Acute liver failure caused by hepatitis E virus genotype 3 and 4: A systematic review and pooled analysis

2018 ◽  
Vol 38 (11) ◽  
pp. 1965-1973 ◽  
Author(s):  
Samir Haffar ◽  
Shalimar ◽  
Ravinder J. Kaur ◽  
Zhen Wang ◽  
Larry J. Prokop ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Pooled Analysis ◽  
Genotype 3 ◽  
Virus Genotype

Mo1475 - Acute Liver Failure Caused by Hepatitis E Virus Genotypes 3 and 4: A Systematic Review and Pooled Analysis

2018 ◽  
Vol 154 (6) ◽  
pp. S-726
Author(s):  
Fateh Bazerbachi ◽  
Samir Haffar ◽  
Shalimar ◽  
Ravinder Jeet Kaur ◽  
Larry Prokop ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Pooled Analysis ◽  
Virus Genotypes

scholarly journals Systematic review of the global epidemiology of viral-induced acute liver failure

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e037473
Author(s):  
Jenna Patterson ◽  
Hannah Sophia Hussey ◽  
Sheetal Silal ◽  
Liz Goddard ◽  
Mashiko Setshedi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hepatitis B ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
Parvovirus B19 ◽  
Hepatitis E ◽  
Virus Hepatitis ◽  
Global Epidemiology

ObjectivesThe aetiology and burden of viral-induced acute liver failure remains unclear globally. It is important to understand the epidemiology of viral-induced ALF to plan for clinical case management and case prevention.ParticipantsThis systematic review was conducted to synthesize data on the relative contribution of different viruses to the aetiology of viral-induced acute liver failure in an attempt to compile evidence that is currently missing in the field. EBSCOhost, PubMed, ScienceDirect, Scopus and Web of Science were searched for relevant literature published from 2009 to 2019. The initial search was run on 9 April 2019 and updated via PubMed on 30 September 2019 with no new eligible studies to include. Twenty-five eligible studies were included in the results of this review.ResultsThis systematic review estimated the burden of acute liver failure after infection with hepatitis B virus, hepatitis A virus, hepatitis C virus, hepatitis E virus, herpes simplex virus/human herpesvirus, cytomegalovirus, Epstein-Barr virus and parvovirus B19. Data were largely missing for acute liver failure after infection with varicella-zostervirus, human parainfluenza viruses, yellow fever virus, coxsackievirus and/or adenovirus. The prevalence of hepatitis A-induced acute liver failur was markedly lower in countries with routine hepatitis A immunisation versus no routine hepatitis A immunisation. Hepatitis E virus was the most common aetiological cause of viral-induced acute liver failure reported in this review. In addition, viral-induced acute liver failure had poor outcomes as indicated by high fatality rates, which appear to increase with poor economic status of the studied countries.ConclusionsImmunisation against hepatitis A and hepatitis B should be prioritised in low-income and middle-income countries to prevent high viral-induced acute liver failure mortality rates, especially in settings where resources for managing acute liver failure are lacking. The expanded use of hepatitis E immunisation should be explored as hepatitis E virus was the most common cause of acute liver failure.RegistrationPROSPERO registration number: CRD42017079730.

scholarly journals Liver transplantation for acute liver failure because of genotype 3 hepatitis E virus infection

2015 ◽  
Vol 21 (12) ◽  
pp. 1557-1559 ◽  
Author(s):  
Isobel Ramsay ◽  
Luke Snell ◽  
Vikram Sharma ◽  
James O'Beirne ◽  
David Patch ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Virus Infection ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3

Liver transplantation for acute liver failure related to autochthonous genotype 3 hepatitis E virus infection

2014 ◽  
Vol 38 (1) ◽  
pp. 24-31 ◽  
Author(s):  
Sarah Aherfi ◽  
Patrick Borentain ◽  
Ferdaous Raissouni ◽  
Aude Le Goffic ◽  
Michel Guisset ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Virus Infection ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3

scholarly journals Hepatitis E Virus Genotype 3 Strains in Domestic Pigs, Cameroon

2013 ◽  
Vol 19 (4) ◽  
pp. 686-688 ◽  
Author(s):  
Vanessa Salete de Paula ◽  
Matthias Wiele ◽  
Afegenwi H. Mbunkah ◽  
Achukwi M. Daniel ◽  
Manchang T. Kingsley ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Domestic Pigs

DETECTION AND PHYLOGENETIC CHARACTERIZATION OF HEPATITIS E VIRUS GENOTYPE 3 IN A CAPTIVE WILD BOAR IN THAILAND

2012 ◽  
Vol 43 (3) ◽  
pp. 640-644 ◽  
Author(s):  
Anuwat Wiratsudakul ◽  
Ladawan Sariya ◽  
Phirom Prompiram ◽  
Siriporn Tantawet ◽  
Duangkhamol Suraruangchai ◽  
...  
Keyword(s):  
Wild Boar ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Phylogenetic Characterization

scholarly journals No Evidence for Hepatitis E Virus Genotype 3 Susceptibility in Rats

