Serum microRNA profiles as diagnostic biomarkers for HBV-positive hepatocellular carcinoma

2017 ◽  
Vol 37 (6) ◽  
pp. 888-896 ◽  
Author(s):  
Hao-Tu Zhu ◽  
Rong-Bin Liu ◽  
Ya-Yong Liang ◽  
Abdulbaqi M. E. Hasan ◽  
Hai-Yun Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Biomarkers ◽  
Serum Microrna

scholarly journals Serum microRNA signatures and metabolomics have high diagnostic value in hepatocellular carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (65) ◽  
pp. 108810-108824 ◽  
Author(s):  
Hai-Ning Liu ◽  
Hao Wu ◽  
Yan-Jie Chen ◽  
Yu-Jen Tseng ◽  
Enkhnaran Bilegsaikhan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Value ◽  
Serum Microrna

Evaluation of Midkine and Golgi protein 73 as diagnostic biomarkers in hepatocellular carcinoma patients

2017 ◽  
Vol 30 (4) ◽  
pp. 1037
Author(s):  
EbtehalM Galbat ◽  
AmalF Makled ◽  
ShymaaA ElAskary ◽  
AmiraH ElKhyat ◽  
AsmaaI Gomaa
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Biomarkers ◽  
Golgi Protein

Identification of noninvasive diagnostic biomarkers for hepatocellular carcinoma by urinary proteomics

2020 ◽  
Vol 225 ◽  
pp. 103780 ◽  
Author(s):  
Yinghua Zhao ◽  
Yang Li ◽  
Wei Liu ◽  
Shan Xing ◽  
Dan Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Biomarkers ◽  
Urinary Proteomics

Serum microRNA expression profiling identifies serum biomarkers for HCV-related hepatocellular carcinoma

2019 ◽  
Vol 26 (4) ◽  
pp. 501-512 ◽  
Author(s):  
Jian Li ◽  
Boxun Jin ◽  
Tiezheng Wang ◽  
Wenlei Li ◽  
Zhenshun Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Expression Profiling ◽  
Serum Biomarkers ◽  
Microrna Expression ◽  
Serum Microrna

scholarly journals Serum microRNA expression profiling revealing potential diagnostic biomarkers for lung adenocarcinoma

2020 ◽  
Vol 133 (21) ◽  
pp. 2532-2542
Author(s):  
Xia Shan ◽  
Lan Zhang ◽  
Dan-Xia Zhu ◽  
Xin Zhou ◽  
Huo Zhang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Expression Profiling ◽  
Microrna Expression ◽  
Diagnostic Biomarkers ◽  
Serum Microrna

scholarly journals PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression

2019 ◽  
Vol 10 (11) ◽  
Author(s):  
Jianmin Sun ◽  
Yubao Zhang ◽  
Bing Li ◽  
Yuandi Dong ◽  
Chengming Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Treatment Strategies ◽  
Diagnostic Biomarkers ◽  
Cellular Processes ◽  
Candidate Mirnas ◽  
In Vivo Experiments ◽  
Wnt5a Expression ◽  
Hep3b Cells ◽  
Hcc Cells

Abstract LncRNA PITPNA-AS1 was a newly identified lncRNA which has never been studied in cancers. Whether PITPNA-AS1 participated in the development of hepatocellular carcinoma (HCC) is obscure. Given the coaction of lncRNAs and miRNAs to carcinogenesis, the purpose of the present research is to inquire how PITPNA-AS1 affects HCC progression. Firstly, PITPNA-AS1 was observed to be heightened in HCC tissues. Then function assays proved that overexpressing or silencing PITPNA-AS1 could manipulate the proliferation and motility of HCC cells. Besides, PITPNA-AS1 was located in the cytoplasm. Among the candidate miRNAs of PITPNA-AS1, miR-876-5p was an obvious target. Moreover, mechanism experiments validated that PITPNA-AS1 modulated WNT5A expression by targeting miR-876-5p. Rescue experiments affirmed that WNT5A silencing rescued the miR-876-5p suppression-induced cellular processes in PITPNA-AS1-silenced Hep3B cells. And in vivo experiments determined that PITPNA-AS1 regulated HCC progression in vivo via miR-876-5p/WNT5A pathway. In conclusion, this work shed lights on the modulatory mechanism of PITPNA-AS1/miR-876-5p/WNT5A axis in HCC, which might be pivotal for exploring effective diagnostic biomarkers and treatment strategies for HCC patients.

scholarly journals Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Hepatology ◽  
2019 ◽  
Vol 70 (2) ◽  
pp. 547-562 ◽  
Author(s):  
Jesus M. Banales ◽  
Mercedes Iñarrairaegui ◽  
Ander Arbelaiz ◽  
Piotr Milkiewicz ◽  
Jordi Muntané ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Diagnostic Biomarkers ◽  
Serum Metabolites
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