scholarly journals Current challenges and future directions for liver transplantation

2016 ◽  
Vol 37 (3) ◽  
pp. 317-327 ◽  
Author(s):  
Pierluigi Toniutto ◽  
Alberto Zanetto ◽  
Alberto Ferrarese ◽  
Patrizia Burra
Keyword(s):  
Liver Transplantation ◽  
Future Directions

Antibody-mediated rejection in liver transplantation: Current controversies and future directions

2014 ◽  
Vol 20 (5) ◽  
pp. 514-527 ◽  
Author(s):  
Timucin Taner ◽  
Mark D. Stegall ◽  
Julie K. Heimbach
Keyword(s):  
Liver Transplantation ◽  
Future Directions ◽  
Antibody Mediated Rejection

scholarly journals New Breakthroughs for Liver Transplantation of Cholangiocarcinoma

2021 ◽  
Author(s):  
Robert R. McMillan ◽  
Ashish Saharia ◽  
Maen Abdelrahim ◽  
R. Mark Ghobrial
Keyword(s):  
Liver Transplantation ◽  
Randomized Trials ◽  
Retrospective Studies ◽  
Term Survival ◽  
Future Directions ◽  
Disease Biology ◽  
Improved Outcomes ◽  
Genetic Abnormalities ◽  
Established Role

Abstract Purpose Liver transplantation (LT) has gained ground as a treatment for cholangiocarcinoma. LT has achieved an established role as curative treatment for unresectable hilar cholangiocarcinoma (hCCA), and there are emerging data supporting its use in select patients with intrahepatic cholangiocarcinoma (iCCA). This review explores the current frontiers and future directions of LT for CCA. Recent Findings Results of retrospective studies support randomized trials of LT for resectable hCCA. Select patients with iCCA who have small tumors or favorable disease biology, as demonstrated by response to neoadjuvant therapy, have long-term survival after LT. Discoveries in the biology of iCCA show patients with FGFR and other genetic abnormalities have improved outcomes and may benefit from targeted therapies. Summary The outcomes of LT for CCA support its increased utilization. Policies should be considered to increase accessibility of donor organs for patients with iCCA.

scholarly journals Ex vivo machine perfusion: current applications and future directions in liver transplantation

2020 ◽  
Author(s):  
Julian Michelotto ◽  
Joseph M. G. V. Gassner ◽  
Simon Moosburner ◽  
Vanessa Muth ◽  
Madhukar S. Patel ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ex Vivo ◽  
Machine Perfusion ◽  
Donor Organ ◽  
Donor Pool ◽  
Future Directions ◽  
Link Type ◽  
Expanded Criteria ◽  
End Stage ◽  
Liver Machine Perfusion

Abstract Background Liver transplantation is the only curative treatment option for end-stage liver disease; however, its use remains limited due to a shortage of suitable organs. In recent years, ex vivo liver machine perfusion has been introduced to liver transplantation, as a means to expand the donor organ pool. Purpose To present a systematic review of prospective clinical studies on ex vivo liver machine perfusion, in order to assess current applications and highlight future directions. Methods A systematic literature search of both PubMed and ISI web of science databases as well as the ClinicalTrials.gov registry was performed. Results Twenty-one articles on prospective clinical trials on ex vivo liver machine perfusion were identified. Out of these, eight reported on hypothermic, eleven on normothermic, and two on sequential perfusion. These trials have demonstrated the safety and feasibility of ex vivo liver machine perfusion in both standard and expanded criteria donors. Currently, there are twelve studies enrolled in the clinicaltrials.gov registry, and these focus on use of ex vivo perfusion in extended criteria donors and declined organs. Conclusion Ex vivo liver machine perfusion seems to be a suitable strategy to expand the donor pool for liver transplantation and holds promise as a platform for reconditioning diseased organs.

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