2013 ◽  
Vol 19 (8) ◽  
pp. 1343-1345 ◽  
Author(s):  
Tian-Cheng Li ◽  
Yasushi Ami ◽  
Yuriko Suzaki ◽  
Naokazu Takeda ◽  
Wakita Takaji
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3 ◽  
Virus Genotype

scholarly journals Comprehensive Molecular Approach for Characterization of Hepatitis E Virus Genotype 3 Variants

2018 ◽  
Vol 56 (5) ◽  
Author(s):  
Bo Wang ◽  
Dominik Harms ◽  
C. Patrick Papp ◽  
Sandra Niendorf ◽  
Sonja Jacobsen ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis E Virus ◽  
Phylogenetic Analyses ◽  
Hepatitis E ◽  
Full Length ◽  
Molecular Approach ◽  
Genotype 3 ◽  
Genome Sequences ◽  
Virus Genotype ◽  
Pcr Targeting

ABSTRACT Autochthonous hepatitis E virus genotype 3 (HEV-3) infections in industrialized countries are more frequent than previously assumed. HEV-3 is zoonotic and the causal pathogen of chronic hepatitis E. According to the latest classification of the family Hepeviridae , 10 designated HEV-3 subtypes (HEV-3a to HEV-3j) and 7 unassigned HEV-3 subtypes are proposed. In order to identify and characterize the HEV-3 variants in circulation, we developed a molecular approach combining a sensitive HEV-specific real-time reverse transcription-PCR (RT-PCR) targeting the overlapping region of HEV ORF2 and ORF3 (the ORF2/3 region) and two newly designed consensus nested RT-PCRs targeting the HEV ORF1 and ORF2 genes, respectively. Since complete genome sequences are required for new HEV-3 subtype assignment, we implemented a straightforward approach for full-length HEV-3 genome amplification. Twenty-nine human serum samples and six human feces samples from chronic hepatitis E patients were selected for evaluation of the system. Viral loads ranged from 1 × 10 4 to 1.9 × 10 10 copies/ml of serum and from 1.8 × 10 4 to 1 × 10 12 copies/g of feces. Sequence and phylogenetic analyses of partial ORF1 and ORF2 sequences showed that HEV strains had considerable genetic diversity and clustered into the HEV-3c (29/35), HEV-3e (2/35), HEV-3f (2/35), and unassigned HEV-3 (2/35) subtypes. Moreover, from these strains, three full-length HEV-3 genome sequences were generated and characterized. DE/15-0030 represents a typical HEV-3c strain (95.7% nucleotide identity to wbGER27), while DE/15-0031 and SW/16-0282 have <89.2% homology to known HEV-3 strains and are phylogenetically divergent, indicating novel HEV-3 subtypes. In summary, our approach will significantly facilitate the detection, quantification, and determination of HEV-3 strains and will thus help to improve molecular diagnostics and our knowledge of HEV diversity and evolution.

scholarly journals Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3

2018 ◽  
Vol 38 (1) ◽  
pp. 65-70
Author(s):  
Alex J.S. de Souza ◽  
Andreza P. Malheiros ◽  
Manoel do C.P. Soares ◽  
Michele S. Gomes-Gouvêa ◽  
João R.R. Pinho ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Molecular Techniques ◽  
Human Consumption ◽  
Liver Lesions ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Liver Histopathology ◽  
Significant Difference ◽  
Group 2

ABSTRACT: Histopathological evaluation of liver from 33 pigs slaughtered for human consumption in Amazon region, previously tested by serology and molecular techniques for hepatitis E virus infection (HEV), was analysed in three groups: Group 1, negative for both HEV-RNA and anti-HEV IgG (n=10); Group 2, positive for HEV-RNA (n=13); Group 3, positive for anti-HEV IgG (n=10). Group 2 showed a significant difference among the groups for liver lesions such as lobular activity (P=0.007), periportal interface hepatitis (P=0.004), portal inflammation (P=0.028) hepatitis with lobular, portal and periportal interface activity (P=0.001). HEV detection by immunohistochemistry was performed and 3 of 6 samples of group 2 were positive. Pigs naturally infected by HEV genotype 3 present microscopic necroinflammatory liver lesions similar to HEV in humans. Liver histopathology showed be important in the diagnosis of active asymptomatic HEV infection in pigs slaughtered for human consumption because hepatic liver lesions may present distinct profiles according to molecular and serological diagnosis and in this sense, histopathology and immunohistochemistry may be an important complementary diagnostic tool.

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