAg) serostatus, serum HBV DNA level, and HBV genotype. Regression coefficients were rounded into integer risk scores, and predicted risk over 5- and 10-year periods for each risk score was calculated and depicted in nomograms. The predictive accuracy was evaluated using the area under the receiver operating characteristic curve (AUROC) and the correlation between predicted and observed hepatocellular carcinoma risk. Results All selected risk predictors were statistically significant in all models. In each model, either HBeAg seropositivity or HBeAg seronegativity with high viral load (HBV DNA level ≥ 100,000 copies/mL) and genotype C infection had the highest risk scores. All AUROCs for risk prediction nomogram were ≥ 0.82 in both model derivation and validation sets. The correlation coefficients between the observed hepatocellular carcinoma risk and the nomogram-predicted risk were greater than 0.90 in all model derivation and validation sets. Conclusion These easy-to-use nomograms based on noninvasive clinical characteristics can accurately predict the risk of hepatocellular carcinoma in patients with chronic hepatitis B. They may facilitate risk communication between patients and clinicians.

scholarly journals Predictive performance of newer Asian hepatocellular carcinoma risk scores in treated Caucasians with chronic hepatitis B

JHEP Reports ◽  
2021 ◽  
pp. 100290
Author(s):  
George V. Papatheodoridis ◽  
George N. Dalekos ◽  
Ramazan Idilman ◽  
Vana Sypsa ◽  
Florian Van Boemmel ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Predictive Performance ◽  
Risk Scores ◽  
Carcinoma Risk

Assessing risk scores for predicting hepatocellular carcinoma in Thai patients with chronic hepatitis B

2021 ◽  
Author(s):  
Thanachote Kamalapirat ◽  
Kesinee Yingcharoen ◽  
Teerapat Ungtrakul ◽  
Kamonwan Soonklang ◽  
Jiraporn Dechma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Risk Scores
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