Direct antiviral agent treatment of chronic hepatitis C results in rapid regression of transient elastography and fibrosis markers fibrosis-4 score and aspartate aminotransferase-platelet ratio index

2016 ◽  
Vol 37 (3) ◽  
pp. 369-376 ◽  
Author(s):  
Jacqueline A. Bachofner ◽  
Piero V. Valli ◽  
Arne Kröger ◽  
Irina Bergamin ◽  
Patrizia Künzler ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Aspartate Aminotransferase ◽  
Transient Elastography ◽  
Antiviral Agent ◽  
Agent Treatment ◽  
Rapid Regression

scholarly journals Evaluation of aspartate aminotransferase to platelet ratio index and fibrosis 4 scores for hepatic fibrosis assessment compared with transient elastography in chronic hepatitis C patients

JGH Open ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 69-74
Author(s):  
Pimsiri Sripongpun ◽  
Pisit Tangkijvanich ◽  
Watcharasak Chotiyaputta ◽  
Phunchai Charatcharoenwitthaya ◽  
Roongruedee Chaiteerakij ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hepatic Fibrosis ◽  
Aspartate Aminotransferase ◽  
Transient Elastography ◽  
Chronic Hepatitis C Patients

Non-invasive fibrosis assessment in chronic hepatitis C: aspartate-aminotransferase to platelet ratio index (APRI) and transient elastography (FibroScan)

2010 ◽  
Vol 151 (47) ◽  
pp. 1951-1955 ◽  
Author(s):  
Alajos Pár ◽  
Gabriella Pár
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Aspartate Aminotransferase ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Non Invasive ◽  
Apri Score

Bár a májbiopszia ma is „arany standard” a hepatológiai diagnosztikában, újabban a nem invazív próbák is egyre inkább előtérbe kerülnek a májfibrosis értékelésében. A szerzők az aszpartát-aminotranszferáz/thombocyta hányados (APRI) és a májtömöttség (elaszticitás) vizsgálatán alapuló tranziens elasztográfia szerepét tanulmányozták krónikus hepatitis C-vírus- (HCV-) infekcióban.Betegek és módszerek:Száztizenkilenc HCV-fertőzött beteg közül 75 szenvedett biopsziával igazolt krónikus C-hepatitisben, 24 HCV-cirrhosisban, 20 egyén tünetmentes, tartósan normális alanin-aminotranszferáz enzim értéket mutató HCV-hordozó volt, és 30 egészséges véradó szerepelt kontrollként. AWaiszerinti APRI-score kiszámítása az aszpartát-aminotranszferáz- és a thrombocytaszám-értékek alapján, a fibrosisra utaló májtömöttség (liver stiffness, LS) vizsgálata ultrahangalapú tranziens elasztográfiával, FibroScan alkalmazásával, míg a METAVIR fibrosisscore megállapítása májbiopszia révén történt.Eredmények:Krónikus C-hepatitisben mindkét fibrosismarker értékei szignifikánsan magasabbak voltak, mint a kontrollcsoportban, legmagasabb HCV-cirrhosisban. A tünetmentes HCV-hordozók adatai alig tértek el az egészségesekétől. Mindkét mutató értékei korreláltak a hisztológiai stádiumokkal. Az LS-vizsgálat érzékenyebb volt a fibrosis diagnosztizálásában, mint az APRI. A két fibrosismarker adatain alapuló szekvenciális algoritmus szerint a krónikus C-hepatitises betegek 47,8%-ában a szignifikáns (F≥2) fibrosis biopszia nélkül is feltételezhető.Következtetés:Az APRI-score és a tranziens elasztográfia, különösen kombinációban, hasznos nem invazív eljárás a fibrosis értékelésében krónikus HCV-infekcióban. Orv. Hetil., 2010,47,1951–1955.

scholarly journals Factors Attenuating Zinc Deficiency Improvement in Direct-Acting Antiviral Agent-Treated Chronic Hepatitis C Virus Infection

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1620 ◽  
Author(s):  
Yi-Ling Ko ◽  
Daisuke Morihara ◽  
Kumiko Shibata ◽  
Ryo Yamauchi ◽  
Hiromi Fukuda ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Zinc Deficiency ◽  
Dietary Habits ◽  
Serum Zinc ◽  
Antiviral Agent ◽  
Zinc Status ◽  
Direct Acting Antiviral ◽  
Direct Acting

