Functional hepatocellular regeneration measured by hepatobiliary scintigraphy, functional regeneration or functional hepatocytes?

2015 ◽  
Vol 36 (3) ◽  
pp. 463-463
Author(s):  
Pim B. Olthof ◽  
Kasia P. Cieslak ◽  
Roelof J. Bennink ◽  
Thomas M. van Gulik
Keyword(s):  
Hepatobiliary Scintigraphy ◽  
Hepatocellular Regeneration ◽  
Functional Regeneration

Evidence for Impaired Hepatic Vitamin K1 Metabolism in Patients Treated with N-Methyl-Thiotetrazole Cephalosporins

1984 ◽  
Vol 51 (03) ◽  
pp. 358-361 ◽  
Author(s):  
H Bechtold ◽  
K Andrassy ◽  
E Jähnchen ◽  
J Koderisch ◽  
H Koderisch ◽  
...  
Keyword(s):  
Protein C ◽  
Oral Intake ◽  
Bleeding Complications ◽  
Side Chain ◽  
Acute Administration ◽  
Vitamin K1 ◽  
New Class ◽  
Parenteral Alimentation ◽  
Hepatocellular Regeneration ◽  
Echis Carinatus

SummaryIn 8 patients on no oral intake and with parenteral alimentation, administration of cephalosporins with N-methyl-thiotetrazole side chain (moxalactam, cefamandole), was associated with prolongation of prothrombin time, appearance in the circulation of descarboxy-prothrombin (counter immunoelectrophoresis and echis carinatus assay) and diminution of protein C. Acute administration of 10 mg vitamin Ki was followed by the transient appearance of vitamin K1 2,3-epoxide, indicating an impaired hepatocellular regeneration of vitamin K1 from the epoxide. Impaired hepatic vitamin K1 metabolism, tentatively ascribed to the N-methyl-thiotetrazole group, is one (but possibly not the only) cause of bleeding complications and depression of vitamin K1dependent procoagulants in patients treated with the new class of cephalosporins.

Enterogastric Reflux: an Uncommon Diagnosis Analyzed by Hepatobiliary Imaging

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Peter Wang
Keyword(s):  
Abdominal Pain ◽  
Digestive Enzymes ◽  
Gallbladder Disease ◽  
Hepatobiliary Scintigraphy ◽  
Hepatobiliary Imaging ◽  
Upper Gi ◽  
Gi Symptoms ◽  
Upper Abdominal ◽  
Enterogastric Reflux

Enterogastric reflux (EGR) is the reflux of bile and digestive enzymes from the small bowel into the stomach. While it is a normal physiologic process in small amounts, excessive reflux and chronic EGR can cause upper GI symptoms often mimicking more common diseases such as gallbladder disease and GERD that often leads to its underdiagnosis. Identifying EGR is significant as it has been associated with the development of gastroesophogeal pathology including gastritis, esophagitis, ulcers, and mucosal metaplasia. This article presents a 22-year-old male with enterogastric reflux causing upper abdominal pain and will discuss the role of hepatobiliary scintigraphy in its diagnosis.

scholarly journals Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yu Wang ◽  
Shanshan Jin ◽  
Dan Luo ◽  
Danqing He ◽  
Chunyan Shi ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Transcriptional Profiling ◽  
Collagen Scaffold ◽  
Defect Model ◽  
Tendon Regeneration ◽  
Biomimetic Scaffolds ◽  
Functional Regeneration

AbstractTendon injuries disrupt the balance between stability and mobility, causing compromised functions and disabilities. The regeneration of mature, functional tendons remains a clinical challenge. Here, we perform transcriptional profiling of tendon developmental processes to show that the extracellular matrix-associated protein periostin (Postn) contributes to the maintenance of tendon stem/progenitor cell (TSPC) functions and promotes tendon regeneration. We show that recombinant periostin (rPOSTN) promotes the proliferation and stemness of TSPCs, and maintains the tenogenic potentials of TSPCs in vitro. We also find that rPOSTN protects TSPCs against functional impairment during long-term passage in vitro. For in vivo tendon formation, we construct a biomimetic parallel-aligned collagen scaffold to facilitate TSPC tenogenesis. Using a rat full-cut Achilles tendon defect model, we demonstrate that scaffolds loaded with rPOSTN promote endogenous TSPC recruitment, tendon regeneration and repair with native-like hierarchically organized collagen fibers. Moreover, newly regenerated tendons show recovery of mechanical properties and locomotion functions.

A surgeon's view of hepatobiliary scintigraphy

1982 ◽  
Vol 12 (1) ◽  
pp. 2-4 ◽  
Author(s):  
Marvin L. Gliedman ◽  
Peter J. Wilk
Keyword(s):  
Hepatobiliary Scintigraphy

scholarly journals Assessment of Future Remnant Liver Function Using Hepatobiliary Scintigraphy in Patients Undergoing Major Liver Resection

2009 ◽  
Vol 14 (2) ◽  
pp. 369-378 ◽  
Author(s):  
Wilmar de Graaf ◽  
Krijn P. van Lienden ◽  
Sander Dinant ◽  
Joris J. T. H. Roelofs ◽  
Olivier R. C. Busch ◽  
...  
Keyword(s):  
Liver Resection ◽  
Liver Function ◽  
Hepatobiliary Scintigraphy ◽  
Remnant Liver ◽  
Future Remnant Liver ◽  
Major Liver Resection ◽  
Remnant Liver Function

Sprouting and functional regeneration of an identified serotonergic neuron following axotomy

1985 ◽  
Vol 16 (2) ◽  
pp. 137-151 ◽  
Author(s):  
A. Don Murphy ◽  
David L. Barker ◽  
Jeanne F. Loring ◽  
S. B. Kater
Keyword(s):  
Serotonergic Neuron ◽  
Functional Regeneration

Imaging-based evaluation of liver function: comparison of 99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI

2014 ◽  
Vol 25 (5) ◽  
pp. 1384-1391 ◽  
Author(s):  
Dominik Geisel ◽  
Lutz Lüdemann ◽  
Vera Fröling ◽  
Maciej Malinowski ◽  
Martin Stockmann ◽  
...  
Keyword(s):  
Liver Function ◽  
Hepatobiliary Scintigraphy ◽  
Enhanced Mri

scholarly journals Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Manon N. G. J. A. Braat ◽  
Hugo W. de Jong ◽  
Beatrijs A. Seinstra ◽  
Mike V. Scholten ◽  
Maurice A. A. J. van den Bosch ◽  
...  
Keyword(s):  
Treatment Planning ◽  
Hepatobiliary Scintigraphy
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