Serum alanine aminotransferase level and liver-related mortality in patients with chronic hepatitis B: A large national cohort study

2018 ◽  
Vol 38 (10) ◽  
pp. 1751-1759 ◽  
Author(s):  
Jae-Jun Shim ◽  
Jung Wook Kim ◽  
Chi Hyuk Oh ◽  
Ye-Rin Lee ◽  
Ji Sung Lee ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Cohort Study ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Alanine Aminotransferase ◽  
Aminotransferase Level ◽  
Serum Alanine Aminotransferase ◽  
National Cohort ◽  
Alanine Aminotransferase Level ◽  
Related Mortality

Serum Alanine Aminotransferase and Hepatitis B DNA Flares in Pregnant and Postpartum Women with Chronic Hepatitis B

2016 ◽  
Vol 111 (10) ◽  
pp. 1410-1415 ◽  
Author(s):  
Christine Y Chang ◽  
Natali Aziz ◽  
Mugilan Poongkunran ◽  
Asad Javaid ◽  
Huy N Trinh ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Alanine Aminotransferase ◽  
Postpartum Women ◽  
Serum Alanine Aminotransferase

scholarly journals Transforming Growth Factor -β Level Might Be An Independent Factor Related to Occurrence of Chronic Hepatitis B

2021 ◽  
Author(s):  
Ming-hui Li ◽  
Yao Lu ◽  
Fang-fang Sun ◽  
Qi-qi Chen ◽  
Lu Zhang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Growth Factor ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Alanine Aminotransferase ◽  
Transforming Growth Factor ◽  
Independent Factor ◽  
Alanine Aminotransferase Level ◽  
Ifn Γ ◽  
Tgf Β1

Abstract To investigate association between immune cell-related cytokines and development of chronic hepatitis B (CHB). Patients with chronic hepatitis B virus (HBV) infection in immune tolerance (IT, n=30) and hepatitis B envelope antigen (HBeAg) positive CHB (n=250) were enrolled in the study. HBV virus, serological indicators, and plasma cytokine levels were detected at the time of enrollment. The results showed that there were significant differences in median age of patients (27 vs. 31y), alanine aminotransferase level (ALT, 29.85 vs 234.70 U/L), alanine aminotransferase level (AST, 23.40 vs. 114.90 U/L), HBsAg level (4.79 vs. 3.88 log10 IU/ml), HBeAg (1606.36 vs. 862.47 S/CO) and HBV DNA load (8.17 vs 6.71 log10 IU/ml) between IT and CHB groups (all P<0.01). The median values of Fms-like tyrosine kinase 3 ligand (FLT3-L), interferon-γ (IFN-γ), interleukin- 17A (IL-17A) and transforming growth factor- beta (TGF-β1) in IT group were significantly higher than those in CHB group (FLT3-L: 41.62 vs. 27.47 pg/ml; IFN-γ: 42.48 vs. 33.18 pg/ml; IL-17A: 15.66 vs. 8.90 pg/ml; TGF-β1: 4921.50 vs. 2234 pg/ml. All P<0.01). The median values of IFN-a2, TGF-β3 and IL-10 levels in IT group were significantly lower than those in CHB group (IFN-α2: 15.24 vs. 35.78 pg/ml, P=0.000; TGF-β3: 131.69 vs. 162.61 pg/ml, P=0.025; IL-10: 5.02 vs. 7.9 pg/ml, P=0.012). The multivariate logistic regression analysis indicated that TGF-β 1 (OR=0.999, 95% CI 0.999-1.000, P<0.001) and TGF-β2 levels (OR=1.008, 95%CI 1.004-1.012, P <0.001) were significantly associated with the incidence of CHB. The results suggest that TGF-β level might be an independent factor related to the occurrence of CHB.

Serum alanine aminotransferase level in relation to hepatitis B and C virus infections among blood donors

2008 ◽  
Vol 17 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Jung-Fa Tsai ◽  
Jen-Eing Jeng ◽  
Mei-Shang Ho ◽  
Ching-Shan Wang ◽  
Wen-Yu Chang ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Alanine Aminotransferase ◽  
Blood Donors ◽  
Aminotransferase Level ◽  
Virus Infections ◽  
Serum Alanine Aminotransferase ◽  
Alanine Aminotransferase Level
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