Zinc deficiency is frequently observed in chronic liver diseases. However, no studies have focused on the zinc status in chronic hepatitis C (HCV)-infected patients receiving direct-acting antiviral agents (DAAs). In this retrospective study, we assessed the serum zinc status in DAA-treated HCV patients with sustained virologic response for over two years (Zn-2y). Ninety-five patients were enrolled, whose baseline characteristics and blood parameters at DAA therapy initiation were collected. Baseline Zn < 65 µg/dL (odds ratio (OR) = 10.56, p < 0.001) and baseline uric acid (UA) > 5.5 mg/dL (OR = 9.99, p = 0.001) were independent risk factors for Zn-2y deficiency. A decision-tree algorithm classified low-baseline Zn and high-baseline UA as the first two variables, suggesting that baseline hypozincemia and hyperuricemia are prognosticators for long-term zinc deficiency. Baseline Zn was negatively correlated with the Fibrosis-4 (FIB-4) index, while baseline UA was significantly higher in habitual alcohol drinkers. In conclusion, serum zinc levels should be closely monitored, considering that zinc status improvement is related to liver fibrosis regression. Hyperuricemia indicates risks of developing metabolic disorders and subsequent zinc deficiency, for which an adjustment of personal lifestyle or dietary habits should be recommended clinically.

scholarly journals Comparison of FIB-4 and transient elastography in evaluating liver fibrosis of chronic hepatitis C subjects in community

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206947 ◽  
Author(s):  
Pin-Nan Cheng ◽  
Hung-Chih Chiu ◽  
Yen-Cheng Chiu ◽  
Shu-Chuan Chen ◽  
Yi Chen
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Transient Elastography

scholarly journals Liver stiffness in chronic hepatitis C virus infection

2019 ◽  
Vol 57 (2) ◽  
pp. 85-98
Author(s):  
Romeo-Gabriel Mihăilă
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Esophageal Varices ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Shear Wave Elastography ◽  
Stiffness Measurement ◽  
A Value

Abstract Introduction. The severity of liver fibrosis can be assessed noninvasively today by liver stiffness measurements. Vibration-controlled transient elastography, shear wave elastography or magnetic resonance elastography are techniques increasingly used for this purpose. Methods. This article presents the recent advances in the use of new techniques for liver fibrosis assessment in chronic hepatitis C: the correlation between liver stiffness values and liver fibrosis estimated by liver biopsies, the prognosis role of liver stiffness values, their usefulness in monitoring the treatment response, in assessing the severity of portal hypertension and in estimating the presence of esophageal varices. Scientific articles from January 2017 to January 2018 were searched in PubMed and PubMed Central databases, using the terms “liver stiffness” and “hepatitis C”. Results. The median liver stiffness values measured with different techniques are not identical, so that FibroScan thresholds cannot be used on any other elastographic machine. The higher the liver’s stiffness measurement, the higher the liver-related events in patients with chronic hepatitis C. A liver stiffness measurement over 17 kPa could be an independent predictor for the presence of esophageal varices as well as a spleen with a longitudinal span ≥ 15 cm for patients with a value of liver stiffness < 17 kPa. A progressive and persistent decrease in liver stiffness is dependent on sustained virological response achievement. The lack of liver stiffness decrease has been associated with relapsers and a low value of liver stiffness at baseline. Conclusion. Liver stiffness provides clues about the severity and evolution of liver disease.

scholarly journals Diagnostic accuracy of predictive indexes of liver fibrosis in patients with chronic hepatitis C

2020 ◽  
Vol 92 (2) ◽  
pp. 24-28
Author(s):  
I. V. Maev ◽  
E. I. Kuznetsova ◽  
D. N. Andreev ◽  
D. T. Dicheva
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Diagnostic Accuracy ◽  
Chronic Hepatitis C ◽  
Predictive Value ◽  
Transient Elastography ◽  
Reference Method ◽  
Cirrhosis Of The Liver ◽  
Severe Fibrosis

Aim.Assessment of the diagnostic accuracy of predictive indexes of liver fibrosis for the identification of severe fibrosis and cirrhosis (F3F4) in patients with chronic hepatitis C (CHC). Materials and methods.The retrospective design study included 127 patients with chronic hepatitis C (mean age 44.511.1 years). To assess the degree of liver fibrosis, all patients underwent transient elastography using a Fibroscan (EchoSens, France) and predictive indexes of liver fibrosis were calculated (APRI, FIB-4, discriminant Bonacini score). Transient elastography was considered as a reference method for assessing the degree of liver fibrosis for subsequent comparison of results with predictive fibrosis indixes. Results.The sensitivity of the APRI index for the identification of severe fibrosis and cirrhosis of the liver (F3F4) was 79%, and specificity was 69%. The FIB-4 index showed greater specificity (86%), but less sensitivity (68%). The sensitivity of the discriminant Bonacini scale was 81%, and the specificity was 77%. The positive predictive value of the APRI index, FIB-4 and the Bonacini scale for the identification of severe fibrosis and cirrhosis of the liver (F3F4) in patients with chronic hepatitis C was 66; 78 and 72% respectively, and negative predictive value 82; 78 and 84% respectively. Conclusion.The results of this study indicate the relatively high diagnostic accuracy of a number of predictive indexes for evaluating liver fibrosis (APRI, FIB-4, discriminant Bonachini scale) in identifying severe fibrosis and cirrhosis of the liver (F3F4) in patients with chronic hepatitis C.

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