Metabolic alterations in a rat model of hepatic ischaemia reperfusion injury: In vivo hyperpolarized 13 C MRS and metabolic imaging

2018 ◽  
Vol 38 (6) ◽  
pp. 1117-1127 ◽  
Author(s):  
Chung-Man Moon ◽  
Sang-Soo Shin ◽  
Nam-Yeol Lim ◽  
Seul-Kee Kim ◽  
Yang-Joon Kang ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Model ◽  
Metabolic Imaging ◽  
Ischaemia Reperfusion Injury ◽  
Metabolic Alterations ◽  
Ischaemia Reperfusion

Gene Silencing using siRNA for Preventing Liver Ischaemia-Reperfusion Injury

2018 ◽  
Vol 24 (23) ◽  
pp. 2692-2700 ◽  
Author(s):  
H. Susana Marinho ◽  
Paulo Marcelino ◽  
Helena Soares ◽  
Maria Luísa Corvo
Keyword(s):  
Gene Silencing ◽  
Reperfusion Injury ◽  
Therapeutic Potential ◽  
Major Complication ◽  
Ischaemia Reperfusion Injury ◽  
Small Interference Rna ◽  
Ischaemia Reperfusion ◽  
Promising Therapeutic Approach ◽  
Sirna Therapy

Background: Ischaemia-reperfusion injury (IRI), a major complication occurring during organ transplantation, involves an initial ischemia insult, due to loss of blood supply, followed by an inflammation-mediated reperfusion injury. A variety of molecular targets and pathways involved in liver IRI have been identified. Gene silencing through RNA interference (RNAi) by means of small interference RNA (siRNA) targeting mediators of IRI is a promising therapeutic approach. Objective: This study aims at reviewing the use of siRNAs as therapeutic agents to prevent IRI during liver transplantation. Method: We review the crucial choice of siRNA targets and the advantages and problems of the use of siRNAs. Results: We propose possible targets for siRNA therapy during liver IRI. Moreover, we discuss how drug delivery systems, namely liposomes, may improve siRNA therapy by increasing siRNA stability in vivo and avoiding siRNA off-target effects. Conclusion: siRNA therapeutic potential to preclude liver IRI can be improved by a better knowledge of what molecules to target and by using more efficient delivery strategies.

Pretreatment with nebivolol attenuates level and expression of matrix metalloproteinases in a rat model of renal ischaemia-reperfusion injury

Nephrology ◽  
2017 ◽  
Vol 22 (12) ◽  
pp. 1023-1029 ◽  
Author(s):  
Sibel Ersan ◽  
Mehmet Tanrısev ◽  
Zahide Cavdar ◽  
Asli Celık ◽  
Mehtat Unlu ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischaemia Reperfusion Injury ◽  
Renal Ischaemia ◽  
Ischaemia Reperfusion

Sumatriptan protects against myocardial ischaemia–reperfusion injury by inhibition of inflammation in rat model

2019 ◽  
Vol 27 (5) ◽  
pp. 1071-1080 ◽  
Author(s):  
Mohammad Sheibani ◽  
Hedyeh Faghir-Ghanesefat ◽  
Saman Dehpour ◽  
Hedieh Keshavarz-Bahaghighat ◽  
Mohammad Reza Sepand ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Rat Model ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Mycophenolate mofetil attenuates uterine ischaemia/reperfusion injury in a rat model

2017 ◽  
Vol 34 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Gulcin Sahin Ersoy ◽  
Meryem Kurek Eken ◽  
Ozge Cevik ◽  
Ozlem T. Cilingir ◽  
Reshef Tal
Keyword(s):  
Mycophenolate Mofetil ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion
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